长链非编码RNA HOTAIR在肝细胞癌中的分子机制及临床应用研究进展
Research Advances on the Molecular Mechanisms and Clinical Applications of Long Non-Coding RNA HOTAIR in Hepatocellular Carcinoma
DOI: 10.12677/jcpm.2025.43344, PDF,   
作者: 李长虹：济宁医学院临床医学院(附属医院)，山东 济宁；刘 涛*：济宁医学院附属医院肝胆外科，山东 济宁
关键词: HOTAIR；肝癌；肿瘤标记物；LncRNA；靶向治疗；HOTAIR； Hepatocellular Carcinoma； Molecular Biomarker； LncRNA； Targeted Therapy
摘要: 长链非编码RNA HOX转录反义RNA (HOTAIR)能够从多种机制参与肝癌的生物学进程，导致肝癌患者预后不良。研究发现，HOTAIR在肝癌细胞中表达量增高，其表达水平与肝癌的肿瘤分期密切相关，可能是肝癌早期诊断的肿瘤分子标记物。另外，敲低HOTAIR可以从多种途径抑制肝癌细胞的侵袭和转移，调控HOTAIR的表达可能是肝癌靶向治疗的新思路。本文系统综述了HOTAIR在HCC发生发展中的分子机制及其作为新型生物标志物和治疗靶点的潜力，为HCC的精准诊疗提供了理论依据和转化方向。
Abstract: The long non-coding RNA HOX transcript antisense RNA (HOTAIR) participates in the biological processes of hepatocellular carcinoma (HCC) through multiple mechanisms, leading to poor prognosis in patients. Studies have found that HOTAIR is upregulated in HCC cells, and its expression level is closely associated with tumor stage, suggesting its potential as a molecular biomarker for early HCC diagnosis. Moreover, knockdown of HOTAIR can inhibit HCC cell invasion and metastasis through various pathways, indicating that modulating HOTAIR expression may represent a novel therapeutic strategy for HCC. This review systematically summarizes the molecular mechanisms of HOTAIR in HCC progression and its potential as a new biomarker and therapeutic target, providing a theoretical foundation and translational direction for the precise diagnosis and treatment of HCC.
文章引用：李长虹, 刘涛. 长链非编码RNA HOTAIR在肝细胞癌中的分子机制及临床应用研究进展[J]. 临床个性化医学, 2025, 4(3): 281-287. https://doi.org/10.12677/jcpm.2025.43344

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