成人院内心脏骤停的危险因素研究进展
Research Progress on Risk Factors of In-Hospital Cardiac Arrest in Adults
DOI: 10.12677/acm.2025.1551569, PDF,    科研立项经费支持
作者: 张鹏飞, 李 芳*:昆明医科大学第二附属医院急诊医学部,云南 昆明
关键词: 成年人院内心脏骤停心血管疾病危险因素Adult In-Hospital Cardiac Arrest Cardiovascular Diseases Risk Factors
摘要: 院内心脏骤停(in-hospital cardiac arrest, IHCA)是可能威胁任何住院患者生命安全的紧急事件。随着老龄化社会的到来,IHCA发生率及致死率、致残率逐年升高,且年龄越大预后越差。早期发现IHCA的独立危险因素是降低其发生率、提高救治成功率的关键环节。有关IHCA的研究数据却十分有限,IHCA的危险因素尚不完全清楚。本文拟就当前研究证据较多的成人IHCA危险因素做一综述,以期为临床防治IHCA和开展相关研究提供参考。
Abstract: In-hospital cardiac arrest (IHCA) is an emergency that can threaten the life of any hospitalized patient. With the advent of the aging society, the incidence, mortality and disability of IHCA increase year by year, and the older the age, the worse the prognosis. Early detection of independent risk factors of IHCA is the key to reducing its incidence and improving the success rate of treatment. Research data on IHCA are very limited, and the risk factors for IHCA are not fully understood. In this paper, the risk factors of IHCA in adults with more research evidence are reviewed in order to provide reference for clinical prevention and treatment of IHCA and related research.
文章引用:张鹏飞, 李芳. 成人院内心脏骤停的危险因素研究进展[J]. 临床医学进展, 2025, 15(5): 1872-1878. https://doi.org/10.12677/acm.2025.1551569

参考文献

[1] Hannen, L.E.M., Toprak, B., Weimann, J., Mahmoodi, B., Fluschnik, N., Schrage, B., et al. (2022) Clinical Characteristics, Causes and Predictors of Outcomes in Patients with In-Hospital Cardiac Arrest: Results from the SURVIVE-ARREST Study. Clinical Research in Cardiology, 112, 258-269. [Google Scholar] [CrossRef] [PubMed]
[2] Ohbe, H., Tagami, T., Uda, K., Matsui, H. and Yasunaga, H. (2022) Incidence and Outcomes of In-Hospital Cardiac Arrest in Japan 2011-2017: A Nationwide Inpatient Database Study. Journal of Intensive Care, 10, Article No. 10. [Google Scholar] [CrossRef] [PubMed]
[3] Allencherril, J., Lee, P.Y.K., Khan, K., Loya, A. and Pally, A. (2022) Etiologies of In-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis. Resuscitation, 175, 88-95. [Google Scholar] [CrossRef] [PubMed]
[4] Ding, X., Wang, Y., Ma, W., Peng, Y., Huang, J., Wang, M., et al. (2023) Development of Early Prediction Model of In-Hospital Cardiac Arrest Based on Laboratory Parameters. BioMedical Engineering OnLine, 22, Article No. 116. [Google Scholar] [CrossRef] [PubMed]
[5] Merchant, R.M., Topjian, A.A., Panchal, A.R., Cheng, A., Aziz, K., Berg, K.M., et al. (2020) Part 1: Executive Summary: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation, 142, S337-S357. [Google Scholar] [CrossRef] [PubMed]
[6] Kimblad, H., Marklund, J., Riva, G., Rawshani, A., Lauridsen, K.G. and Djärv, T. (2022) Adult Cardiac Arrest in the Emergency Department—A Swedish Cohort Study. Resuscitation, 175, 105-112. [Google Scholar] [CrossRef] [PubMed]
[7] Masoli, J.A.H., Mensah, E. and Rajkumar, C. (2022) Age and Ageing Cardiovascular Collection: Blood Pressure, Coronary Heart Disease and Heart Failure. Age and Ageing, 51, afac179. [Google Scholar] [CrossRef] [PubMed]
[8] Sung, C., Lu, T., Wang, C., Chou, E.H., Ko, C., Huang, C., et al. (2022) In-hospital Cardiac Arrest in United States Emergency Departments, 2010-2018. Frontiers in Cardiovascular Medicine, 9, Article 874461. [Google Scholar] [CrossRef] [PubMed]
[9] Yang, J. (2023) Percentage of Persons in the U.S. with One or More Hospital Stays in the Past Year from 1997 to 2019, by Gender.
https://www.statista.com/statistics/185109/persons-with-hospital-stays-inthe-past-year-by-gender-since-1997/
[10] Korhonen, V. (2024) Resident Population of the United States by Sex and Age as of July 1, 2023.
https://www.statista.com/statistics/241488/population-of-the-us-by-sex-and-age/
[11] Ashraf, M., Sulaiman, S., Alyami, B., Bhatia, A. and Jahangir, A. (2023) Seasonal Variation in the Incidence of In-Hospital Cardiac Arrest. JACC: Clinical Electrophysiology, 9, 1755-1767. [Google Scholar] [CrossRef] [PubMed]
[12] Acharya, P., Ranka, S., Sethi, P., Bharati, R., Hu, J., Noheria, A., et al. (2021) Incidence, Predictors, and Outcomes of In‐hospital Cardiac Arrest in COVID‐19 Patients Admitted to Intensive and Non‐Intensive Care Units: Insights from the AHA COVID‐19 CVD Registry. Journal of the American Heart Association, 10, e021204. [Google Scholar] [CrossRef] [PubMed]
[13] Khan, M.Z., Syed, M., Agrawal, P., Osman, M., Khan, M.U., Alharbi, A., et al. (2021) Baseline Characteristics and Outcomes of End-Stage Renal Disease Patients after In-Hospital Sudden Cardiac Arrest: A National Perspective. Journal of Interventional Cardiac Electrophysiology, 63, 503-512. [Google Scholar] [CrossRef] [PubMed]
[14] Ohlsson, M.A., Kennedy, L.M.A., Juhlin, T. and Melander, O. (2020) Risk Prediction of Future Cardiac Arrest by Evaluation of a Genetic Risk Score Alone and in Combination with Traditional Risk Factors. Resuscitation, 146, 74-79. [Google Scholar] [CrossRef] [PubMed]
[15] 李永凯, 李转运, 何小静, 等. 院内急诊抢救室心脏骤停风险预测模型构建及验证[J]. 中华急诊医学杂志, 2024, 33(1): 20-27.
[16] 梁立丰, 张文娟. 预测重症患者院内心脏骤停列线图的建立与验证[J]. 中华急诊医学杂志, 2023, 32(1): 38-45.
[17] Mir, T., Qureshi, W.T., Uddin, M., Shafi, O., Sheikh, M. and Kakouros, N. (2022) Non-ST Elevation Myocardial Infarction and Cardiac Arrest: The United States Nationwide Emergency Department Sample. Journal of Cardiology, 79, 98-104. [Google Scholar] [CrossRef] [PubMed]
[18] Albert, M., Herlitz, J., Rawshani, A., Forsberg, S., Ringh, M., Hollenberg, J., et al. (2023) Aetiology and Outcome in Hospitalized Cardiac Arrest Patients. European Heart Journal Open, 3, oead066. [Google Scholar] [CrossRef] [PubMed]
[19] Simiera, M., Miśkowiec, D., Mrozowska-Peruga, E., Nowakowska, M., Kłosińska, M. and Kasprzak, J.D. (2022) Improved Outcomes in Survivors of Cardiac Arrest Qualified for Early Coronary Angiography: A Single Tertiary Center Study. Kardiologia Polska, 80, 1112-1118. [Google Scholar] [CrossRef] [PubMed]
[20] Gong, W., Yan, Y., Wang, X., Zheng, W., Smith, S.C., Fonarow, G.C., et al. (2022) Risk Factors for In-Hospital Cardiac Arrest in Patients with ST-Segment Elevation Myocardial Infarction. Journal of the American College of Cardiology, 80, 1788-1798. [Google Scholar] [CrossRef] [PubMed]
[21] Kim, Y.G., Roh, S.Y., Han, K., Jeong, J.H., Choi, Y.Y., Min, K., et al. (2022) Hypertension and Diabetes Including Their Earlier Stage Are Associated with Increased Risk of Sudden Cardiac Arrest. Scientific Reports, 12, Article No. 12307. [Google Scholar] [CrossRef] [PubMed]
[22] Abuelgasim, E., Shah, S., Abuelgasim, B., Soni, N., Thomas, A., Elgasim, M., et al. (2021) Clinical Overview of Diabetes Mellitus as a Risk Factor for Cardiovascular Death. Reviews in Cardiovascular Medicine, 22, 301-304. [Google Scholar] [CrossRef] [PubMed]
[23] Lippi, G., Sanchis-Gomar, F. and Cervellin, G. (2020) Global Epidemiology of Atrial Fibrillation: An Increasing Epidemic and Public Health Challenge. International Journal of Stroke, 16, 217-221. [Google Scholar] [CrossRef] [PubMed]
[24] Waldmann, V., Jouven, X., Narayanan, K., Piot, O., Chugh, S.S., Albert, C.M., et al. (2020) Association between Atrial Fibrillation and Sudden Cardiac Death: Patho-Physiological and Epidemiological Insights. Circulation Research, 127, 301-309. [Google Scholar] [CrossRef] [PubMed]
[25] Ryden, A., Engdahl, J., Claesson, A., Nordberg, P., Ringh, M., Hollenberg, J., et al. (2018) Is Atrial Fibrillation a Risk Factor for In-Hospital Cardiac Arrest? A Swedish Retrospective Cohort Study. BMJ Open, 8, e022092. [Google Scholar] [CrossRef] [PubMed]
[26] 华畅, 蒋超, 何柳, 等. 心房颤动患者抗凝治疗的死亡原因及危险因素分析[J]. 中华心血管病杂志, 2021, 49(4): 353-359.
[27] Valembois, L., Audureau, E., Takeda, A., Jarzebowski, W., Belmin, J. and Lafuente-Lafuente, C. (2019) Antiarrhythmics for Maintaining Sinus Rhythm after Cardioversion of Atrial Fibrillation. Cochrane Database of Systematic Reviews, 9, CD005049. [Google Scholar] [CrossRef] [PubMed]
[28] Amon, J., Wong, G.C., Lee, T., Singer, J., Cairns, J., Shavadia, J.S., et al. (2022) Incidence and Predictors of Adverse Events among Initially Stable ST‐Elevation Myocardial Infarction Patients Following Primary Percutaneous Coronary Intervention. Journal of the American Heart Association, 11, e025572. [Google Scholar] [CrossRef] [PubMed]
[29] Reinier, K., Moon, J., Chugh, H.S., Sargsyan, A., Nakamura, K., Norby, F.L., et al. (2023) Risk Factors for Sudden Cardiac Arrest among Hispanic or Latino Adults in Southern California: Ventura PRESTO and HCHS/SOL. Journal of the American Heart Association, 12, e030062. [Google Scholar] [CrossRef] [PubMed]
[30] Jung, E., Park, J.H., Ro, Y.S., Ryu, H.H., Cha, K., Do Shin, S., et al. (2023) Family History, Socioeconomic Factors, Comorbidities, Health Behaviors, and the Risk of Sudden Cardiac Arrest. Scientific Reports, 13, Article No. 21341. [Google Scholar] [CrossRef] [PubMed]
[31] Docherty, K.F., Ferreira, J.P., Sharma, A., Girerd, N., Gregson, J., Duarte, K., et al. (2020) Predictors of Sudden Cardiac Death in High‐Risk Patients Following a Myocardial Infarction. European Journal of Heart Failure, 22, 848-855. [Google Scholar] [CrossRef] [PubMed]
[32] Song, S., Lee, H.A., Kim, Y., Jeon, B.K., Moon, C.M. and Park, J. (2023) Dynamic Changing Smoking Habits and Cardiovascular Events in Patients Newly Diagnosed with Hypertension, Diabetes, or Dyslipidemia: A National Cohort Study. Frontiers in Cardiovascular Medicine, 10, Article 1190227. [Google Scholar] [CrossRef] [PubMed]
[33] Wu, A.D., Lindson, N., Hartmann-Boyce, J., Wahedi, A., Hajizadeh, A., Theodoulou, A., et al. (2022) Smoking Cessation for Secondary Prevention of Cardiovascular Disease. Cochrane Database of Systematic Reviews, 8, CD014936. [Google Scholar] [CrossRef] [PubMed]
[34] Høybye, M., Stankovic, N., Lauridsen, K.G., Holmberg, M.J., Andersen, L.W. and Granfeldt, A. (2021) Pulseless Electrical Activity vs. Asystole in Adult In-Hospital Cardiac Arrest: Predictors and Outcomes. Resuscitation, 165, 50-57. [Google Scholar] [CrossRef] [PubMed]
[35] Wang, C., Chang, W., Huang, C., Tsai, M., Lu, T., Chou, E., et al. (2020) Associations between Central Obesity and Outcomes of Adult In-Hospital Cardiac Arrest: A Retrospective Cohort Study. Scientific Reports, 10, Article No. 4604. [Google Scholar] [CrossRef] [PubMed]
[36] Jeong, J.H., Kim, Y.G., Han, K., Roh, S., Lee, H.S., Choi, Y.Y., et al. (2024) Association of Temporal Change in Body Mass Index with Sudden Cardiac Arrest in Diabetes Mellitus. Cardiovascular Diabetology, 23, Article No. 46. [Google Scholar] [CrossRef] [PubMed]
[37] Stankovic, N., Holmberg, M.J., Granfeldt, A. and Andersen, L.W. (2022) Socioeconomic Status and Risk of In-Hospital Cardiac Arrest. Resuscitation, 177, 69-77. [Google Scholar] [CrossRef] [PubMed]
[38] Gonuguntla, K., Chobufo, M.D., Shaik, A., Patel, N., Penmetsa, M., Sattar, Y., et al. (2024) Impact of Social Vulnerability on Cardiac Arrest Mortality in the United States, 2016 to 2020. Journal of the American Heart Association, 13, e033411. [Google Scholar] [CrossRef] [PubMed]
[39] Delisle, B.P., George Jr., A.L., Nerbonne, J.M., et al. (2021) Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report from the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical Considerations. Circulation: Arrhythmia and Electrophysiology, 14, e010190.
[40] Tsai, C., Lu, T., Fang, C., Wang, C., Lin, J., Chen, W., et al. (2022) Development and Validation of a Novel Triage Tool for Predicting Cardiac Arrest in the Emergency Department. Western Journal of Emergency Medicine, 23, 258-267. [Google Scholar] [CrossRef] [PubMed]
[41] Kim, J., Seo, D.W., Kim, Y., Jeong, J., Kang, H., Han, K.S., et al. (2020) Prolonged Length of Stay in the Emergency Department and Increased Risk of In-Hospital Cardiac Arrest: A Nationwide Population-Based Study in South Korea, 2016-2017. Journal of Clinical Medicine, 9, Article 2284. [Google Scholar] [CrossRef] [PubMed]
[42] Kim, J., Bae, H., Sohn, C.H., Cho, S., Hwang, J., Kim, W.Y., et al. (2020) Maximum Emergency Department Overcrowding Is Correlated with Occurrence of Unexpected Cardiac Arrest. Critical Care, 24, Article No. 305. [Google Scholar] [CrossRef] [PubMed]