糖尿病肾病血液高凝状态的治疗策略综述
A Comprehensive Review of Therapeutic Strategies for Hypercoagulable State in Diabetic Kidney Disease
DOI: 10.12677/acm.2025.1551501, PDF,   
作者: 田洋洋:山东第一医科大学(山东省医学科学院)研究生部,山东 济南;山东第一医科大学第一附属医院肾脏病科,山东 济南;刘以鹏*:山东第一医科大学第一附属医院肾脏病科,山东 济南
关键词: 糖尿病肾病血液高凝状态多靶点治疗Diabetic Kidney Disease Hypercoagulable State Multi-Target Therapy
摘要: 糖尿病肾病(diabetic kidney disease, DKD)是糖尿病(diabetes mellitus, DM)的主要微血管并发症之一。由于长期代谢异常、血流动力学改变、内皮损伤、凝血抗凝血失衡、血小板活化、纤溶系统抑制、补体系统激活、表观遗传调控等方面,DKD常伴血液高凝状态,不仅促进疾病进展,且增加心脑血管事件及下肢血栓风险,我们总结了当前DKD血液高凝的治疗策略以及发展前景,为DKD高凝状态的进一步治疗提供理论依据。
Abstract: Diabetic kidney disease (DKD) is one of the major microvascular complications of diabetes mellitus (DM) and is often characterized by a hypercoagulable state in the blood due to long-term metabolic abnormalities, hemodynamic changes, endothelial damage, imbalances in coagulation and anticoagulation, platelet activation, inhibition of the fibrinolytic system, activation of the complement system, and epigenetic regulation. This hypercoagulable state not only accelerates disease progression but also increases the risk of cardiovascular and cerebrovascular events, as well as lower limb thrombosis. In this context, we have summarized the current treatment strategies for the hypercoagulable state in diabetic kidney disease (DKD) as well as its future development prospects, providing a theoretical basis for further treatment of this condition.
文章引用:田洋洋, 刘以鹏. 糖尿病肾病血液高凝状态的治疗策略综述[J]. 临床医学进展, 2025, 15(5): 1350-1358. https://doi.org/10.12677/acm.2025.1551501

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