独活寄生汤加减联合西药治疗肝肾亏虚证类风湿关节炎的临床观察

Clinical Observation on the Treatment of Rheumatoid Arthritis with Liver and Kidney Deficiency Syndrome by Modified Duhuo Jisheng Decoction Combined with Western Medicine

摘要: 目的：探讨独活寄生汤加减联合西药治疗肝肾亏虚证类风湿关节炎的临床疗效。方法：将60例肝肾亏虚证类风湿关节炎患者随机分为对照组、治疗组，每组30例。对照组给予西医对症治疗，治疗组在对照组的基础上加用独活寄生汤加减治疗，连续治疗8周。以中医证候评分，ESR、RF病情活动指标，TNF-α、IL-6、CRP血清炎症因子水平为评价指标。结果：两组的中医证候评分，ESR、RF病情活动指标，TNF-α、IL-6、CRP血清炎症因子指标均有所改善，治疗组优于对照组(P < 0.05)。结论：独活寄生汤加减联合西药治疗肝肾亏虚证类风湿关节炎效果明确，可进行临床推广。

Abstract: Objective: To explore the clinical efficacy of modified Duhuo Jisheng Decoction combined with Western medicine in the treatment of rheumatoid arthritis with liver and kidney deficiency syndrome. Methods: Sixty patients with rheumatoid arthritis and liver and kidney deficiency syndrome were randomly divided into a control group and a treatment group, with 30 patients in each group. The control group received conventional Western medicine treatment, while the treatment group received modified Duhuo Jisheng Decoction in addition to the treatment provided to the control group. The treatment lasted for 8 weeks. Evaluation indicators included Traditional Chinese Medicine (TCM) syndrome scores, disease activity indicators such as ESR and RF, and serum inflammatory factor levels including TNF-α, IL-6, and CRP. Results: Both groups showed improvements in TCM syndrome scores, disease activity indicators (ESR, RF), and serum inflammatory factor levels (TNF-α, IL-6, CRP). The treatment group exhibited better outcomes than the control group (P < 0.05). Conclusion: The combination of modified Duhuo Jisheng Decoction and Western medicine is effective in the treatment of rheumatoid arthritis with liver and kidney deficiency syndrome and can be clinically promoted.