胶质瘤血管新生细胞起源研究进展

Research Progress on the Cellular Origin of Angiogenesis in Glioma

摘要: 胶质瘤是一种具有高度侵袭性和致命性的脑肿瘤，其生长与血管新生密切相关。近年来，研究者们逐渐认识到血管新生细胞的起源对胶质瘤的进展和治疗具有重要意义。当前的研究表明，胶质瘤中的血管新生不仅涉及肿瘤细胞本身的表型变化，还与多种细胞类型的相互作用密切相关，包括内皮细胞、肿瘤相关巨噬细胞和间质细胞等。这些细胞在血管生成过程中发挥着不同的功能，其来源及其微环境对血管新生的调控机制也逐渐被揭示。然而，尽管当前研究已取得了一定的进展，但仍存在对不同细胞起源和调节机制的理解不足、研究模型的局限性及临床转化的挑战等问题。本文旨在综述胶质瘤中血管新生的机制，探讨不同细胞类型在血管新生中的作用及其起源，分析最新的研究成果和理论框架，为胶质瘤的治疗提供新的思路和方向。

Abstract: Glioma is a highly invasive and fatal brain tumor whose growth is closely associated with angiogenesis. In recent years, researchers have increasingly recognized the significance of the cellular origin of angiogenesis in glioma progression and treatment. Current studies indicate that angiogenesis in glioma involves not only phenotypic changes in tumor cells themselves but also interactions with multiple cell types, including endothelial cells, tumor-associated macrophages, and stromal cells. These cells play distinct roles in the vascularization process, and their origins, along with the regulatory mechanisms of the tumor microenvironment on angiogenesis, are gradually being elucidated. However, despite progress in current research, challenges remain, such as insufficient understanding of different cellular origins and regulatory mechanisms, limitations in research models, and difficulties in clinical translation. This article aims to review the mechanisms of angiogenesis in glioma, explore the roles and origins of different cell types in this process, analyze recent research findings and theoretical frameworks, and provide novel insights and directions for glioma therapy.