儿童流感病毒感染的研究进展
Research Progress on Influenza Virus Infection in Children
DOI: 10.12677/acm.2025.1551440, PDF,   
作者: 单 娇, 尚晓丽*：昆明医科大学第二附属医院儿科，云南 昆明
关键词: 儿童；流感病毒；临床特征；治疗和预防；Child； Influenza Virus； Clinical Characteristics； Treatment and Prevention
摘要: 流行性感冒(流感)是由流感病毒引起的急性呼吸道传染病，具有传染性强及发病率高，起病急和易变异的特点。每年会引起不同严重程度的流行，大多数感染发生在儿童中，部分患儿可发展为严重病例，甚至因严重并发症而死亡，接种疫苗和及时抗病毒治疗可明显降低发病率和减少严重并发症。目前国内外研究在儿童流感方面取得较大进展，了解和掌握儿童流感的流行病学、临床特点及治疗和预防具有重要意义。
Abstract: Influenza is an acute respiratory infectious disease caused by influenza virus. It has high infectivity characteristics, high incidence, rapid onset, and easy of mutation. Every year, it will cause epidemics of different severity. Most infections occur in children. Some children can develop into serious cases and die from serious complications. Timely antiviral treatment and vaccination can effectively reduce the incidence rate and serious complications. At present, research at home and abroad has made great progress in children’s influenza. It is of great significance to understand and master the epidemiology, clinical characteristics, treatment and prevention of children’s influenza.
文章引用：单娇, 尚晓丽. 儿童流感病毒感染的研究进展[J]. 临床医学进展, 2025, 15(5): 825-830. https://doi.org/10.12677/acm.2025.1551440

参考文献

[1] Krammer, F., Smith, G.J.D., Fouchier, R.A.M., Peiris, M., Kedzierska, K., Doherty, P.C., et al. (2018) Influenza. Nature Reviews Disease Primers, 4, Article No. 3. [Google Scholar] [CrossRef] [PubMed]
[2] 流行性感冒诊疗方案(2020年版) [J]. 中国病毒病杂志, 2021, 11(1): 1-5.
[3] Peteranderl, C., Schmoldt, C. and Herold, S. (2016) Human Influenza Virus Infections. Seminars in Respiratory and Critical Care Medicine, 37, 487-500. [Google Scholar] [CrossRef] [PubMed]
[4] 戚春玲, 钟晓晴. 2022年广州地区儿童甲流早期白细胞的特点及临床意义[J]. 岭南急诊医学杂志, 2022, 27(6): 532-534.
[5] WHO (2021) Review of Global Influenza Circulation, Late 2019 to 2020, and the Impact of the COVID-19 Pandemic on Influenza Circulation.
https://www.who.int/publications/i/item/who-wer-9625-241-264
[6] Dharmapalan, D. (2020) Influenza. The Indian Journal of Pediatrics, 87, 828-832. [Google Scholar] [CrossRef] [PubMed]
[7] Kumari, R., Sharma, S.D., Kumar, A., Ende, Z., Mishina, M., Wang, Y., et al. (2023) Antiviral Approaches against Influenza Virus. Clinical Microbiology Reviews, 36, e0004022. [Google Scholar] [CrossRef] [PubMed]
[8] Li, J., Zhang, Y., Zhang, X. and Liu, L. (2022) Influenza and Universal Vaccine Research in China. Viruses, 15, Article 116. [Google Scholar] [CrossRef] [PubMed]
[9] Wolf, R.M. and Antoon, J.W. (2023) Influenza in Children and Adolescents: Epidemiology, Management, and Prevention. Pediatrics in Review, 44, 605-617. [Google Scholar] [CrossRef] [PubMed]
[10] Nypaver, C., Dehlinger, C. and Carter, C. (2021) Influenza and Influenza Vaccine: A Review. Journal of Midwifery & Women’s Health, 66, 45-53. [Google Scholar] [CrossRef] [PubMed]
[11] Otter, J.A., Donskey, C., Yezli, S., Douthwaite, S., Goldenberg, S.D. and Weber, D.J. (2016) Transmission of SARS and MERS Coronaviruses and Influenza Virus in Healthcare Settings: The Possible Role of Dry Surface Contamination. Journal of Hospital Infection, 92, 235-250. [Google Scholar] [CrossRef] [PubMed]
[12] 曾丽娥, 高培杰, 周文忠, 黄新垦. 儿童两种不同亚型甲流临床特征分析[J]. 右江医学, 2024, 52(8): 700-706.
[13] Shek, L.P. and Lee, B. (2003) Epidemiology and Seasonality of Respiratory Tract Virus Infections in the Tropics. Paediatric Respiratory Reviews, 4, 105-111. [Google Scholar] [CrossRef] [PubMed]
[14] Viboud, C., Alonso, W.J. and Simonsen, L. (2006) Influenza in Tropical Regions. PLOS Medicine, 3, e89. [Google Scholar] [CrossRef] [PubMed]
[15] Lowen, A.C., Mubareka, S., Steel, J. and Palese, P. (2007) Influenza Virus Transmission Is Dependent on Relative Humidity and Temperature. PLOS Pathogens, 3, e151. [Google Scholar] [CrossRef] [PubMed]
[16] Van Kerkhove, M.D., Vandemaele, K.A.H., Shinde, V., Jaramillo-Gutierrez, G., Koukounari, A., Donnelly, C.A., et al. (2011) Risk Factors for Severe Outcomes Following 2009 Influenza a (H1N1) Infection: A Global Pooled Analysis. PLOS Medicine, 8, e1001053. [Google Scholar] [CrossRef] [PubMed]
[17] 王凯萍, 李惠丽, 王艳. 不同亚型流感儿童住院病例临床特征分析[J]. 广州医药, 2019, 50(5): 90-93.
[18] 时玉霞, 周霖, 雷蕾, 刘伟娜, 徐通. 基于血常规的儿童甲型流行性感冒多参数预测模型[M]. 上海: 海军军医大学学报, 2024: 1371-1380.
[19] 赵琳琳, 文洪林, 李敏, 王凤至, 李梦, 冯晓朦, 田敬华. 2023-2024年北京某中医院0~14岁儿童流感病毒感染监测报告[J]. 中华医院感染学杂志, 2025(6): 914-917.
[20] 高蕊, 杨亚荣, 张晓芳. 儿童重症甲/乙型流感临床特点及免疫学特征比较[J]. 陕西医学杂志, 2022, 51(4): 458-461.
[21] Hoy, G., Kuan, G., López, R., Sánchez, N., López, B., Ojeda, S., et al. (2022) The Spectrum of Influenza in Children. Clinical Infectious Diseases, 76, e1012-e1020. [Google Scholar] [CrossRef] [PubMed]
[22] 陈洁, 张娜, 徐浩, 吕铁钢. 2020年6月-2023年4月临沂地区儿童流感流行病学及甲型流感临床特征[J]. 山东医药, 2023, 63(36): 73-77.
[23] Vabret, A., Dina, J., Cuvillon-Nimal, D., Nguyen, E., Gouarin, S., Petitjean, J., et al. (2010) La grippe saisonnière. Pathologie Biologie, 58, e51-e57. [Google Scholar] [CrossRef] [PubMed]
[24] Nicholson, K.G. (1992) Clinical Features of Influenza. Seminars in Respiratory Infections, 7, 26-37.
[25] Huang, W., Niu, W., Chen, H., Jiang, W., Fu, Y., Li, X., et al. (2023) Development of a Nomogram for Severe Influenza in Previously Healthy Children: A Retrospective Cohort Study. Journal of International Medical Research, 51, 1-6. [Google Scholar] [CrossRef] [PubMed]
[26] Kumar, V. (2016) Influenza in Children. The Indian Journal of Pediatrics, 84, 139-143. [Google Scholar] [CrossRef] [PubMed]
[27] Nayak, J., Hoy, G. and Gordon, A. (2019) Influenza in Children. Cold Spring Harbor Perspectives in Medicine, 11, a038430. [Google Scholar] [CrossRef] [PubMed]
[28] 田宝琳, 李守龙, 杨爱君. 流感病毒肺炎住院儿童的临床特征分析[J]. 中国医刊, 2023, 58(10): 1115-1121.
[29] Jia, C., Jia, W., Yi, X., Fu, S., Cui, Y., Li, P., et al. (2024) Clinical Analysis of Influenza in the Neonatal Intensive Care Unit. Italian Journal of Pediatrics, 50, Article No. 184. [Google Scholar] [CrossRef] [PubMed]
[30] 徐忠, 李莺, 华军, 吴水燕, 柏振江. 苏州地区儿童甲型和乙型流感临床特征比较[J]. 南京医科大学学报(自然科学版), 2017, 37(2): 224-226, 251.
[31] 郭文兴, 董鸿捌, 陆妹. 儿童重症甲型流行性感冒相关危险因素分析[J]. 中国妇幼保健, 2024, 39(23): 4697-4700.
[32] 韩阳. 2023年春某院甲型流感病毒感染儿童血常规分析[J]. 国际检验医学杂志, 2024, 45(8): 1018-1021.
[33] 王嘉馨, 郝东. COVID-19与甲型流感的临床特征及预后对比[J]. 中国现代医药杂志, 2024, 26(10): 107-110.
[34] Shirley, M. (2020) Baloxavir Marboxil: A Review in Acute Uncomplicated Influenza. Drugs, 80, 1109-1118. [Google Scholar] [CrossRef] [PubMed]
[35] Świerczyńska, M., Mirowska-Guzel, D.M. and Pindelska, E. (2022) Antiviral Drugs in Influenza. International Journal of Environmental Research and Public Health, 19, Article 3018. [Google Scholar] [CrossRef] [PubMed]
[36] You, H., Huang, C., Chen, C., Chang, C., Liao, P. and Huang, S. (2018) Anti-pandemic Influenza a (H1N1) Virus Potential of Catechin and Gallic Acid. Journal of the Chinese Medical Association, 81, 458-468. [Google Scholar] [CrossRef] [PubMed]
[37] Price, A.M., Flannery, B., Talbot, H.K., Grijalva, C.G., Wernli, K.J., Phillips, C.H., et al. (2022) Influenza Vaccine Effectiveness against Influenza A(H3N2)-Related Illness in the United States during the 2021-2022 Influenza Season. Clinical Infectious Diseases, 76, 1358-1363. [Google Scholar] [CrossRef] [PubMed]
[38] 袁华, 林兰芬, 王芳. 儿童接种流感疫苗对流行性感冒的预防效果[J]. 中国城乡企业卫生, 2023, 38(8): 71-73.
[39] 程诗洋, 刘庆伟, 李士坡, 马兴元. 预防甲型流感的新型及通用疫苗研发新进展[J]. 中国生物工程杂志, 2024, 44(11): 54-65.

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