有氧运动时长对2型糖尿病患者炎症因子的影响

The Effect of Aerobic Exercise Duration on Inflammatory Factors in Patients with Type 2 Diabetes Mellitus

摘要: 2型糖尿病与炎症因子密切相关，CRP、TNF-α和IL-6等炎症因子通过多种途径影响胰岛素敏感性和β细胞功能，导致糖尿病发生发展。本研究探讨有氧运动时长对2型糖尿病患者炎症因子的影响，有氧运动通过直接抗炎作用和间接抗炎效应改善炎症状态。其中，短期有氧运动(8~12周)可快速调控炎症因子，但部分效应可逆；长期有氧运动(≥6个月)则具有累积性和可持续性抗炎效果，能重构脂肪组织、重塑免疫细胞稳态、改善胰岛素信号通路并保护心血管系统。研究结果表明，优化有氧运动时长可有效降低2型糖尿病患者的炎症水平，改善代谢状况。

Abstract: Type 2 diabetes is closely related to inflammatory factors. Inflammatory factors such as CRP, TNF-α and IL-6 affect insulin sensitivity and β cell function in many ways, leading to the development of diabetes. This study discusses the influence of aerobic exercise duration on inflammatory factors in patients with type 2 diabetes mellitus. Aerobic exercise can improve the inflammatory state through direct and indirect anti-inflammatory effects. Among them, short-term aerobic exercise (8~12 weeks) can quickly regulate inflammatory factors, but some effects are reversible; Long-term aerobic exercise (≥6 months) has cumulative and sustainable anti-inflammatory effects, which can reconstruct adipose tissue, reshape immune cell homeostasis, improve insulin signaling pathway and protect cardiovascular system. The results show that optimizing the duration of aerobic exercise can effectively reduce the inflammation level and improve the metabolic status of patients with type 2 diabetes.