基于代谢成像特征的预测模型构建：18F-FDG PET/CT在成人Still病相关合并巨噬细胞活化综合征中的研究

Construction of Prediction Model Based on Metabolic Imaging Features: A Study of 18F-FDG PET/CT in Adult-Onset Still’s Disease Complicated with Macrophage Activation Syndrome

摘要: 目的：探讨成人斯蒂尔病(AOSD)合并巨噬细胞活化综合征(MAS)的临床特点及预测模型。方法：选取2017年6月至2024年4月住院治疗的AOSD患者，收集临床资料并进行随访。结果：共纳入45例AOSD患者，将入选患者分为MAS组、和非MAS组，对两组临床症状、实验室指标及PET/CT参数进行比较，结果提示AOSD患者脾脏和骨髓的葡萄糖代谢与实验室炎症指标和全身评分相关、实验室指标联合PET/CT参数共同建立的预测模型对MAS具有更好的预测性能。

Abstract: Objective: To explore the clinical characteristics and prediction model of adult-onset Still’s disease (AOSD) complicated with macrophage activation syndrome (MAS). Methods: AOSD patients hospitalized from June 2017 to April 2024 were selected, and their clinical data were collected and followed up. Results: A total of 45 AOSD patients were included. The selected patients were divided into MAS group and non-MAS group. The clinical symptoms, laboratory indicators, and PET/CT parameters of the two groups were compared. The results indicated that the glucose metabolism of the spleen and bone marrow in AOSD patients was related to laboratory inflammatory indicators and systemic scores. The prediction model established by combining laboratory indicators with PET/CT parameters had better predictive performance for MAS.