琥珀酸脱氢酶缺陷型肾细胞癌CT表现一例并文献复习
A Case Report of CT Manifestations of Succinate Dehydrogenase Deficient Renal Cell Carcinoma and Literature Review
DOI: 10.12677/acm.2025.1551556, PDF,   
作者: 张 烁, 彭培立, 闫宇涛*, 白守红, 李肖可, 李晓利：联勤保障部队第九八八医院影像医学科，河南 郑州
关键词: 肾细胞癌；琥珀酸脱氢酶；缺陷；CT；Renal Cell Carcinoma； Succinate Dehydrogenase； Defects； CT
摘要: 琥珀酸脱氢酶(Succinate dehydrogenase, SDH)缺陷型肾细胞癌是2016版WHO肾肿瘤分类中新增加的一种独特肾癌亚型，该亚型发病率极低，目前国内外报道较少。本文回顾1例中年女性SDH缺陷型肾细胞癌患者，以肉眼血尿8小时为主诉收治入院，CT表现右肾上极巨大实性占位性病变，收治并完善相关检查后行右肾肿瘤根治术，术后病理结果示SDH缺陷型肾细胞癌。
Abstract: Succinate dehydrogenase (SDH) deficient renal cell carcinoma is a unique subtype of renal cell carcinoma newly added in the 2016 WHO classification of renal tumors. The incidence rate of this subtype is extremely low, and there are few reports at home and abroad at present. This article reviews a middle-aged female patient with SDH deficient renal cell carcinoma. She was admitted to the hospital with a chief complaint of gross hematuria for 8 hours. CT showed a huge solid mass lesion in the upper right kidney. After admission and completion of relevant examinations, the patient underwent radical surgery for the right kidney tumor. The postoperative pathological results showed SDH deficient renal cell carcinoma.
文章引用：张烁, 彭培立, 闫宇涛, 白守红, 李肖可, 李晓利. 琥珀酸脱氢酶缺陷型肾细胞癌CT表现一例并文献复习[J]. 临床医学进展, 2025, 15(5): 1774-1780. https://doi.org/10.12677/acm.2025.1551556

参考文献

[1] Rogala, J. and Zhou, M. (2024) Hereditary Succinate Dehydrogenase-Deficient Renal Cell Carcinoma. Seminars in Diagnostic Pathology, 41, 32-41. [Google Scholar] [CrossRef] [PubMed]
[2] Kuroda, N., Yorita, K., Nagasaki, M., Harada, Y., Ohe, C., Jeruc, J., et al. (2016) Review of Succinate Dehydrogenase-Deficient Renal Cell Carcinoma with Focus on Clinical and Pathobiological Aspects. Polish Journal of Pathology, 1, 3-7. [Google Scholar] [CrossRef] [PubMed]
[3] Vanharanta, S., Buchta, M., McWhinney, S.R., Virta, S.K., Peçzkowska, M., Morrison, C.D., et al. (2004) Early-Onset Renal Cell Carcinoma as a Novel Extraparaganglial Component of SDHB-Associated Heritable Paraganglioma. The American Journal of Human Genetics, 74, 153-159. [Google Scholar] [CrossRef] [PubMed]
[4] Moch, H., Cubilla, A.L., Humphrey, P.A., Reuter, V.E. and Ulbright, T.M. (2016) The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part A: Renal, Penile, and Testicular Tumours. European Urology, 70, 93-105. [Google Scholar] [CrossRef] [PubMed]
[5] Kumar, R.A., Miyagi, H., Mittal, V., Crispen, P. and Kumar, U. (2022) Succinate Dehydrogenase Deficient Renal Cell Carcinoma: A Case Report. Urology Case Reports, 40, Article 101885. [Google Scholar] [CrossRef] [PubMed]
[6] Liu, W., Chen, G., Meng, J., Liao, X. and Xie, Y. (2023) Imaging findings of Succinate Dehydrogenase‐Deficient Renal Cell Carcinoma. Clinical Case Reports, 11, e7799. [Google Scholar] [CrossRef] [PubMed]
[7] 刘佳伟, 鲍宽主, 郝金钢. 琥珀酸脱氢酶缺陷型肾细胞癌CT、MRI表现1例[J]. 中国临床医学影像杂志, 2023, 34(1): 70-71.
[8] Sun, A., Liu, Z., Wang, T. and Xing, J. (2021) Succinate Dehydrogenase-Deficient Renal Cell Carcinoma: A Case Report and Review of the Literature. Asian Journal of Surgery, 44, 692-693. [Google Scholar] [CrossRef] [PubMed]
[9] Sun, X., Wang, G., Huang, Z., Li, P., Yang, B., Wang, T., et al. (2023) Succinate Dehydrogenase Defects Giant Renal Cell Carcinoma. Urologia Internationalis, 107, 819-822. [Google Scholar] [CrossRef] [PubMed]
[10] Higashi, S., Sasaki, T., Uchida, K., Kageyama, T., Ikejiri, M., Matsumoto, R., et al. (2022) Succinate Dehydrogenase B-Deficient Renal Cell Carcinoma with a Germline Variant in a Japanese Patient: A Case Report. Human Genome Variation, 9, Article No. 25. [Google Scholar] [CrossRef] [PubMed]
[11] Szymanski, M., Rusetska, N., Jancewicz, I., Armatowska, A., Ligaj, M., Chrzan, A., et al. (2021) Succinate Dehydrogenase-Deficient Renal Cancer Featuring Fructose-1,6-Biphosphatase Loss, Pyruvate Kinase M2 Overexpression, and SWI/SNF Chromatin Remodeling Complex Aberrations: A Rare Case Report. The Oncologist, 26, e1652-e1655. [Google Scholar] [CrossRef] [PubMed]
[12] Dai, Z., Wang, X., Zhang, Y., Qiu, Y. and Liu, J. (2024) A Highly Malignant Succinate Dehydrogenase A-Deficient Renal Cell Carcinoma with Bone Metastasis Misdiagnosed as Hereditary Leiomyomatosis and Renal Cell Carcinoma: A Case Report. Oncology Letters, 28, Article No. 351. [Google Scholar] [CrossRef] [PubMed]
[13] Dong, S., Wang, Z., Tian, X., Wang, C., Xu, Q., Xu, C., et al. (2024) Keratin 20 Positive SDH-Deficient Renal Cell Carcinoma: A Case Report and Literature Review. Diagnostic Pathology, 19, Article No. 137. [Google Scholar] [CrossRef] [PubMed]
[14] Tsai, T. and Lee, W. (2018) Succinate Dehydrogenase-Deficient Renal Cell Carcinoma. Archives of Pathology & Laboratory Medicine, 143, 643-647. [Google Scholar] [CrossRef] [PubMed]

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