严重烧伤免疫炎性反应和乌司他丁治疗的研究进展

Research Progress on Immune Inflammatory Response in Severe Burn and the Treatment with Ulinastatin

摘要: 当严重烧伤等强烈或持久的刺激作用于机体时，机体的调控能力不足，会引发过度应激和炎症失控。这导致免疫系统受到损害，许多参与调控的免疫细胞和免疫分子出现异常表达或功能失常，最终表现为免疫紊乱。乌司他丁是一种内源性的广谱蛋白酶抑制剂，具有抑制多种蛋白酶、稳定细胞膜系统、改善微循环以及调节免疫等作用。其非特异性的抗炎作用使其在烧伤、全身炎症反应综合征等临床常见急重症的治疗中得到了广泛应用。本文就严重烧伤机体的免疫系统变化和炎症反应原理及乌司他丁在临床治疗严重烧伤中的应用现状做一综述。

Abstract: When the organism is subjected to intense or persistent stimuli such as severe burns, the body’s regulatory capacity may be insufficient, leading to excessive stress and uncontrolled inflammation. This results in damage to the immune system, with many immune cells and molecules involved in regulation exhibiting abnormal expression or dysfunction, ultimately manifesting as immune dysregulation. Ulinastatin is an endogenous broad-spectrum protease inhibitor that possesses the ability to inhibit various proteases, stabilize the cell membrane system, improve microcirculation, and modulate immune responses. Its nonspecific anti-inflammatory effects have led to its widespread use in the clinical treatment of common acute and critical conditions such as burns and systemic inflammatory response syndrome. This article provides a review of the changes in the immune system and the principles of inflammatory response in organisms with severe burns, as well as the current status of ulinastatin application in the clinical treatment of severe burns.