葡萄糖胺和鱼油与尿石症风险的关系：一项大型前瞻性队列研究

The Relationship between Glucosamine and Fish Oil and the Risk of Urolithiasis: A Large Prospective Cohort Study

摘要: 目的：探讨葡萄糖胺和鱼油与尿石症风险的关系，旨在为预防尿石症提供饮食指导。方法：通过英国生物银行从英国各地招募了约50万名年龄在40~69岁之间的参与者，通过下载国外公开数据库数据用于本研究。结果：葡萄糖胺使用者的尿石症风险显著降低(HR = 0.77, 95% CI: 0.72~0.83, P < 0.0001)。鱼油使用者在年龄调整和多变量调整模型中均表现出显著的尿石症风险降低(HR = 0.90, 95% CI: 0.84~0.95, P = 0.0006)。联合使用鱼油和葡萄糖胺的参与者表现出最强的保护效应。与非使用者相比，联合使用者的尿石症风险显著降低(HR = 0.83, 95% CI: 0.75~0.90, P < 0.0001)。结论：葡萄糖胺和鱼油联用能够降低尿石症发病风险。

Abstract: Objective: To investigate the association between glucosamine and fish oil with the risk of urolithiasis, and to provide dietary guidance for the prevention of urolithiasis. Methods: Approximately 500,000 participants aged 40~69 were recruited from across the United Kingdom through the UK Biobank, and data from publicly available international databases were downloaded for this study. Results: Glucosamine users exhibited a significantly reduced risk of urolithiasis (HR = 0.77, 95% CI: 0.72–0.83, P < 0.0001). Fish oil users also demonstrated a statistically significant reduction in urolithiasis risk in both age-adjusted and multivariable-adjusted models (HR = 0.90, 95% CI: 0.84~0.95, P = 0.0006). Participants who used both fish oil and glucosamine showed the strongest protective effect. Compared to non-users, the combined use of these supplements was associated with a significantly lower risk of urolithiasis (HR = 0.83, 95% CI: 0.75~0.90, P < 0.0001). Conclusion: The combined use of glucosamine and fish oil is associated with a reduced risk of urolithiasis.