一例通过mNGS揭示潜伏期可能达八年的内脏利什曼病
A Case of Visceral Leishmaniasis with Possible Eight-Year Incubation Period Revealed by Metagenomic Next-Generation Sequencing
DOI: 10.12677/acm.2025.1561697, PDF,   
作者: 田仕君, 杜 阳, 贾 蓓*：重庆医科大学附属第一医院感染科，重庆；夏 红：重庆市大足区人民医院感染科，重庆
关键词: 内脏利什曼病；八年潜伏期；宏基因组下一代测序；Visceral Leishmaniasis； Eight-Year Incubation Period； Metagenomic Next-Generation Sequencing (mNGS)
摘要: 一名51岁、无基础病患者，因发热2月伴白细胞减少和肝功能异常入院，3次骨髓检查未发现病原体，最终通过血液宏基因组测序技术(mNGS)检测到杜氏利什曼原虫和婴儿利什曼原虫。该患者八年前曾在尼日利亚生活。入院后给予两性霉素B脱氧胆酸盐治疗11天后体温正常，疗程35天两性霉素B脱氧胆酸盐总剂量为1077 mg，尽管在治疗期间出现了心脏轻度增大、持续性白细胞减少、贫血和肌酐升高等不良反应，但他仍顺利完成了治疗，随访9月无复发。
Abstract: A fifty-one-year-old immunocompetent man presented with two-month fever, accompanied by leucopenia and abnormal liver biochemical parameters. Three bone marrow exams did not find parasites and eventually metagenomic next-generation sequencing (mNGS) on blood specimen revealed both Leishmania donovani and Leishmania infantum. He had been working in Nigeria eight years before. His temperature returned to normal after receiving an eleven-day of amphotericin B deoxycholate infusion, and treatment lasting for thirty-five days with a total dosage of 1077 mg. Although he had a cardiomegaly, persistently leucopenia, anemia, creatinine enhancement during treatment, he completed the course with a favorable outcome.
文章引用：田仕君, 夏红, 杜阳, 贾蓓. 一例通过mNGS揭示潜伏期可能达八年的内脏利什曼病[J]. 临床医学进展, 2025, 15(6): 52-56. https://doi.org/10.12677/acm.2025.1561697

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