血钙标准分数对女性轻度肾动脉狭窄的预测价值

Predictive Value of Standard Score of Serum Calcium in Mild Renal Artery Stenosis in Women

摘要: 目的：探讨女性轻度肾动脉狭窄患者的预测因素，帮助临床医生及早发现疾病并干预疾病进展。方法：选择2019年01月至2024年12月间在华东医院肾内科收治的行肾动脉MRA检查的92例女性患者作为研究对象，根据有无肾动脉狭窄分为轻度狭窄组(n = 52)与非狭窄组(n = 40)，比较了两组患者的人口学特征、临床特征及实验室参数。采用Logistic回归分析确定轻度肾动脉狭窄的独立风险因子，通过构建受试者工作特征(Receiver operation characteristics, ROC)曲线评估不同变量对轻度肾动脉狭窄的预测价值。结果：在这项横断面研究中，二元多因素Logistic回归分析显示，年龄(OR = 1.088, P = 0.002)、血红蛋白(OR = 0.946, P = 0.002)、血钙标准分数(OR = 3.248, P = 0.004)是女性患者发生低级别RAS的独立危险因素。ROC曲线分析提示，血钙曲线下面积(area under the curve, AUC)为0.706。对轻度肾动脉狭窄有一定的预测价值。结论：血钙是肾动脉狭窄发生、发展的危险因素，可用作筛选该病高危患者的指标。

Abstract: Objective: To investigate the predictive factors for female patients with mild renal artery stenosis, assisting clinicians in early detection and intervention of the disease progression. Methods: We selected 92 female patients who underwent renal artery MRA examination at the Huadong Hospital from January 2019 to December 2024 as the research subjects and divided them into two groups based on the presence or absence of renal artery stenosis: mild stenosis group (n = 52) and non-stenosis group (n = 40). We compared the demographic, clinical, and laboratory parameters between the two groups. We used Logistic regression analysis to determine the independent risk factors for mild renal artery stenosis, and constructed a receiver operating characteristic (ROC) curve to evaluate the predictive value of different variables for mild renal artery stenosis. Results: In this cross-sectional study, Binary Logistic Regression Model showed that age (OR = 1.088, P = 0.002), hemoglobin (OR = 0.946, P = 0.002), and standard score of serum calcium (OR = 3.248, P = 0.004) were the independent risk factors for the development of low-grade RAS in women. ROC curve analysis showed that the area under the curve (AUC) was 0.706, which had a certain predictive value for mild renal artery stenosis. Conclusion: Serum calcium levels are a risk factor for the development and progression of renal artery stenosis and can be used as an indicator to screen patients at risk for this disease.