脓毒症患儿抗生素的临床应用
Clinical Application of Antibiotics in Children with Sepsis
DOI: 10.12677/acm.2025.1551346, PDF,   
作者: 凌艳玉, 许 峰*：重庆医科大学附属儿童医院重症医学科，国家儿童健康与疾病临床研究中心，儿科发育疾病研究教育部重点实验室，儿童感染与免疫罕见病重庆市重点实验室，重庆
关键词: 脓毒症；儿童；抗生素；临床应用；Sepsis； Children； Antibiotics； Clinical Application
摘要: 脓毒症是一种高发病率和高死亡率的疾病，是儿童入住重症监护病房的主要原因之一，也是ICU患者死亡的主要原因。脓毒症极大危害了人类的健康，大大加重了社会的经济负担，消耗了大量的医疗资源，也给很多家庭带来了沉重的打击。脓毒症的救治面临着重大的挑战，及时有效的治疗方式干预有利于降低脓毒症的死亡率，改善患者远期预后，具有重大的意义。脓毒症由感染引起，抗生素是治疗脓毒症的重要措施，然而，抗生素的使用有一定的原则，过早使用抗生素或过多使用高级抗生素易造成超级耐药细菌的产生，过晚使用抗生素则不利于病人的救治，可能延误治疗，加重患者病情，增加死亡风险。抗生素规范合理的应用对脓毒症的救治至关重要，需引起临床工作者的高度重视，现对脓毒症患儿临床抗生素的应用情况做一综述，为优化临床脓毒症患儿的抗感染治疗方案提供一些参考。
Abstract: Sepsis is a disease with high morbidity and mortality. It is one of the main causes of intensive care unit admission in children and the leading cause of death in ICU patients. Sepsis greatly endangers human health, greatly increases the economic burden of society, consumes a lot of medical resources, and also brings a heavy blow to many families. The treatment of sepsis is facing major challenges. Timely and effective treatment intervention is of great significance to reduce the mortality rate of sepsis and improve the long-term prognosis of patients. Sepsis is caused by infection. Therefore, using antibiotics is an important measure for the treatment of sepsis. There are some principles for the use of antibiotics. Too early use of antibiotics or too many advanced antibiotics to be used can easily cause the emergence of drug-resistant bacteria, but too late use of antibiotics is not conducive to the treatment of patients, which may delay treatment, aggravate patients’ conditions, and increase the risk of death. The standardized and reasonable use of antibiotics is very important and requires great attention, especially for clinicians. The application of antibiotics in children with sepsis is reviewed to provide some references for optimizing the anti-infective treatment regimen for children with sepsis.
文章引用：凌艳玉, 许峰. 脓毒症患儿抗生素的临床应用[J]. 临床医学进展, 2025, 15(5): 93-99. https://doi.org/10.12677/acm.2025.1551346

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