微卫星不稳定患者近亲属肠镜筛查的应用研究

Application of Colorectal Endoscopy Screening in Close Relatives of Patients with Microsatellite Instability

摘要: 目的：探讨肠镜检查在微卫星不稳定(MSI)患者近亲属结直肠病变中的应用价值。方法：筛选2022年1月至2025年3月临沂市肿瘤医院125例MSI患者近亲属，进行风险评估及肠镜检查，进一步分析结直肠病变的检出率及人群分布特征。结果：针对MSI患者近亲属进行科普宣传，(105/125)例接受肠镜检查，病变检出率为23.8% (25/105)，均为非进展期病变，男性及60岁以上人群检出率更高。结论：针对MSI患者近亲属的肠镜筛查，可有效辅助识别早期病变，需重点关注男性及高龄人群。

Abstract: Purpose: To explore the application value of colonoscopy in colorectal lesions of close relatives of microsatellite instability (MSI) patients. Methods: A total of 125 MSIs patients’ close relatives from Linyi Cancer Hospital were screened from January 2022 to March 2025, and risk assessment and colonoscopy were performed to further analyze the detection rate and population distribution characteristics of colorectal lesions. Results: Popular science publicity was carried out for close relatives of MSI patients. (105/125) underwent colonoscopy, and the detection rate of lesions was 23.8% (25/105), all of which were non-progressive lesions. The detection rate was higher in males and people over 60 years old. Conclusion: Colonoscopy screening for close relatives of MSI patients can effectively assist in the identification of early lesions, and should focus on men and elderly people.