铁死亡与肥胖在子宫内膜癌发生发展中的关系

Relationship between Ferroptosis and Obesity in the Occurrence and Development of Endometrial Cancer

摘要: 子宫内膜癌是发生于子宫内膜的一种上皮性恶性肿瘤，是目前我国最常见的妇科恶性肿瘤。关于子宫内膜癌，现如今的主要治疗手段为手术及化疗，但对于晚期的内膜癌患者来说，现仍缺少良好的治疗方案以提高远期生存率。近年来，铁死亡的相关研究愈加火热，关于铁死亡与妇科恶性肿瘤的相关研究也越来越多，作为一种新型的非凋亡细胞死亡模式，现已证明，铁死亡在子宫内膜癌的发生、发展中起到重要作用，并且证明铁死亡与铁代谢、脂质代谢和氧化应激等生物过程密切相关，各项研究发现，在卵巢癌、子宫内膜癌和宫颈癌中存在脂质代谢异常，这些肿瘤细胞对铁死亡表现出很高的敏感性。通过调控肿瘤细胞的脂质代谢来诱导铁死亡，可能成为治疗妇科恶性肿瘤的新方向。

Abstract: Endometrial cancer is the sixth most common cancer in the world, and it is also the most common gynecological malignant tumor in China. For patients with advanced endometrial cancer, there is still a lack of good treatment to improve the long-term survival rate. In recent years, the research on ferroptosis has become more and more intense, and there are more and more related studies on ferroptosis and gynecological malignant tumor. It has been proved that ferroptosis plays an important role in the occurrence and development of endometrial cancer. As a programmed cell death mode, ferroptosis is closely related to biological processes, such as iron metabolism, lipid metabolism and oxidative stress. Abnormal metabolism of lipid substitutes is found in gynecological malignant tumors, such as ovarian cancer, endometrial cancer and cervical cancer, which shows high sensitivity to ferroptosis. Regulating lipid metabolism of tumor cells to induce ferroptosis is expected to be a new direction in the treatment of gynecological malignant tumors.

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^*通讯作者。