血清白蛋白水平与脑出血患者的颅内动脉粥样硬化的相关性研究

Correlation Analysis between Serum Albumin Levels and Intracranial Atherosclerosis in Patients with Intracerebral Hemorrhage

摘要: 目的：探讨血清白蛋白水平在急性脑出血患者中与颅内动脉粥样硬化严重程度及其独立危险因素的相关性。方法：回顾性收集2022年8月至2024年9月就诊于安徽医科大学第二附属医院卒中中心患者的临床资料。将白蛋白分为三等分组，采用单因素分析临床资料与不同水平的白蛋白、血肿体积的相关性；以动脉狭窄50%为界限，将患者分为严重狭窄组和非严重狭窄组，使用多因素Logistic回归分析，进一步探讨影响颅内动脉粥样硬化严重程度的因素。结果：1. 对白蛋白的三等分组进行单因素分析，tertiles 3组(血清白蛋白水平最高)其年龄、入院收缩压和舒张压较另外两组低，血红蛋白和白细胞数较另外两组高，以上之间的差异具有统计学意义(P < 0.05)。2. 严重狭窄组与非严重狭窄组相比，白蛋白水平高于非严重狭窄组，差异具有统计学意义(P < 0.05)，但血肿体积在两组之间的差异没有统计学意义；多因素Logistic回归分析提示白蛋白是动脉粥样硬化严重程度的独立危险因素。结论：1. 在脑出血患者中，血清白蛋白水平与年龄大小、血压高低呈负相关，与血红蛋白、白细胞数呈正相关；2. 年龄、入院收缩压与动脉粥样硬化严重程度呈正相关，而白蛋白与动脉粥样硬化严重程度呈负相关，年龄、白蛋白、收缩压是预测动脉粥样硬化严重程度的独立危险因素。3. 血肿体积与动脉粥样硬化严重程度无统计学关系。

Abstract: Objective: To investigate the correlation between serum albumin levels with the severity of intracranial atherosclerosis in patients with acute cerebral hemorrhage. Methods: The clinical data of patients who visited the Second Affiliated Hospital of Anhui Medical University from August 2022 to September 2024 were retrospectively collected. Albumin was divided into three groups each, and univariate analysis was performed on all clinical data of the patients to statistically analyze the correlation between different levels of albumin and hematoma volume; based on a stenosis threshold of 50%, patients were divided into severe stenosis group and non-severe stenosis group. Multivariate Logistic regression analysis further explored factors affecting the severity of atherosclerosis. Results: 1. A univariate analysis was conducted on the tertiles of serum albumin levels. The tertiles 3 group (with the highest serum albumin levels) had significantly lower age, admission systolic and diastolic blood pressures, but higher hemoglobin and white blood cell counts compared with the other two groups (P < 0.05). 2. Compared with the non-severe stenosis group, the severe stenosis group had higher serum albumin levels, with a statistically significant difference (P < 0.05). However, no statistically significant difference was found in hematoma volume between the two groups. Multivariate logistic regression analysis indicated that serum albumin is an independent risk factor for the severity of atherosclerosis. Conclusion: 1. among patients with intracerebral hemorrhage, serum albumin levels are negatively correlated with age and blood pressure but positively correlated with hemoglobin and white blood cell count; 2. Age and admission systolic blood pressure are positively correlated with the severity of atherosclerosis, whereas serum albumin is negatively correlated with it. Importantly, age, serum albumin, and systolic blood pressure have been identified as independent risk factors for predicting the severity of atherosclerosis. 3. No statistically significant relationship was found between hematoma volume and the severity of atherosclerosis.