不同方式治疗胰腺假性囊肿的临床进展
Clinical Advances in the Treatment of Pancreatic Pseudocysts in Different Modalities
DOI: 10.12677/acm.2025.1551449, PDF,   
作者: 邓翰煊*, 宿华威#:哈尔滨医科大学附属第二医院普通外科七病房,黑龙江 哈尔滨
关键词: 胰腺假性囊肿保守治疗腹腔镜内引流Pancreatic Pseudocyst Conservative Treatment Laparoscope Internal Drainage
摘要: 急性胰腺炎作为临床诊疗中一种常见的疾病,近年来其发病率总体呈上升趋势,对患者的身心健康及日常生活产生了诸多消极的影响。急性胰腺炎患者除去其典型的症状及体征,可在治疗过程中继发多种并发症。其中胰腺假性囊肿被认为是急性胰腺炎后期或慢性胰腺炎中众多常见的并发症之一。因部分较小的胰腺假性囊肿经过保守治疗后可自行吸收,学术界将其定义为一种自限性疾病。然而,当胰腺假性囊肿持续增大甚至出现胃肠道压迫及其他严重并发症时,需要采取不同的介入治疗方法来减轻症状,最终达到治愈。在多种介入治疗方法中,经皮穿刺置管引流(外引流)以其操作简单易行,在符合条件的患者群体中有一定的应用价值。但随着近年来内镜及超声内镜技术的不断发展和完善,内镜下经胃肠道壁穿刺置管引流术、内镜下经十二指肠乳头穿刺囊肿置管引流术、超声胃镜引导下经胃肠道壁穿刺置管引流术等新型介入方法因其具有引流部位的确定精确可靠、临床效果显著、并发症少等优点而越来越多地被应用于临床诊疗,并获得了临床医生及患者的肯定。当上述介入操作方法效果不佳时,外科手术也不失为一项有效的手段。
Abstract: As a common disease in clinical diagnosis and treatment, the incidence rate of acute pancreatitis is on the rise in recent years, which has a lot of negative effects on the physical and mental health and daily life of patients. Patients with acute pancreatitis may develop multiple complications during the treatment process, apart from their typical symptoms and signs. Among them, pancreatic pseudocyst is considered one of the many common complications in the late stage of acute pancreatitis or chronic pancreatitis. Due to the fact that a small number of pancreatic pseudocysts can self absorb after conservative treatment, the academic community defines it as a self limiting disease. However, when pancreatic pseudocysts continue to grow and even experience gastrointestinal compression and other serious complications, different interventional treatment methods are needed to alleviate symptoms and ultimately achieve cure. Among various interventional treatment methods, percutaneous puncture catheter drainage (external drainage) has certain application value in eligible patient populations due to its simple and feasible operation. However, with the continuous development and improvement of endoscopic and endoscopic ultrasound technology in recent years, new intervention methods such as endoscopic gastrointestinal wall puncture drainage, endoscopic duodenal papilla puncture cyst puncture drainage, and ultrasound-guided gastrointestinal wall puncture drainage have been increasingly applied in clinical diagnosis and treatment due to their advantages of accurate and reliable determination of drainage sites, significant clinical effects, and fewer complications, and have been recognized by clinical doctors and patients. When the above intervention methods are ineffective, surgical intervention can also be an effective means.
文章引用:邓翰煊, 宿华威. 不同方式治疗胰腺假性囊肿的临床进展[J]. 临床医学进展, 2025, 15(5): 904-910. https://doi.org/10.12677/acm.2025.1551449

参考文献

[1] D’Egidio, A. and Schein, M. (1991) Pancreatic Pseudocysts: A Proposed Classification and Its Management Implications. Journal of British Surgery, 78, 981-984. [Google Scholar] [CrossRef] [PubMed]
[2] Kim, Y.H., Saini, S., Sahani, D., Hahn, P.F., Mueller, P.R. and Auh, Y.H. (2005) Imaging Diagnosis of Cystic Pancreatic Lesions: Pseudocyst versus Nonpseudocyst. RadioGraphics, 25, 671-685. [Google Scholar] [CrossRef] [PubMed]
[3] Pop, F., Găvan, T., Maxim, C., Sorescu, S. and Vlad, L. (2004) Pancreatic Pseudocyst Diagnosis, Evolution, Surgical Treatment. Chirurgia, 99, 131-137. (In Hungarian)
[4] Yeo, C.J., Bastidas, J.A., Lynch Nyhan, A., Fishman, E.K., Zinner, M.J. and Cameron, J.L. (1990) The Natural History of Pancreatic Pseudocysts Documented by Computed Tomography. Surgery, Gynecology and Obstetrics, 170, 411-417.
[5] Rabie, M.E., Hakeem, I.E., Skaini, M.S.A., Hadad, A.E., Jamil, S., Shah, M.T., et al. (2014) Pancreatic Pseudocyst or a Cystic Tumor of the Pancreas? Chinese Journal of Cancer, 33, 87-95. [Google Scholar] [CrossRef] [PubMed]
[6] Case, B.M., Jensen, K.K., Bakis, G., Enestvedt, B.K., Shaaban, A.M. and Foster, B.R. (2018) Endoscopic Interventions in Acute Pancreatitis: What the Advanced Endoscopist Wants to Know. RadioGraphics, 38, 2002-2018. [Google Scholar] [CrossRef] [PubMed]
[7] De Angelis, P., Romeo, E., Rea, F., Torroni, F., Caldaro, T., Federici di Abriola, G., Foschia, F., Caloisi, C., Lucidi, V. and Dall’o-glio, L. (2013) Miniprobe EUS in Management of Pancreatic Pseudocyst. World Journal of Gastrointestinal Endoscopy, 5, 255-260.
[8] Zerem, E., Hauser, G., Loga-Zec, S., Kunosić, S., Jovanović, P. and Crnkić, D. (2015) Minimally Invasive Treatment of Pancreatic Pseudocysts. World Journal of Gastroenterology, 21, 6850-6860. [Google Scholar] [CrossRef] [PubMed]
[9] Cheruvu, C., Clarke, M., Prentice, M. and Eyre-Brook, I. (2003) Conservative Treatment as an Option in the Management of Pancreatic Pseudocyst. Annals of The Royal College of Surgeons of England, 85, 313-316. [Google Scholar] [CrossRef] [PubMed]
[10] Byrne, M.F., Mitchell, R.M. and Baillie, J. (2002) Pancreatic pseudocysts. Current Treatment Options in Gastroenterology, 5, 331-338. [Google Scholar] [CrossRef] [PubMed]
[11] Yeo, C.J., Bastidas, J.A., Lynch-Nyhan, A., Fishman, E.K., Zinner, M.J. and Cameron, J.L. (1990) The Natural History of Pancreatic Pseudo-Cysts Documented by Computed Tomography. Surgery, Gynecology and Obstetrics, 170, 411-417.
[12] Vitas, G.J., Vrge, S., Dewitt, J., et al. (2013) Acute Pancreatitis: Guidelines for the American College of Gastroenterology. Gastroenterol, 108, 1400-1415.
[13] Yu, B. (2018) Advances in the Treatment of Pancreatic Pseudocyst. Chinese Journal of Minimally Invasive Surgery, 18, 636. (In Chinese)
[14] Marino, K.A., Hendrick, L.E. and Behrman, S.W. (2016) Surgical Management of Complicated Pancreatic Pseudocysts after Acute Pancreatitis. The American Journal of Surgery, 211, 109-114. [Google Scholar] [CrossRef] [PubMed]
[15] 刘扬, 何俊峰, 吕运梅, 李爱华, 闫国珍. 超声引导下经皮穿刺置管序贯治疗对老年胰腺假性囊肿的临床疗效分析[J]. 中外医疗, 2018, 37(24): 182-184.
[16] Alhasan, F., Hoilat, G.J., Malas, W., Mahmood, S.K., Zivny, J. and Alsayid, M. (2019) Endoscopic Management of Giant Walled-Off Pancreatic Necrosis with a High Risk of Bleeding. ACG Case Reports Journal, 6, e00199. [Google Scholar] [CrossRef] [PubMed]
[17] 里子彧, 曹军英, 张筠, 等. 超声引导下经皮穿刺双管引流在治疗巨大胰腺假性囊肿中应用[J]. 临床军医杂志, 2018, 46(1): 28-30.
[18] 李丛祥, 张艳青, 赵军, 等. 超声内镜引导下内引流与经皮穿刺引流治疗胰腺假性囊肿疗效比较的荟萃分析[J]. 中华胰腺病杂志, 2023, 23(4): 283-289.
[19] Misra, D. and Sood, T. (2024) Pancreatic Pseudocyst. StatPearls.
[20] Tan, J.H., Chin, W., Shaikh, A.L. and Zheng, S. (2020) Pancreatic Pseudocyst: Dilemma of Its Recent Management (Review). Experimental and Therapeutic Medicine, 21, Article No. 159. [Google Scholar] [CrossRef] [PubMed]
[21] 刘树荣, 何三光, 刘永锋, 等. 胰腺囊肿术式探讨及疗效评价(附118例报告) [J]. 中华肝胆外科杂志, 1998(6): 378-380.
[22] Rosso, E., Alexakis, N., Ghaneh, P., Lombard, M., Smart, H.L., Evans, J., et al. (2003) Pancreatic Pseudocyst in Chronic Pancreatitis: Endoscopic and Surgical Treatment. Digestive Surgery, 20, 397-406. [Google Scholar] [CrossRef] [PubMed]
[23] 余波. 胰腺假性囊肿治疗的研究进展[J]. 中国微创外科杂志, 2018, 18(7): 636-638.
[24] Hao, W., Chen, Y., Jiang, Y. and Yang, A. (2021) Endoscopic Versus Laparoscopic Treatment for Pancreatic Pseudocysts: A Systematic Review and Meta-Analysis. Pancreas, 50, 788-795. [Google Scholar] [CrossRef] [PubMed]
[25] Varadarajulu, S., Christein, J.D. and Wilcox, C.M. (2011) Frequency of Complications during EUS‐Guided Drainage of Pancreatic Fluid Collections in 148 Consecutive Patients. Journal of Gastroenterology and Hepatology, 26, 1504-1508. [Google Scholar] [CrossRef] [PubMed]
[26] Pereira, F., Caldeira, A., Leite, S., Marques, S., Moreira, T., Moutinho-Ribeiro, P., et al. (2020) GRUPUGE Perspective: Endoscopic Ultrasound-Guided Drainage of Peripancreatic Collections. GEPortuguese Journal of Gastroenterology, 28, 39-51. [Google Scholar] [CrossRef] [PubMed]
[27] Nabi, Z. and Lakhtakia, S. (2021) Endoscopic Management of Chronic Pancreatitis. Digestive Endoscopy, 33, 1059-1072. [Google Scholar] [CrossRef] [PubMed]
[28] Nabi, Z., Basha, J. and Reddy, D.N. (2017) Endoscopic Management of Pancreatic Fluid Collections-Revisited. World Journal of Gastroenterology, 23, 2660-2672. [Google Scholar] [CrossRef] [PubMed]
[29] Shekhar, C., Maher, B., Forde, C. and Mahon, B.S. (2017) Endoscopic Ultrasound-Guided Pancreatic Fluid Collections’ Transmural Drainage Outcomes in 100 Consecutive Cases of Pseudocysts and Walled off Necrosis: A Single-Centre Experience from the United Kingdom. Scandinavian Journal of Gastroenterology, 53, 611-615. [Google Scholar] [CrossRef] [PubMed]
[30] Adler, D., Mohan, B., Shakhatreh, M., Dugyala, S., Geedigunta, V., Gadalay, A., et al. (2019) EUS versus Percutaneous Management of Postoperative Pancreatic Fluid Collection: A Systematic Review and Meta-Analysis. Endoscopic Ultrasound, 8, 298-309. [Google Scholar] [CrossRef] [PubMed]
[31] Frantzides, C.T., Ludwig, K.A. and Redlich, P.N. (1994) Laparoscopic Management of a Pancreatic Pseudocyst. Journal of Laparoendoscopic Surgery, 4, 55-59. [Google Scholar] [CrossRef] [PubMed]
[32] Wu, T., Jin, Z., He, Q., Zhao, X., Kou, J. and Fan, H. (2017) Treatment of Retrogastric Pancreatic Pseudocysts by Laparoscopic Transgastric Cystogastrostomy. Current Medical Science, 37, 726-731. [Google Scholar] [CrossRef] [PubMed]
[33] Ye, J., Wang, L., Lu, S., Yang, D., Hu, W., Lu, H., et al. (2021) Clinical Study on Cystogastrostomy and Roux-En-Y-Type Cystojejunostomy in the Treatment of Pancreatic Pseudocyst: A Single-Center Experience. Medicine, 100, e25029. [Google Scholar] [CrossRef] [PubMed]
[34] 姜为. 胰腺假性囊肿外科治疗方式的选择及优效性分析[D]: [硕士学位论文]. 长春: 吉林大学, 2024.
[35] Palanivelu, C., Senthilkumar, K., Madhankumar, M.V., Rajan, P.S., Shetty, A.R., Jani, K., et al. (2007) Management of Pancreatic Pseudocyst in the Era of Laparoscopic Surgery—Experience from a Tertiary Centre. Surgical Endoscopy, 21, 2262-2267. [Google Scholar] [CrossRef] [PubMed]
[36] Farias, G.F.A., Bernardo, W.M., De Moura, D.T.H., Guedes, H.G., Brunaldi, V.O., Visconti, T.A.D.C., et al. (2019) Endoscopic versus Surgical Treatment for Pancreatic Pseudocysts: Systematic Review and Meta-Analysis. Medicine, 98, e14255. [Google Scholar] [CrossRef] [PubMed]
[37] Stutchfield, B.M., Joseph, S., Duckworth, A.D., Garden, O.J. and Parks, R.W. (2009) Distal Pancreatectomy: What Is the Standard for Laparoscopic Surgery? HPB, 11, 210-214. [Google Scholar] [CrossRef] [PubMed]
[38] 戴梦华, 石宁, 刘尚龙, 等. 腹腔镜保留脾脏胰体尾切除术[J]. 中华普外科手术学杂志(电子版), 2013, 7(3): 183-185.
[39] Wang, Y., Omar, Y.A., Agrawal, R. and Gong, Z. (2019) Comparison of Treatment Modalities in Pancreatic Pseudocyst: A Population Based Study. World J Gastrointest Surg, 11, 365-372. [Google Scholar] [CrossRef] [PubMed]
[40] Crisanto-Campos, B.A., Rojano-Rodríguez, M.E., Cárdenas-Lailson, L.E., Gallardo-Ramírez, M.A., Arrieta-Joffe, P., Márquez-Ugalde, M.A., et al. (2012) Drenaje laparoscópico de un seudoquiste pancreático: Reporte de caso. Revista de Gastroenterología de México, 77, 148-152. [Google Scholar] [CrossRef] [PubMed]
[41] Matsuoka, L. and Alexopoulos, S.P. (2018) Surgical Management of Pancreatic Pseudocysts. Gastrointestinal Endoscopy Clinics of North America, 28, 131-141. [Google Scholar] [CrossRef] [PubMed]
[42] 孙利慧, 王新, 张筱茵. 超声内镜在胰腺假性囊肿治疗中的进展[J]. 实用医学杂志, 2018, 34(10): 1743-1745.
[43] Qu, Y.C., Yang, J.F. and Zhang, X.F. (2021) Research Progress of Endoscopic Ultrasonography-Guided Stent Drainage for Pancreatic Walled-Off Necrosis. Chinese Journal of Digestive Endoscopy, 38, 582-585. (In Chinese)