SARS-CoV-2感染降低精子质量的机制研究进展
Research Advances in the Mechanisms Underlying SARS-CoV-2-Induced Decline in Sperm Quality
DOI: 10.12677/jcpm.2025.43316, PDF,   
作者: 邓 航, 张培海：成都中医药大学附属医院泌尿外科，四川 成都
关键词: SARS-CoV-2；精子质量；不育；SARS-CoV-2； Sperm Quality； Infertility
摘要: SARS-CoV-2是一种新型冠状病毒，其主要通过血管紧张素转换酶2 (ACE2)入侵靶点细胞，可导致感染者出现呼吸系统、神经系统、心血管系统以及生殖系统症状。本文通过总结SARS-CoV-2降低精子质量的相关机制，发现SARS-CoV-2主要通过睾丸炎症反应、氧化应激反应、下丘脑-垂体-性腺轴，睾丸微循环障碍等途径影响精子的发生和成熟，从而导致男性精子质量下降。
Abstract: SARS-CoV-2, a novel coronavirus, primarily invades host cells via the angiotensin-converting enzyme 2 (ACE2) receptor and can induce symptoms affecting the respiratory, nervous, cardiovascular, and reproductive systems in infected individuals. This article synthesizes current research on the mechanisms by which SARS-CoV-2 reduces sperm quality, revealing that the virus primarily impairs spermatogenesis and sperm maturation through testicular inflammatory responses, oxidative stress responses, dysregulation of the hypothalamic-pituitary-gonadal (HPG) axis, and testicular microcirculatory disturbances, ultimately leading to diminished sperm quality.
文章引用：邓航, 张培海. SARS-CoV-2感染降低精子质量的机制研究进展[J]. 临床个性化医学, 2025, 4(3): 60-66. https://doi.org/10.12677/jcpm.2025.43316

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