循环炎症因子对坐骨神经损伤的影响
The Effect of Circulating Inflammatory Factors on Sciatic Nerve Injury
DOI: 10.12677/hjbm.2025.153054, PDF,   
作者: 贺文廷, 罗 丹:大理大学临床医学院,云南 大理;曲艳平:大庆油田总医院,黑龙江 大庆;范智东*:大理大学第一附属医院,云南 大理
关键词: 坐骨神经痛炎症因子腰椎间盘突出症糖尿病Sciatica Inflammatory Factors Lumbar Disc Herniation Diabetes
摘要: 坐骨神经痛是坐骨神经或脊髓在经受机械与炎症损伤之后产生的由坐骨神经支配范围疼痛的临床综合征,多表现为剧烈性疼痛和隐匿性疼痛。有时还可伴有其支配范围的无力与麻木异感,不积极的治疗甚至会转变为慢性疼痛,给患者带来极差的情感体验,严重影响患者的生活质量。随着医疗水平的提高和人民生活水平的提高,近几年对坐骨神经痛的研究日益加深,近些年来,炎性因子拮抗剂与受体阻断剂开始应用于临床治疗,本文对近年来坐骨神经痛与炎症因子在临床与实验室的研究进行综述。
Abstract: Sciatica is a clinical syndrome of pain innervated by the sciatic nerve after mechanical and inflammatory damage to the sciatic nerve or spinal cord, which is mostly manifested as severe pain and insidious pain. Sometimes it can be accompanied by weakness and numbness in the scope of its control, and inactive treatment can even turn into chronic pain, which brings extremely poor emotional experience to patients and seriously affects the quality of life of patients. With the improvement of medical standards and the quality of life of the people, research on sciatica has deepened in recent years. In recent years, antagonists of inflammatory factors and receptor blockers have begun to be applied in clinical treatment. This paper reviews the research on sciatica and inflammatory factors in clinical and laboratory settings in recent years.
文章引用:贺文廷, 罗丹, 曲艳平, 范智东. 循环炎症因子对坐骨神经损伤的影响[J]. 生物医学, 2025, 15(3): 465-472. https://doi.org/10.12677/hjbm.2025.153054

参考文献

[1] Akhaddar, A. (2023) Anatomy and Physiology of the Sciatic Nerve. In: Akhaddar, A., Ed., Atlas of Sciatica, Springer, 25-45. [Google Scholar] [CrossRef
[2] Konstantinou, K. and Dunn, K.M. (2008) Sciatica: Review of Epidemiological Studies and Prevalence Estimates. Spine, 33, 2464-2472. [Google Scholar] [CrossRef] [PubMed]
[3] Vialle, L.R., Vialle, E.N., Suárez Henao, J.E. and Giraldo, G. (2010) Lumbar Disc Herniation. Revista Brasileira de Ortopedia (English Edition), 45, 17-22. [Google Scholar] [CrossRef] [PubMed]
[4] Ropper, A.H. and Zafonte, R.D. (2015) Sciatica. New England Journal of Medicine, 372, 1240-1248. [Google Scholar] [CrossRef] [PubMed]
[5] Yadav, A. and Dabur, R. (2024) Skeletal Muscle Atrophy after Sciatic Nerve Damage: Mechanistic Insights. European Journal of Pharmacology, 970, Article ID: 176506. [Google Scholar] [CrossRef] [PubMed]
[6] Jiang, C., Li, Y., Guo, M., Li, X., Guo, J., Yu, S., et al. (2018) Acupotomy Therapy for Lumbar Disc Herniation: Protocol for a Systematic Review and Meta-Analysis. Medicine, 97, e12624. [Google Scholar] [CrossRef] [PubMed]
[7] Woolf, C.J. (2011) Central Sensitization: Implications for the Diagnosis and Treatment of Pain. Pain, 152, S2-S15. [Google Scholar] [CrossRef] [PubMed]
[8] Bostan, H. (2017) A Histopathological Examination: The Sciatic Nerve Injury Following Analgesic Drug Injection in Rats: A Histo-Pathological Examination. Northern Clinics of Istanbul, 5, 176-185. [Google Scholar] [CrossRef] [PubMed]
[9] Jungen, M.J., ter Meulen, B.C., van Osch, T., Weinstein, H.C. and Ostelo, R.W.J.G. (2019) Inflammatory Biomarkers in Patients with Sciatica: A Systematic Review. BMC Musculoskeletal Disorders, 20, Article No. 156. [Google Scholar] [CrossRef] [PubMed]
[10] Wu, Y., Lin, Y., Zhang, M., He, K. and Tian, G. (2024) Causal Association between Circulating Inflammatory Markers and Sciatica Development: A Mendelian Randomization Study. Frontiers in Neurology, 15, Article 1380719. [Google Scholar] [CrossRef] [PubMed]
[11] 陆征麟, 牛淑芳, 韩秋琼, 等. 黎医药熨疗法联合针刺治疗腰椎间盘突出型根性坐骨神经痛急性期患者的临床效果及对患者血清致疼因子和炎症因子水平的影响[J]. 广西医学, 2021, 43(20): 2425-2429.
[12] Zhang, D., Jing, B., Chen, Z., Li, X., Shi, H., Zheng, Y., et al. (2023) Ferulic Acid Alleviates Sciatica by Inhibiting Neuroinflammation and Promoting Nerve Repair via the TLR4/NF‐κB Pathway. CNS Neuroscience & Therapeutics, 29, 1000-1011. [Google Scholar] [CrossRef] [PubMed]
[13] Staszkiewicz, R., Gładysz, D., Gralewski, M., Garczarek, M., Gadzieliński, M. and Grabarek, B.O. (2023) Pathomechanism of the IVDs Degeneration and the Role of Neurotrophic Factors and Concentration of Selected Elements in Genesis of Low Back Pain. Current Pharmaceutical Biotechnology, 24, 1164-1177. [Google Scholar] [CrossRef] [PubMed]
[14] Cunha, C., Silva, A.J., Pereira, P., Vaz, R., Gonçalves, R.M. and Barbosa, M.A. (2018) The Inflammatory Response in the Regression of Lumbar Disc Herniation. Arthritis Research & Therapy, 20, Article No. 251. [Google Scholar] [CrossRef] [PubMed]
[15] Zhang, D., Chang, S., Li, X., Shi, H., Jing, B., Chen, Z., et al. (2022) Therapeutic Effect of Paeoniflorin on Chronic Constriction Injury of the Sciatic Nerve via the Inhibition of Schwann Cell Apoptosis. Phytotherapy Research, 36, 2572-2582. [Google Scholar] [CrossRef] [PubMed]
[16] Zhou, F.T., Zong, Y., Li, Y.B., et al. (2023) [Mechanism of Mongolian Drug Naru-3 in Initiation of Neuroinflammation of Neuropathic Pain from MMP9/IL-1β Signaling Pathway]. China Journal of Chinese Materia Medica, 48, 4173-4186.
[17] Zong, Y., Cao, R.L., Li, Y.B., et al. (2024) [Mongolian Medicine Naru-3 Reduces Neuroinflammation in Maintenance Stage of Neuropathic Pain by Inhibiting Astrocyte Activation]. China Journal of Chinese Materia Medica, 49, 2991-3001.
[18] Banala, R.R., Vemuri, S.K., EV, S., AV, G.R. and GPV, S. (2021) The Anti-Inflammatory and Cytoprotective Efficiency of Curvularin, a Fungal Macrolactone against Lipopolysaccharide-Induced Inflammatory Response in Nucleus Pulposus Cells: An in Vitro Study. Asian Spine Journal, 15, 143-154. [Google Scholar] [CrossRef] [PubMed]
[19] Hei, B., Ouyang, J., Zhou, J., Wang, D., Miao, Z. and Liu, R. (2022) Raddeanin a (RA) Reduced Acute Inflammatory Injury in Mouse Experimental Cerebral Hemorrhage by Suppression of TLR4. International Journal of Medical Sciences, 19, 1235-1240. [Google Scholar] [CrossRef] [PubMed]
[20] Wu, C., Wu, M., Lu, C., Tsai, H., Lu, Y. and Lin, C. (2021) Impact of Hepatoma-Derived Growth Factor Blockade on Resiniferatoxin-Induced Neuropathy. Neural Plasticity, 2021, Article ID: 8854461. [Google Scholar] [CrossRef] [PubMed]
[21] Qiao, X., Zhang, W. and Zhao, W. (2022) Role of CXCL10 in Spinal Cord Injury. International Journal of Medical Sciences, 19, 2058-2070. [Google Scholar] [CrossRef] [PubMed]
[22] Wu, Y., Xu, Y., Sun, J., Dai, K., Wang, Z. and Zhang, J. (2024) Inhibiting RIPK1-Driven Neuroinflammation and Neuronal Apoptosis Mitigates Brain Injury Following Experimental Subarachnoid Hemorrhage. Experimental Neurology, 374, Article ID: 114705. [Google Scholar] [CrossRef] [PubMed]
[23] Wu, Y., Pang, J., Peng, J., Cao, F., Guo, Z., Jiang, L., et al. (2019) Apolipoprotein E Deficiency Aggravates Neuronal Injury by Enhancing Neuroinflammation via the JNK/c-Jun Pathway in the Early Phase of Experimental Subarachnoid Hemorrhage in Mice. Oxidative Medicine and Cellular Longevity, 2019, Article ID: 3832648. [Google Scholar] [CrossRef] [PubMed]
[24] Tang, C., Hong, J., Hu, C., Huang, C., Gao, J., Huang, J., et al. (2021) Palmatine Protects against Cerebral Ischemia/Reperfusion Injury by Activation of the AMPK/Nrf2 Pathway. Oxidative Medicine and Cellular Longevity, 2021, Article ID: 6660193. [Google Scholar] [CrossRef] [PubMed]
[25] Nasir, A., Afridi, O.K., Ullah, S., Khan, H. and Bai, Q. (2024) Mitigation of Sciatica Injury-Induced Neuropathic Pain through Active Metabolites Derived from Medicinal Plants. Pharmacological Research, 200, Article ID: 107076. [Google Scholar] [CrossRef] [PubMed]
[26] Liu, Y., So, W., Qi Wong, N., Tan, H., Yu Lin, M., Yu Lee, I., et al. (2022) Diabetic Corneal Neuropathy as a Surrogate Marker for Diabetic Peripheral Neuropathy. Neural Regeneration Research, 17, 2172-2178. [Google Scholar] [CrossRef] [PubMed]
[27] Decroli, E., Manaf, A., Syahbuddin, S., Syafrita, Y. and Dillasamola, D. (2019) The Correlation between Malondialdehyde and Nerve Growth Factor Serum Level with Diabetic Peripheral Neuropathy Score. Open Access Macedonian Journal of Medical Sciences, 7, 103-106. [Google Scholar] [CrossRef] [PubMed]
[28] Wu, T., Su, G., Liu, T., Wang, H. and Hwu, C. (2023) Urinary Acrolein Protein Conjugates-to-Creatinine Ratio Is Positively Associated with Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus. Endocrine Connections, 12, e230253. [Google Scholar] [CrossRef] [PubMed]
[29] Zang, Y., Jiang, D., Zhuang, X. and Chen, S. (2023) Changes in the Central Nervous System in Diabetic Neuropathy. Heliyon, 9, e18368. [Google Scholar] [CrossRef] [PubMed]
[30] Afarideh, M., Zaker Esteghamati, V., Ganji, M., Heidari, B., Esteghamati, S., Lavasani, S., et al. (2019) Associations of Serum S100B and S100P with the Presence and Classification of Diabetic Peripheral Neuropathy in Adults with Type 2 Diabetes: A Case-Cohort Study. Canadian Journal of Diabetes, 43, 336-344.e2. [Google Scholar] [CrossRef] [PubMed]
[31] Fentie, D., Solomon, Y., Abebe, F., Derese, T., Tigstu, F. and Hailemariam, T. (2023) Diabetic Peripheral Neuropathy and Their Associations with Overweight/Obesity and Impaired Blood Glucose among Diabetic Patients in Eastern Ethiopia: Institutional-Based Study. SAGE Open Medicine, 11, 1-9. [Google Scholar] [CrossRef] [PubMed]
[32] Lv, Y., Yao, X., Li, X., Ouyang, Y., Fan, C. and Qian, Y. (2023) Cell Metabolism Pathways Involved in the Pathophysiological Changes of Diabetic Peripheral Neuropathy. Neural Regeneration Research, 19, 598-605. [Google Scholar] [CrossRef] [PubMed]
[33] Suryavanshi, U., Angadi, K.K., Reddy, V.S. and Reddy, G.B. (2024) Neuroprotective Role of Vitamin B12 in Streptozotocin-Induced Type 1 Diabetic Rats. Chemico-Biological Interactions, 387, Article ID: 110823. [Google Scholar] [CrossRef] [PubMed]
[34] 习雪峰. 运动和EGCG对Ⅱ型糖尿病大鼠海马线粒体功能的改善作用及机制研究[D]: [博士学位论文]. 苏州: 苏州大学, 2014.
[35] Aluko, E.O., David, U.E., Ojetola, A.A. and Fasanmade, A.A. (2024) The Antihypertensive Potential of Aqueous Extract of Peristrophe bivalvis (L.) Merr. Is via Up-Regulation of Cyclic Guanosine Monophosphate and Down-Regulation of the Renin-Angiotensin System. Cardiovascular & Hematological Disorders-Drug Targets, 24, 172-183. [Google Scholar] [CrossRef] [PubMed]
[36] Terashima, T., Katagi, M. and Ohashi, N. (2023) Neuronal-hematopoietic Cell Fusion in Diabetic Neuropathy. Stem Cells Translational Medicine, 12, 215-220. [Google Scholar] [CrossRef] [PubMed]
[37] Cosamalón-Gan, I., Cosamalón-Gan, T., Mattos-Piaggio, G., Villar-Suárez, V., García-Cosamalón, J. and Vega-Álvarez, J.A. (2021) Inflammation in the Intervertebral Disc Herniation. Neurocirugía (English Edition), 32, 21-35. [Google Scholar] [CrossRef
[38] Astur, N., Martins, D.E., Kanas, M., Doi, A.M., Martino, M.D.V., Filho, E.N.K., et al. (2024) Bacterial Identification in Herniated Intervertebral Discs: A Prospective Cohort Study. The Spine Journal, 24, 1910-1921. [Google Scholar] [CrossRef] [PubMed]
[39] Hinsen, K., Huynh, P., Shilling, M., Luo, H., Ehsanian, R. and Shin, P. (2024) Contrast Enhancing Epidural Fluid Accumulation after Percutaneous Endoscopic Lumbar Discectomy: A Case Report of Recurrent Disc Herniation within Pseudocyst Secondary to Irrigation Fluid. International Journal of Surgery Case Reports, 120, Article ID: 109884. [Google Scholar] [CrossRef] [PubMed]
[40] Di, Z., Zhenni, C., Zifeng, Z., Bei, J., Yong, C., Yixuan, L., et al. (2024) Danggui Sini Decoction Normalizes the Intestinal Microbiota and Serum Metabolite Levels to Treat Sciatica. Phytomedicine, 132, Article ID: 155740. [Google Scholar] [CrossRef] [PubMed]
[41] Zhang, J., Zhang, R., Wang, Y. and Dang, X. (2024) Efficacy of Epidural Steroid Injection in the Treatment of Sciatica Secondary to Lumbar Disc Herniation: A Systematic Review and Meta-Analysis. Frontiers in Neurology, 15, Article 1406504. [Google Scholar] [CrossRef] [PubMed]
[42] Zhu, Y., Zhang, Y., Gao, X., Li, L., Tang, Y. and Wang, Y. (2024) Protectin D1 Ameliorates Non-Compressive Lumbar Disc Herniation through SIRT1-Mediated CGRP Signaling. Molecular Pain, 20, 1-12. [Google Scholar] [CrossRef] [PubMed]
[43] Heider, F.C. and Siepe, C.J. (2024) Lumbaler Bandscheibenvorfall. Die Orthopädie, 54, 3-17. [Google Scholar] [CrossRef] [PubMed]
[44] Chen, S., Li, A., Feng, M., Zhong, W., Yang, L., Chen, X., et al. (2023) The Protective Effect of Wnt3a on Inflammatory Response in Oxygen-Glucose Deprivation/Reoxygenation (OGD/R) Astrocyte Model. Folia Neuropathologica, 61, 242-248. [Google Scholar] [CrossRef] [PubMed]
[45] Hao, L., Gao, M., Guo, W. and Yao, Z. (2024) Correlation between Risk Factors, Degree of Vascular Restenosis, and Inflammatory Factors after Interventional Treatment for Stroke: A Two-Center Retrospective Study. The Neurologist, 29, 233-237. [Google Scholar] [CrossRef] [PubMed]