抑郁和睡眠障碍与同型半胱氨酸的研究进展
Research Progress on Homocysteine Levels, Depression and Sleep Disorder
DOI: 10.12677/acm.2025.1551371, PDF,   
作者: 素比努力·阿斯木江:新疆医科大学研究生学院,新疆 乌鲁木齐;张 义*:新疆维吾尔自治区人民医院临床心理科,新疆 乌鲁木齐
关键词: 抑郁障碍睡眠障碍同型半胱氨酸高同型半胱氨酸Depression Sleep Disorder Homocysteine Hyperhomocysteinemia
摘要: 抑郁障碍(Depression disorder)是最常见的精神疾病,大部分患者都伴有睡眠问题。同时,长期的睡眠障碍(Sleep disorder)也能引起抑郁情绪,两者之间存在双向关系。同型半胱氨酸(Homocysteine, Hcy)是一种非必需含硫氨基酸,是多种疾病发生发展中的重要危险因素。目前有研究表明Hcy与抑郁障碍以及Hcy与睡眠障碍之间存在密切的联系。
Abstract: Depression is the most common mental disorder, and most patients have sleep problems. Meanwhile, long-term sleep disorders can also cause depressive emotions, and there is a bidirectional relationship between depression and sleep disorders. Homocysteine is a non essential sulfur-containing amino acid and an important risk factor in the occurrence and development of various diseases. Currently, studies have shown a close relationship between Homocysteine and depression, as well as between Hcy and sleep disorders.
文章引用:素比努力·阿斯木江, 张义. 抑郁和睡眠障碍与同型半胱氨酸的研究进展[J]. 临床医学进展, 2025, 15(5): 300-305. https://doi.org/10.12677/acm.2025.1551371

参考文献

[1] Lu, J., Xu, X., Huang, Y., Li, T., Ma, C., Xu, G., et al. (2021) Prevalence of Depressive Disorders and Treatment in China: A Cross-Sectional Epidemiological Study. The Lancet Psychiatry, 8, 981-990. [Google Scholar] [CrossRef] [PubMed]
[2] 秦聪聪, 金鑫, 王静, 等. 睡眠障碍与心血管疾病关系研究进展[J]. 心脏杂志, 2023, 35(1): 76-82.
[3] Wyse, A.T.S., Bobermin, L.D., dos Santos, T.M. and Quincozes-Santos, A. (2021) Homocysteine and Gliotoxicity. Neurotoxicity Research, 39, 966-974. [Google Scholar] [CrossRef] [PubMed]
[4] Sitdikova, G. and Hermann, A. (2023) Homocysteine: Biochemistry, Molecular Biology, and Role in Disease 2021. Biomolecules, 13, Article 1111. [Google Scholar] [CrossRef] [PubMed]
[5] Zeng, Y., Li, F., Yuan, S., Tang, H., Zhou, J., He, Q., et al. (2021) Prevalence of Hyperhomocysteinemia in China: An Updated Meta-Analysis. Biology, 10, Article 959. [Google Scholar] [CrossRef] [PubMed]
[6] Marroncini, G., Martinelli, S., Menchetti, S., Bombardiere, F. and Martelli, F.S. (2024) Hyperhomocysteinemia and Disease—Is 10 μmol/L a Suitable New Threshold Limit? International Journal of Molecular Sciences, 25, Article 12295. [Google Scholar] [CrossRef] [PubMed]
[7] Cordaro, M., Siracusa, R., Fusco, R., Cuzzocrea, S., Di Paola, R. and Impellizzeri, D. (2021) Involvements of Hyperhomocysteinemia in Neurological Disorders. Metabolites, 11, Article 37. [Google Scholar] [CrossRef] [PubMed]
[8] Xu, R., Huang, F., Wang, Y., Liu, Q., Lv, Y. and Zhang, Q. (2020) Gender-and Age-Related Differences in Homocysteine Concentration: A Cross-Sectional Study of the General Population of China. Scientific Reports, 10, Article No. 17401. [Google Scholar] [CrossRef] [PubMed]
[9] Fan, X., Zhang, L., Li, H., Chen, G., Qi, G., Ma, X., et al. (2020) Role of Homocysteine in the Development and Progression of Parkinson’s Disease. Annals of Clinical and Translational Neurology, 7, 2332-2338. [Google Scholar] [CrossRef] [PubMed]
[10] Akbari, A., Islampanah, M., Arhaminiya, H., Alvandi Fard, M.M., Jamialahmadi, T. and Sahebkar, A. (2024) Impact of Statin or Fibrate Therapy on Homocysteine Concentrations: A Systematic Review and Meta-Analysis. Current Medicinal Chemistry, 31, 1920-1940. [Google Scholar] [CrossRef] [PubMed]
[11] 孙可歆, 林凡琪, 王淑美, 等. 高同型半胱氨酸血症的研究现状及进展[J]. 吉林医药学院学报, 2025, 46(2): 135-139.
[12] Jung, S., Kim, Y., Choi, B. and Joo, N. (2021) Cut-off Value of Serum Homocysteine in Relation to Increase of Coronary Artery Calcification. Journal of Investigative Medicine, 69, 345-350. [Google Scholar] [CrossRef] [PubMed]
[13] Sharma, G.S., Kumar, T., Dar, T.A. and Singh, L.R. (2015) Protein N-Homocysteinylation: From Cellular Toxicity to Neurodegeneration. Biochimica et Biophysica Acta (BBA)—General Subjects, 1850, 2239-2245. [Google Scholar] [CrossRef] [PubMed]
[14] Ramakrishnan, S., Sulochana, K.N., Lakshmi, S., et al. (2006) Biochemistry of Homocysteine in Health and Diseases. Indian Journal of Biochemistry & Biophysics, 43, 275-283.
[15] Chung, K., Chiou, H. and Chen, Y. (2017) Associations between Serum Homocysteine Levels and Anxiety and Depression among Children and Adolescents in Taiwan Region. Scientific Reports, 7, Article No. 8330. [Google Scholar] [CrossRef] [PubMed]
[16] Kim, J., Stewart, R., Kim, S., Yang, S., Shin, I. and Yoon, J. (2008) Predictive Value of Folate, Vitamin B12 and Homocysteine Levels in Late-Life Depression. British Journal of Psychiatry, 192, 268-274. [Google Scholar] [CrossRef] [PubMed]
[17] Castro, F., Melgarejo, J., Chavez, C.A., de Erausquin, G.A., Terwilliger, J.D., Lee, J.H., et al. (2021) Total Plasma Homocysteine and Depressive Symptoms in Older Hispanics. Journal of Alzheimers Disease, 82, S263-S269. [Google Scholar] [CrossRef] [PubMed]
[18] Yu, J., Xue, R., Wang, Q., Yu, H. and Liu, X. (2022) The Effects of Plasma Homocysteine Level on the Risk of Three Major Psychiatric Disorders: A Mendelian Randomization Study. Frontiers in Psychiatry, 13, Article 841429. [Google Scholar] [CrossRef] [PubMed]
[19] Jain, R., Manning, S. and Cutler, A.J. (2019) Good, Better, Best: Clinical Scenarios for the Use of L-Methylfolate in Patients with MDD. CNS Spectrums, 25, 750-764. [Google Scholar] [CrossRef] [PubMed]
[20] Kwok, T., Wu, Y., Lee, J., Lee, R., Yung, C.Y., Choi, G., et al. (2020) A Randomized Placebo-Controlled Trial of Using B Vitamins to Prevent Cognitive Decline in Older Mild Cognitive Impairment Patients. Clinical Nutrition, 39, 2399-2405. [Google Scholar] [CrossRef] [PubMed]
[21] Collaboration, H.L.T. (1998) Lowering Blood Homocysteine with Folic Acid Based Supplements: Meta-Analysis of Randomised Trials. BMJ, 316, 894-898. [Google Scholar] [CrossRef
[22] He, J., Zhou, H., Xiong, J., Huang, Y., Huang, N. and Jiang, J. (2024) Association between Elevated Homocysteine Levels and Obstructive Sleep Apnea Hypopnea Syndrome: A Systematic Review and Updated Meta-Analysis. Frontiers in Endocrinology, 15, Article 1378293. [Google Scholar] [CrossRef] [PubMed]
[23] Chen, T., Winkelman, J.W., Mao, W., Yeh, C., Huang, S., Kao, T., et al. (2019) Short Sleep Duration Is Associated with Increased Serum Homocysteine: Insights from a National Survey. Journal of Clinical Sleep Medicine, 15, 139-148. [Google Scholar] [CrossRef] [PubMed]
[24] Mo, T., Wang, Y., Gao, H., Li, W., Zhou, L., Yuan, Y., et al. (2023) Sleep Duration, Midday Napping, and Serum Homocysteine Levels: A Gene-Environment Interaction Study. Nutrients, 15, Article 210. [Google Scholar] [CrossRef] [PubMed]
[25] 罗特丹, 周冲冲, 蒋科威, 等. 老年2型糖尿病患者睡眠障碍与同型半胱氨酸及糖化血红蛋白相关性研究[J]. 中国老年保健医学, 2021, 19(3): 37-39.
[26] 张红艳, 邓妙, 黄坚, 等. (围)绝经女性Hcy、CRP、脂质水平与睡眠质量的相关性分析[J]. 中国性科学, 2019, 28(12): 79-83.
[27] Tao, H., Chen, X., Zhou, H., Fu, J., Yu, Q. and Liu, Y. (2020) Changes of Serum Melatonin, Interleukin-6, Homocysteine, and Complement C3 and C4 Levels in Patients with Depression. Frontiers in Psychology, 11, Article 1271. [Google Scholar] [CrossRef] [PubMed]
[28] Kontoangelos, K., Papageorgiou, C.C., Raptis, A.E., Tsiotra, P., Lambadiari, V., Papadimitriou, G.N., et al. (2015) Homocysteine, Cortisol, Diabetes Mellitus, and Psychopathology. Journal of Diabetes Research, 2015, Article ID: 354923. [Google Scholar] [CrossRef] [PubMed]
[29] Maletic, V., Shelton, R. and Holmes, V. (2023) A Review of L-Methylfolate as Adjunctive Therapy in the Treatment of Major Depressive Disorder. The Primary Care Companion for CNS Disorders, 25, 22nr03361. [Google Scholar] [CrossRef] [PubMed]
[30] Bhatia, P. and Singh, N. (2015) Homocysteine Excess: Delineating the Possible Mechanism of Neurotoxicity and Depression. Fundamental & Clinical Pharmacology, 29, 522-528. [Google Scholar] [CrossRef] [PubMed]
[31] 王明慧, 董楠. 抑郁症患者血清同型半胱氨酸水平与抑郁症状和认知水平的相关性研究[J]. 微循环学杂志, 2023, 33(4): 80-83.
[32] Zhou, L. (2023) Homocysteine and Parkinson’s Disease. CNS Neuroscience & Therapeutics, 30, e14420. [Google Scholar] [CrossRef] [PubMed]
[33] Li, W., Yuan, W., Zhang, D., Cai, S., Luo, J. and Zeng, K. (2021) LCZ696 Possesses a Protective Effect against Homocysteine (HCY)-Induced Impairment of Blood-Brain Barrier (BBB) Integrity by Increasing Occludin, Mediated by the Inhibition of EGR-1. Neurotoxicity Research, 39, 1981-1990. [Google Scholar] [CrossRef] [PubMed]
[34] Bhattacharjee, N. and Borah, A. (2016) Oxidative Stress and Mitochondrial Dysfunction Are the Underlying Events of Dopaminergic Neurodegeneration in Homocysteine Rat Model of Parkinson’s Disease. Neurochemistry International, 101, 48-55. [Google Scholar] [CrossRef] [PubMed]