Notch1在恶性肿瘤发展中的研究进展
The Research Progress on Notch1 in the Development of Malignant Tumors
DOI: 10.12677/acm.2025.1551573, PDF,   
作者: 安 昕*:甘肃中医药大学第一临床医学院,甘肃 兰州;刘 华#:甘肃省人民医院呼吸与危重症医学科,甘肃 兰州
关键词: Notch1恶性肿瘤发展综述Notch1 Malignant Tumors Development Review
摘要: Notch1属于Notch信号通路的重要蛋白受体,是一种配体激活的转录因子。Notch1作为一种转录因子,通过调控细胞增殖、迁移、侵袭、上皮–间充质转化、肿瘤干细胞特性、免疫逃逸等细胞活动参与多种恶性肿瘤的进展。本文就Notch1在常见恶性肿瘤发展中的相关研究进展进行综述,旨在为肿瘤的诊疗提供新的思路。
Abstract: Notch1 is an important receptor protein in the Notch signaling pathway and a ligand-activated transcription factor. As a transcription factor, Notch1 participates in the progression of various malignant tumors by regulating cellular activities such as cell proliferation, migration, invasion, epithelial-mesenchymal transition, tumor stem cell characteristics, and immune evasion. This review summarizes the research progress of Notch1 in the development of common malignant tumors, aiming to provide new insights for tumor diagnosis and therapy.
文章引用:安昕, 刘华. Notch1在恶性肿瘤发展中的研究进展[J]. 临床医学进展, 2025, 15(5): 1901-1908. https://doi.org/10.12677/acm.2025.1551573

参考文献

[1] Ellisen, L.W., Bird, J., West, D.C., Soreng, A.L., Reynolds, T.C., Smith, S.D., et al. (1991) TAN-1, the Human Homolog of the Drosophila Notch Gene, Is Broken by Chromosomal Translocations in T Lymphoblastic Neoplasms. Cell, 66, 649-661. [Google Scholar] [CrossRef] [PubMed]
[2] Artavanis-Tsakonas, S., Rand, M.D. and Lake, R.J. (1999) Notch Signaling: Cell Fate Control and Signal Integration in Development. Science, 284, 770-776. [Google Scholar] [CrossRef] [PubMed]
[3] Lin, J., Xu, Z., Xie, J., Deng, X., Jiang, L., Chen, H., et al. (2021) Oncogene APOL1 Promotes Proliferation and Inhibits Apoptosis via Activating NOTCH1 Signaling Pathway in Pancreatic Cancer. Cell Death & Disease, 12, Article No. 760. [Google Scholar] [CrossRef] [PubMed]
[4] Liu, W., Zhang, J., Gan, X., Shen, F., Yang, X., Du, N., et al. (2018) LGR5 Promotes Epithelial Ovarian Cancer Proliferation, Metastasis, and Epithelial-Mesenchymal Transition through the Notch1 Signaling Pathway. Cancer Medicine, 7, 3132-3142. [Google Scholar] [CrossRef] [PubMed]
[5] Zhong, Y., Shen, S., Zhou, Y., Mao, F., Lin, Y., Guan, J., et al. (2016) NOTCH1 Is a Poor Prognostic Factor for Breast Cancer and Is Associated with Breast Cancer Stem Cells. OncoTargets and Therapy, 9, 6865-6871. [Google Scholar] [CrossRef] [PubMed]
[6] Rice, M.A., Hsu, E., Aslan, M., Ghoochani, A., Su, A. and Stoyanova, T. (2019) Loss of Notch1 Activity Inhibits Prostate Cancer Growth and Metastasis and Sensitizes Prostate Cancer Cells to Antiandrogen Therapies. Molecular Cancer Therapeutics, 18, 1230-1242. [Google Scholar] [CrossRef] [PubMed]
[7] Zhou, K., Guo, S., Li, F., Sun, Q. and Liang, G. (2020) Exosomal PD-L1: New Insights into Tumor Immune Escape Mechanisms and Therapeutic Strategies. Frontiers in Cell and Developmental Biology, 8, Article 569219. [Google Scholar] [CrossRef] [PubMed]
[8] Sinicropi-Yao, S.L., Amann, J.M., Lopez, D.L.Y., Cerciello, F., Coombes, K.R. and Carbone, D.P. (2019) Co-Expression Analysis Reveals Mechanisms Underlying the Varied Roles of NOTCH1 in NSCLC. Journal of Thoracic Oncology, 14, 223-236. [Google Scholar] [CrossRef] [PubMed]
[9] Mariscal, J., Alonso-Nocelo, M., Muinelo-Romay, L., Barbazan, J., Vieito, M., Abalo, A., et al. (2016) Molecular Profiling of Circulating Tumour Cells Identifies Notch1 as a Principal Regulator in Advanced Non-Small Cell Lung Cancer. Scientific Reports, 6, Article No. 37820. [Google Scholar] [CrossRef] [PubMed]
[10] Liu, Y., Li, Q., Geng, L., Zhou, X., Zhou, X., Dong, Y., et al. (2022) Siah1 Promotes the Proliferation of NSCLC Cells through Ubiquitinating and Stabilizing Notch1. Experimental Cell Research, 419, Article ID: 113305. [Google Scholar] [CrossRef] [PubMed]
[11] Huang, D., Wang, S., Wang, A., Chen, X. and Zhang, H. (2016) Thymosin β 4 Silencing Suppresses Proliferation and Invasion of Non-Small Cell Lung Cancer Cells by Repressing Notch1 Activation. Acta Biochimica et Biophysica Sinica, 48, 788-794. [Google Scholar] [CrossRef] [PubMed]
[12] Hany, H., Shalaby, A., Al Kashef, W., Kandil, W., Shahin, R., El-Alfy, H., et al. (2018) Evaluation of the Role of Notch1 Expression in Hepatic Carcinogenesis with Clinico-Pathological Correlation. Pathology, 50, 730-736. [Google Scholar] [CrossRef] [PubMed]
[13] Sui, C., Zhuang, C., Sun, D., Yang, L., Zhang, L. and Song, L. (2017) Notch1 Regulates the JNK Signaling Pathway and Increases Apoptosis in Hepatocellular Carcinoma. Oncotarget, 8, 45837-45847. [Google Scholar] [CrossRef] [PubMed]
[14] Huang, W., Liao, W. and Sun, R. (2016) Astragalus Polysaccharide Induces the Apoptosis of Human Hepatocellular Carcinoma Cells by Decreasing the Expression of Notch1. International Journal of Molecular Medicine, 38, 551-557. [Google Scholar] [CrossRef] [PubMed]
[15] Wu, Q., Ren, X., Chen, Y., Jin, Y., Zhan, X., Liu, C., et al. (2022) KIF2A Participates in the Progression of Hepatocellular Carcinoma and Angiogenesis by Interacting with Notch1. Experimental and Therapeutic Medicine, 24, Article No. 683. [Google Scholar] [CrossRef] [PubMed]
[16] Li, G., Zhou, Z., Zhou, H., Zhao, L., Chen, D., Chen, H., et al. (2017) The Expression Profile and Clinicopathological Significance of Notch1 in Patients with Colorectal Cancer: A Meta-Analysis. Future Oncology, 13, 2103-2118. [Google Scholar] [CrossRef] [PubMed]
[17] Wang, J., Sun, M., Ma, R., et al. (2022) Down-Regulation of NOTCH1 and PKM2 Can Inhibit the Growth and Metastasis of Colorectal Cancer Cells. American Journal of Translational Research, 14, 5455-5465.
[18] Liao, W., Li, G., You, Y., Wan, H., Wu, Q., Wang, C., et al. (2017) Antitumor Activity of Notch-1 Inhibition in Human Colorectal Carcinoma Cells. Oncology Reports, 39, 1063-1071. [Google Scholar] [CrossRef] [PubMed]
[19] Huang, B., Jin, G., Qu, C., Ma, H., Ding, C., Zhang, Y., et al. (2019) Elevated Expression of NOTCH1 Associates with Lymph Node Metastasis of Gastric Cancer and Knock-Down of NOTCH1 Attenuates Tumor Cell Progression. Medical Science Monitor, 25, 9939-9948. [Google Scholar] [CrossRef] [PubMed]
[20] Wang, L., Wang, W.Y. and Cao, L.P. (2015) SIRT3 Inhibits Cell Proliferation in Human Gastric Cancer through Down-Regulation of Notch-1. International Journal of Clinical and Experimental Medicine, 8, 5263-5271.
[21] Zhang, H., Wang, X., Xu, J. and Sun, Y. (2014) Notch1 Activation Is a Poor Prognostic Factor in Patients with Gastric Cancer. British Journal of Cancer, 110, 2283-2290. [Google Scholar] [CrossRef] [PubMed]
[22] Rui, X., Zhao, H., Xiao, X., Wang, L., Mo, L. and Yao, Y. (2018) MicroRNA-34a Suppresses Breast Cancer Cell Proliferation and Invasion by Targeting Notch1. Experimental and Therapeutic Medicine, 16, 4387-4392. [Google Scholar] [CrossRef] [PubMed]
[23] Paryan, M., Tavakoli, R., Rad, S.M.A.H., Feizi, N., Kamani, F., Mostafavi, E., et al. (2016) Over-Expression of NOTCH1 as a Biomarker for Invasive Breast Ductal Carcinoma. 3 Biotech, 6, Article No. 58. [Google Scholar] [CrossRef] [PubMed]
[24] Saran, U., Chandrasekaran, B., Tyagi, A., Shukla, V., Singh, A., Sharma, A.K., et al. (2023) A Small Molecule Inhibitor of Notch1 Modulates Stemness and Suppresses Breast Cancer Cell Growth. Frontiers in Pharmacology, 14, Article 1150774. [Google Scholar] [CrossRef] [PubMed]
[25] Liang, T., Guo, Q., Li, L., Cheng, Y., Ren, C. and Zhang, G. (2016) MicroRNA-433 Inhibits Migration and Invasion of Ovarian Cancer Cells via Targeting Notch1. Neoplasma, 63, 696-704. [Google Scholar] [CrossRef] [PubMed]
[26] Ginnavaram, V., Vasugi, A. and Sundaram, S. (2023) Immunohistochemical Evaluation of Notch1 in Ovarian Tumours and Its Prognostic Implications. Cureus, 15, e40830. [Google Scholar] [CrossRef] [PubMed]
[27] Alniaimi, A.N., Demorest-Hayes, K., Alexander, V.M., Seo, S., Yang, D. and Rose, S. (2015) Increased Notch1 Expression Is Associated with Pooroverall Survival in Patients Withovarian Cancer. International Journal of Gynecological Cancer, 25, 208-213. [Google Scholar] [CrossRef] [PubMed]
[28] Qian, X., Tang, S., Shen, Y., Chen, L., Cheng, X. and Wan, X. (2020) Notch1 Affects Chemo-Resistance through Regulating Epithelial-Mesenchymal Transition (EMT) in Epithelial Ovarian Cancer Cells. International Journal of Medical Sciences, 17, 1215-1223. [Google Scholar] [CrossRef] [PubMed]
[29] Sun, Y., Zhang, R., Zhou, S. and Ji, Y. (2015) Overexpression of Notch1 Is Associated with the Progression of Cervical Cancer. Oncology Letters, 9, 2750-2756. [Google Scholar] [CrossRef] [PubMed]
[30] Yang, X., Ni, W. and Lei, K. (2013) miR-200b Suppresses Cell Growth, Migration and Invasion by Targeting Notch1 in Nasopharyngeal Carcinoma. Cellular Physiology and Biochemistry, 32, 1288-1298. [Google Scholar] [CrossRef] [PubMed]
[31] Gallo, C., Fragliasso, V., Donati, B., Torricelli, F., Tameni, A., Piana, S., et al. (2018) The bHLH Transcription Factor DEC1 Promotes Thyroid Cancer Aggressiveness by the Interplay with Notch1. Cell Death & Disease, 9, Article No. 871. [Google Scholar] [CrossRef] [PubMed]
[32] Cheng, H., Zhu, H., Cao, M., Lu, C., Bao, S. and Pan, Y. (2019) HtrA1 Suppresses the Growth of Pancreatic Cancer Cells by Modulating Notch-1 Expression. Brazilian Journal of Medical and Biological Research, 52, e7718. [Google Scholar] [CrossRef] [PubMed]