心房颤动与HP感染的相关性研究——Meta分析
Association between Atrial Fibrillation and Helicobacter pylori Infection—A Meta-Analysis
DOI: 10.12677/acm.2025.1551374, PDF,   
作者: 苏倚婷, 陈冬冬：暨南大学附属第一医院心血管内科，广东 广州
关键词: 心房颤动；幽门螺旋杆菌感染；Meta分析；Atrial Fibrillation； Helicobacter pylori Infection； Meta-Analysis
摘要: 目的：Meta分析系统评价心房颤动患者与幽门螺旋杆菌(HP)感染的相关性。方法：计算机检索中国知网(CNKI)、维普(VIP)、万方数据知识服务平台、PubMed、Embase、Cochrane等，检索时间限定为1999年1月~2024年1月，对纳入的病例对照研究进行数据提取及NOS量表评价，分析房颤患者与幽门螺旋杆菌感染是否存在相关性。结果：共检索到中英文文献177篇，12篇病例对照研究被纳入，3755例患者被纳入研究。纳入的12篇文献存在异质性(I2 = 66%, P = 0.0006)，因此选择随机效应模型合并效应量，得到OR = 1.66 (95%CI: 1.21~2.28, Z = 3.16, P = 0.002)，提示与非房颤组相比，房颤患者合并幽门螺旋杆菌感染的可能性更高。敏感性分析未考察出异质的来源。亚组分析提示亚洲、非洲地域的房颤患者合并HP感染可能性更高，而在欧美澳地区房颤与HP未见存在相关性。Begg检验提示发表偏倚较小。结论：在亚洲、非洲地区，HP感染会增加房颤的发生风险。
Abstract: Objective: This meta-analysis systematically evaluates the correlation between atrial fibrillation (AF) and Helicobacter pylori (HP) infection. Methods: Computerized searches were conducted in databases including CNKI, VIP, Wanfang, PubMed, Embase, and Cochrane, with the search period limited from January 1999 to January 2024. Data were extracted from included case-control studies, and the Newcastle-Ottawa Scale (NOS) was used for quality assessment. The analysis aimed to determine whether an association exists between AF and HP infection. Results: A total of 177 Chinese and English articles were retrieved, with 12 case-control studies (involving 3,755 patients) included in the final analysis. The included studies exhibited heterogeneity (I² = 66%, P = 0.0006), so a random-effects model was used to pool effect sizes. The combined odds ratio (OR) was 1.66 (95%CI: 1.21~2.28, Z = 3.16, P = 0.002), indicating that AF patients had a significantly higher likelihood of HP infection compared to non-AF controls. Sensitivity analysis did not identify the source of heterogeneity. Subgroup analysis suggested that AF patients in Asia and Africa had a higher probability of HP co-infection, whereas no significant correlation was found in Europe, America, or Australia. Begg’s test indicated minimal publication bias. Conclusion: In Asia and Africa, HP infection may increase the risk of atrial fibrillation.
文章引用：苏倚婷, 陈冬冬. 心房颤动与HP感染的相关性研究——Meta分析[J]. 临床医学进展, 2025, 15(5): 324-334. https://doi.org/10.12677/acm.2025.1551374

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