中医治法治疗血管性痴呆研究进展
Research Progress of Traditional Chinese Medicine Therapies for the Treatment of Vascular Dementia
DOI: 10.12677/acm.2025.1551471, PDF,   
作者: 张 纯, 张雯慧, 张虎啸：黑龙江中医药大学研究生院，黑龙江 哈尔滨；窦金金*：黑龙江中医药大学附属第四医院心内一，黑龙江 哈尔滨
关键词: 血管性痴呆；机制；中药；针刺；艾灸；Vascular Dementia； Mechanism； Chinese Herbs； Acupuncture； Moxibustion
摘要: 血管性痴呆(vascular dementia, VD)是一种认知、学习能力减退为特征的综合征，严重影响患者的生活质量。目前西医认为VD发生机制与氧化应激、炎症反应、细胞凋亡等密切相关，西医治疗主要依赖于昂贵的西药，但弊端也显而易见，如其存在药物副作用，并且疗效也存在个体差异。中医认为痴呆的发生与肾精空虚、脑髓失充，痰浊痹阻、瘀血阻止，火毒内生密切相关。临床中应用中医药治疗VD得到良好治疗效果，且可以做到个体化治疗。本文将从VD发病机制及中药、针刺、艾灸等中医治法治疗VD的机制及疗效等方面探讨，为今后临床治疗VD开拓思路。
Abstract: Vascular dementia (VD) is a syndrome characterized by a decline in cognitive and learning abilities, which significantly impacts the quality of life of patients. Currently, Western medicine attributes the pathogenesis of VD to factors such as oxidative stress, inflammatory responses, and apoptosis. Treatment in Western medicine primarily relies on expensive medications, but their drawbacks are evident, including side effects and individual variations in efficacy. Traditional Chinese medicine (TCM) believes that the occurrence of dementia is closely related to deficiencies in kidney essence and brain marrow, obstruction by phlegm and blood stasis, and the endogenous generation of fire and toxins. In clinical practice, the application of TCM for VD has yielded favorable therapeutic effects and allows for individualized treatment. This article will explore the pathogenesis of VD and the mechanisms and efficacy of TCM therapies such as Chinese herbs, acupuncture, and moxibustion in treating VD, with the aim of providing new insights for future clinical treatment of VD.
文章引用：张纯, 张雯慧, 张虎啸, 窦金金. 中医治法治疗血管性痴呆研究进展[J]. 临床医学进展, 2025, 15(5): 1097-1108. https://doi.org/10.12677/acm.2025.1551471

参考文献

[1] 余文骁, 王延江. 亚洲血管性认知损害的流行病学现状和发展趋势[J]. 中国医学前沿杂志(电子版), 2020, 12(10): 1-8.
[2] 马莉, 王诗陶, 刘征. 电针额区对血管性痴呆大鼠行为学及脑内cAMP-PKA-CREB信号通路的影响[J]. 针灸临床杂志, 2017, 33(1): 50-52.
[3] 林龙, 吴林, 劳祎林, 等. 中医药复方干预血管性痴呆的作用及机制[J]. 中华中医药学刊, 2023, 41(6): 111-114.
[4] 王飞雪, 黄小波, 裴卉, 等. 血管性痴呆中医病机理论的传承和发扬[J]. 世界中医药, 2022, 17(2): 221-224+228.
[5] Lyu, Y., Meng, Z., Hu, Y., Jiang, B., Yang, J., Chen, Y., et al. (2024) Corrigendum: Mechanisms of Mitophagy and Oxidative Stress in Cerebral Ischemia-Reperfusion, Vascular Dementia, and Alzheimer’s Disease. Frontiers in Molecular Neuroscience, 17, Article ID: 1394932. [Google Scholar] [CrossRef] [PubMed]
[6] Zhang, C., Chang, X., Zhao, D., He, Y., Dong, G. and Gao, L. (2025) Mitochondria and Myocardial Ischemia/Reperfusion Injury: Effects of Chinese Herbal Medicine and the Underlying Mechanisms. Journal of Pharmaceutical Analysis, 15, Article ID: 101051. [Google Scholar] [CrossRef] [PubMed]
[7] Cai, H., Cai, T., Zheng, H., Liu, L., Zhou, L., Pang, X., et al. (2020) The Neuroprotective Effects of Danggui-Shaoyao San on Vascular Cognitive Impairment: Involvement of the Role of the Low-Density Lipoprotein Receptor-Related Protein. Rejuvenation Research, 23, 420-433. [Google Scholar] [CrossRef] [PubMed]
[8] Poh, L., Sim, W.L., Jo, D., Dinh, Q.N., Drummond, G.R., Sobey, C.G., et al. (2022) The Role of Inflammasomes in Vascular Cognitive Impairment. Molecular Neurodegeneration, 17, Article No. 4. [Google Scholar] [CrossRef] [PubMed]
[9] Lamkanfi, M. and Dixit, V.M. (2014) Mechanisms and Functions of Inflammasomes. Cell, 157, 1013-1022. [Google Scholar] [CrossRef] [PubMed]
[10] Zhong, G., Wang, X., Zhang, Q., Zhang, X., Fang, X., Li, S., et al. (2024) Exploring the Therapeutic Implications of Natural Compounds Modulating Apoptosis in Vascular Dementia. Phytotherapy Research, 38, 5270-5289. [Google Scholar] [CrossRef] [PubMed]
[11] 辛晶晶, 杨阳. 神经细胞凋亡与血管性痴呆疾病关系的研究进展[J]. 医学研究与战创伤救治, 2023, 36(3): 324-327.
[12] Duan, R., Hou, J., Wang, X., Huang, Z., Cao, H., Hu, J., et al. (2023) Prevotella Histicola Transplantation Ameliorates Cognitive Impairment and Decreases Oxidative Stress in Vascular Dementia Rats. Brain Sciences, 13, Article No. 1136. [Google Scholar] [CrossRef] [PubMed]
[13] Ningning, Y., Ying, X., Xiang, L., Yue, S., Zhongda, W., Ruoyu, J., et al. (2024) Danggui-Shaoyao San Alleviates Cognitive Impairment via Enhancing HIF-1α/EPO Axis in Vascular Dementia Rats. Journal of Ethnopharmacology, 331, Article ID: 118306. [Google Scholar] [CrossRef] [PubMed]
[14] Piao, X., Zhang, H., Kang, J.P., Yang, D.U., Li, Y., Pang, S., et al. (2020) Advances in Saponin Diversity of Panax Ginseng. Molecules, 25, Article No. 3452. [Google Scholar] [CrossRef] [PubMed]
[15] Feng, H., Xue, M., Deng, H., Cheng, S., Hu, Y. and Zhou, C. (2022) Ginsenoside and Its Therapeutic Potential for Cognitive Impairment. Biomolecules, 12, Article No. 1310. [Google Scholar] [CrossRef] [PubMed]
[16] Madhi, I., Kim, J., Shin, J.E. and Kim, Y. (2021) Ginsenoside Re Exhibits Neuroprotective Effects by Inhibiting Neuroinflammation via CAMK/MAPK/NFκB Signaling in Microglia. Molecular Medicine Reports, 24, Article No. 698. [Google Scholar] [CrossRef] [PubMed]
[17] Sun, M., Shen, X. and Ma, Y. (2019) Rehmannioside a Attenuates Cognitive Deficits in Rats with Vascular Dementia (VD) through Suppressing Oxidative Stress, Inflammation and Apoptosis. Biomedicine & Pharmacotherapy, 120, Article ID: 109492. [Google Scholar] [CrossRef] [PubMed]
[18] Han, G.H., et al. (2022) Dihuang-Yinzi Alleviates Cognition Deficits via Targeting Energy-Related Metabolism in an Alzheimer Mouse Model as Demonstrated by Integration of Metabolomics and Network Pharmacology. Frontiers in Aging Neuroscience, 14, Article ID: 873929.
[19] 周雨慧, 苗明三, 芦锰, 等. 地黄饮子加减方对血管性痴呆模型大鼠学习记忆能力及海马CA1区神经元损伤的影响[J]. 中国实验方剂学杂志, 2020, 26(8): 53-61.
[20] 周开俊, 杨志宏, 周悦, 等. 基于PI3K/Akt信号通路的中医药治疗血管性痴呆的研究进展[J]. 中国医药导报, 2023, 20(34): 48-52.
[21] Wang, S., Huang, J., Chen, Y., Liang, Y., Chen, L., Ye, D., et al. (2024) Qifu-Yin Activates the Keap1/Nrf2/Are Signaling and Ameliorates Synaptic Injury and Oxidative Stress in APP/PS1 Mice. Journal of Ethnopharmacology, 333, Article ID: 118497. [Google Scholar] [CrossRef] [PubMed]
[22] Cheng, J., Li, W., Wang, L., Gao, Y., Ma, Y., Zhou, M., et al. (2024) Jiawei Qifuyin Enhances Immunity and Improves Cognitive Impairment in APP/PS1 Mice through Modulation of Neuroinflammatory Pathways. Journal of Inflammation Research, 17, 9021-9040. [Google Scholar] [CrossRef] [PubMed]
[23] 秦晓颖, 陈文静, 刘玉萍, 等. 和厚朴酚与厚朴酚治疗免疫紊乱疾病及其免疫调控作用研究进展[J]. 中草药, 2024, 55(24): 8602-861.
[24] 李阳阳, 方建, 王晓雪. 和厚朴酚调节BDNF-TrkB-CREB信号通路对脑出血小鼠神经损伤和认知功能的影响[J]. 中国卒中杂志, 2024, 19(9): 1048-1057.
[25] Bailly, C. (2021) Atractylenolides, Essential Components of Atractylodes-Based Traditional Herbal Medicines: Antioxidant, Anti-Inflammatory and Anticancer Properties. European Journal of Pharmacology, 891, Article ID: 173735. [Google Scholar] [CrossRef] [PubMed]
[26] 高琛, 孙峰山, 李娜. 白术内酯Ⅲ调节PERK-eIF2α-ATF4信号通路介导内质网应激对脑缺血-再灌注损伤大鼠神经细胞凋亡的影响[J]. 中药材, 2024(10): 2615-2619.
[27] Liu, G., Xie, R., Tan, Q., Zheng, J., Li, W., Wang, Q., et al. (2024) Pharmacokinetic Study and Neuropharmacological Effects of Atractylenolide III to Improve Cognitive Impairment via PI3K/AKT/GSK3β Pathway in Intracerebroventricular-Streptozotocin Rats. Journal of Ethnopharmacology, 333, Article ID: 118420. [Google Scholar] [CrossRef] [PubMed]
[28] 丁瑞丛, 王峰, 徐晓玉, 等. 涤痰汤加味方对血管性痴呆认知功能、相关炎性指标的改善及影响[J]. 中华中医药学刊, 2024, 42(7): 96-100.
[29] 杨超, 杨佳, 刘玲. 涤痰汤对血管性痴呆大鼠海马TNF-α、NF-κB、IL-1β、IL-10表达的影响[J]. 中国老年学杂志, 2021, 41(17): 3796-3799.
[30] 丁瑞丛, 纪可, 吴东南, 等. 涤痰汤加味方对血管性痴呆大鼠行为学及PKA/CREB信号通路的影响[J]. 中国中西医结合杂志, 2021, 41(3): 364-369.
[31] 杨超, 杨佳, 刘玲. 涤痰汤对血管性痴呆大鼠海马NOX2/ROS通路、GSH、HO-1表达的影响[J]. 中国老年学杂志, 2019, 39(12): 3052-3055.
[32] Wen, L., Cheng, X., Fan, Q., Chen, Z., Luo, Z., Xu, T., et al. (2023) Tanshinoneⅱa Inhibits Excessive Autophagy and Protects Myocardium against Ischemia/Reperfusion Injury via 14-3-3η/Akt/Beclin1 Pathway. European Journal of Pharmacology, 954, Article ID: 175865. [Google Scholar] [CrossRef] [PubMed]
[33] Song, Z.B., et al. (2021) Tanshinone IIA Protects against Cerebral Ischemia Reperfusion Injury by Regulating Microglial Activation and Polarization via NF-κB Pathway. Frontiers in Pharmacology, 12, Article ID: 641848.
[34] Lin, J., Wang, Q., Zhou, S., Xu, S. and Yao, K. (2022) Tetramethylpyrazine: A Review on Its Mechanisms and Functions. Biomedicine & Pharmacotherapy, 150, Article ID: 113005. [Google Scholar] [CrossRef] [PubMed]
[35] Mu, Q., Yao, K., Syeda, M.Z., Zhang, M., Cheng, Q., Zhang, Y., et al. (2023) Ligustrazine Nanoparticle Hitchhiking on Neutrophils for Enhanced Therapy of Cerebral Ischemia‐Reperfusion Injury. Advanced Science, 10, e2301348. [Google Scholar] [CrossRef] [PubMed]
[36] 陈应奇, 刘英莲, 梁薇, 等. 丹参-川芎药对干预大鼠血管性痴呆作用机制[J]. 陕西中医, 2024, 45(3): 297-301.
[37] 朱云鹤, 吴云虎, 方向. 通窍活血汤治疗瘀血内阻型血管性认知障碍的临床观察[J]. 中国实验方剂学杂志, 2019, 25(2): 139-143.
[38] Li, J., Ye, H., Xu, F., Yang, Y., Ge, C., Yao, M., et al. (2024) Tong-Qiao-Huo-Xue Decoction Promotes Synaptic Remodeling via CAMP/PKA/CREB Pathway in Vascular Dementia Rats. Phytomedicine, 135, Article ID: 156166. [Google Scholar] [CrossRef] [PubMed]
[39] 许鑫, 张原愿. 通窍活血汤加减治疗血管性痴呆的临床效果及对脑循环动力学的影响[J]. 中药材, 2023, 46(7): 1793-1797.
[40] 刘红淼, 李艳玲, 刘欢, 等. 通窍活血汤对血管性痴呆大鼠学习记忆及海马PI3K/Akt信号通路的影响[J]. 中国实验方剂学杂志, 1-8.
[41] 刘婉沂, 张英丰, 周欣, 等. 补阳还五汤抗脑缺血的作用机制研究进展[J]. 中药新药与临床药理, 2022, 33(3): 411-418.
[42] Yang, K., Zeng, L., Ge, A., Yi, Y., Wang, S. and Ge, J. (2021) Exploring the Oxidative Stress Mechanism of Buyang Huanwu Decoction in Intervention of Vascular Dementia Based on Systems Biology Strategy. Oxidative Medicine and Cellular Longevity, 2021, Article ID: 8879060. [Google Scholar] [CrossRef] [PubMed]
[43] Xue, B., Ma, B., Yao, Y., Zhao, A., Gao, Y. and Liu, J. (2022) BYHW Decoction Improves Cognitive Impairments in Rats with Cerebral Microinfarcts via Activation of the PKA/CREB Pathway. Oxidative Medicine and Cellular Longevity, 2022, Article ID: 4455654. [Google Scholar] [CrossRef] [PubMed]
[44] 王洋岗, 周春燕, 任惠明, 等. 电针配合加味补阳还五汤对血管性痴呆患者记忆行为学、血清BDNF、VEGF及神经元凋亡相关分子表达的影响[J]. 中华中医药学刊, 2022, 40(5): 81-84+268.
[45] 张运辉, 杨梦琳, 伍大华, 等. 基于网络药理学和实验验证探讨黄连解毒汤治疗血管性痴呆的作用机制[J]. 天然产物研究与开发, 2023, 35(3): 509-518+549.
[46] Xiong, R., Huang, S., Wu, S., Zhou, D., Yang, Z., Saimaiti, A., et al. (2022) Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review. Molecules, 27, Article No. 4523. [Google Scholar] [CrossRef] [PubMed]
[47] Yin, S., Bai, W., Li, P., Jian, X., Shan, T., Tang, Z., et al. (2018) Berberine Suppresses the Ectopic Expression of Mir-133a in Endothelial Cells to Improve Vascular Dementia in Diabetic Rats. Clinical and Experimental Hypertension, 41, 708-716. [Google Scholar] [CrossRef] [PubMed]
[48] Sulistyowati, E., Huang, S., Cheng, T., Chao, Y., Li, C., Chang, C., et al. (2023) Vasculoprotective Potential of Baicalein in Angiotensin II-Infused Abdominal Aortic Aneurysms through Inhibiting Inflammation and Oxidative Stress. International Journal of Molecular Sciences, 24, Article No. 16004. [Google Scholar] [CrossRef] [PubMed]
[49] Song, J., Li, M., Kang, N., Jin, W., Xiao, Y., Li, Z., et al. (2024) Baicalein Ameliorates Cognitive Impairment of Vascular Dementia Rats via Suppressing Neuroinflammation and Regulating Intestinal Microbiota. Brain Research Bulletin, 208, Article ID: 110888. [Google Scholar] [CrossRef] [PubMed]
[50] 冯宇博, 陈好, 张相安. 黄连解毒汤现代临床应用和作用机制研究进展[J/OL]. 辽宁中医药大学学报, 1-19.
http://kns.cnki.net/kcms/detail/21.1543.R.20241119.1406.010.html, 2025-01-22.
[51] 冯小霞, 陈晨, 邱静, 等. 黄连解毒汤调控FBXL5/IRP2改善VaD小鼠脑铁代谢紊乱、髓鞘损伤及激越攻击行为[J]. 中国实验方剂学杂志, 2024, 30(24): 1-9.
[52] 樊郑翠, 颜靖岚, 胡逸君, 等. 大数据时代下的针灸研究——构建经络体表刺激的脑映射图谱[J]. 中国针灸, 1-14.
[53] 夏帆, 陈小华, 钟静雅, 等. 头穴丛刺针法联合认知功能训练治疗轻中度血管性痴呆[J]. 吉林中医药, 2025, 45(1): 109-112.
[54] 郭亭廷, 嵇波, 刘翼天, 等. 基于数据挖掘的电针及经颅电刺激治疗痴呆刺激参数应用规律研究[J]. 上海中医药杂志, 2023, 57(4): 65-71.
[55] 贾晓钰, 李惠菁, 饶婷, 等. 电针“百会” “神庭”对血管性痴呆大鼠认知障碍和线粒体能量代谢的影响[J/OL]. 针刺研究, 1-16.
http://kns.cnki.net/kcms/detail/11.2274.R.20240428.1210.006.html, 2024-12-18.
[56] Ma, C., Zhou, Y., Yi, W., Zhou, X., Guo, W., Xu, X., et al. (2022) Electroacupuncture of the Baihui and Shenting Acupoints for Vascular Dementia in Rats through the Mir-81/Il-16/Psd-95 Pathway. Annals of Translational Medicine, 10, 540-540. [Google Scholar] [CrossRef] [PubMed]
[57] Su, K.Q., et al. (2022) Electroacupuncture of Baihui and Shenting Ameliorates Cognitive Deficits via Pten/Akt Pathway in a Rat Cerebral Ischemia Injury Model. Frontiers in Neurology, 13, Article ID: 855362.
[58] 李霞, 朱世杰, 唐中生, 等. 电针智三针调节酪氨酸激酶受体的配体通路改善血管性痴呆的作用机制[J]. 解剖学报, 2023, 54(6): 689-694.
[59] 苏凯奇, 吕转, 吴明莉, 等. 电针对缺血再灌注后学习记忆障碍大鼠BDNF/TrkB/PI3K/Akt通路的影响及对海马神经元保护作用研究[J]. 中国全科医学, 2023, 26(33): 4187-4193.
[60] 彭彩钰, 张云燕, 赵冬梅, 等. 针灸对痴呆大鼠行为学、海马神经元凋亡蛋白的影响及机制[J]. 中国老年学杂志, 2024, 44(13): 3230-3234.
[61] 王浩宇, 陈英华, 孙玮, 等, 基于NT3/TrkC信号通路探讨电针对血管性痴呆大鼠海马突触可塑性及炎症因子的影响[J]. 海南医学院学报, 1-22.
[62] 宋元毓, 陈英华, 孙玮, 等. 电针“风池” “四神聪”介导NMDAR/CREB/BDNF信号通路改善血管性痴呆大鼠的学习记忆障碍[J]. 中国针灸, 2024, 44(12): 1409-1417.
[63] NLRP3/Caspase-1/GSDMD通路探讨电针“四神聪” “风池”改善血管性痴呆大鼠认知功能障碍的作用机制[J]. 海南医学院学报, 2024, 30(21): 1607-1616.
[64] 刘伟, 杨金月, 李馨悦, 等. 基于复杂网络技术分析针灸治疗血管性痴呆的配穴规律[J]. 上海针灸杂志, 2023, 42(8): 869-875.
[65] Ye, X.H., et al. (2023) Effects of Electroacupuncture at Baihui and Dazhui on Perioperative Neurocognitive Impairment and S100-β, LC3-II, Beclin-1 in Patients with Colon Cancer. American Journal of Translational Research, 15, 4237-4245.
[66] 翟丽静, 王婧, 秦卓, 等. 电针三阴交对AD小鼠学习记忆能力及海马区Ach、AchE、ChAT的影响[J]. 长春中医药大学学报, 2017, 33(2): 181-184.
[67] 梁慧英, 廖琳, 游国清, 等. 电针对血管性痴呆大鼠记忆力及海马BDNF、PSD-95蛋白表达的影响[J]. 中国康复医学杂志, 2019, 34(8): 902-906+949.
[68] 郭菲, 张素钊, 陈世雨, 等. 电针对血管性痴呆大鼠海马区c-Jun氨基末端激酶信号通路的影响[J]. 针刺研究, 2020, 45(1): 21-26.
[69] 张子玥, 嵇波, 刘翼天, 等. 电针对围产期尼古丁暴露子代大鼠记忆和认知损伤影响的机制探讨[J]. 针刺研究, 2023, 48(12): 1218-1226.
[70] 毕天威, 徐子绚, 宋杰, 等. 基于TLR-4/MyD88/NF-κB通路探讨针刺改善血管性痴呆大鼠认知功能的机制[J]. 世界科学技术-中医药现代化, 2023, 25(12): 4032-4038.
[71] 廖晶晶, 朱雅琪, 何诚, 等. 针刺通过调控高迁移率族蛋白1/晚期糖基化终末产物受体信号通路对血管性痴呆大鼠认知功能和神经炎症的影响[J]. 河北中医, 2024, 46(12): 2010-2016+2023.
[72] 徐子绚, 宋杰, 王平, 等. 针刺调节胆碱能神经递质对血管性痴呆大鼠神经保护作用的机制[J]. 中华中医药杂志, 2024, 39(11): 5833-5838.
[73] 钱颖, 邵钰柔, 卢圣锋, 等. 中医药治疗阿尔茨海默症的研究进展[J]. 南京中医药大学学报, 2019, 35(6): 761-766.
[74] 荣孟颖, 杜宇征, 谷文龙, 等. 特色针法治疗卒中后认知障碍研究进展[J]. 中国中医急症, 2023, 32(5): 933-936.
[75] 杨琼, 戴桃李, 潘娅, 等. 针刺耳穴对血管性痴呆大鼠学习记忆及海马胆碱乙酰转移酶表达的影响[J]. 中国老年学杂志, 2015, 35(23): 6712-6714.
[76] 李丹, 任路, 李默, 等. 艾灸补肾温阳疗法治疗围绝经期抑郁症[J]. 辽宁中医杂志, 2015, 42(12): 2412-2414.
[77] 侯思宁, 任路, 荆秦, 等. 基于线粒体能量代谢探讨艾灸治疗肾阳虚抑郁症的机制研究[J/OL]. 时珍国医国药, 1-4.
http://kns.cnki.net/kcms/detail/42.1436.R.20241126.1029.002.html, 2025-01-21.
[78] 杨坤, 宋小鸽, 阮静茹, 等. 艾灸改善血管性痴呆大鼠认知功能及对海马神经元凋亡相关蛋白的影响[J]. 中国针灸, 2021, 41(12): 1371-1378.
[79] 阮静茹, 杨坤, 宋小鸽, 等. 艾灸对血管性痴呆大鼠海马炎性因子及微管相关蛋白表达的影响[J]. 针刺研究, 2020, 45(10): 781-788.
[80] 朱才丰, 杨骏, 杨坤, 等. 通督化瘀灸法治疗血管性认知障碍临床观察[J]. 上海针灸杂志, 2013, 32(4): 242-244.
[81] Wang, P., et al. (2025) Effect of Huayu Tongluo Moxibustion on Learning-Memory Ability in Rats with Vascular Dementia Based on Hippocampal Mst1/NF-κB p65 Pathway. Chinese Acupuncture & Moxibustion, 45, 53-60.
[82] 陈琪, 黄宏敏, 许玉皎, 等. 耳穴贴压治疗血管性痴呆疗效对照观察[J]. 中国针灸, 2009, 29(2): 95-97.
[83] 王春凤, 杨明辉. 针刺联合耳穴贴压治疗血管性痴呆的疗效观察[J]. 上海针灸杂志, 2022, 41(3): 219-224.
[84] 王金侠, 白若岑, 陈民. 补肾祛痰化瘀复方联合益智散穴位贴敷对高龄肾虚痰瘀型MCI患者疗效观察[J]. 辽宁中医杂志, 2018, 45(7): 1473-1475.
[85] 侯燕, 王金侠, 陈民. 穴位贴敷联合补元聪脑汤治疗轻度认知功能障碍疗效观察[J]. 辽宁中医杂志, 2019, 46(9): 1931-1934.
[86] 罗燕. 血管性痴呆的诊断和治疗进展[J]. 国际神经病学神经外科学杂志, 2017, 44(5): 550-554.

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