外泌体在肺腺癌中的发生、诊断及治疗的作用和研究进展
The Role and Research Progress of Exosomes in the Pathogenesis, Diagnosis and Treatment of Lung Adenocarcinoma
DOI: 10.12677/jcpm.2025.43348, PDF,    科研立项经费支持
作者: 王星昊, 刘兆云：延安大学医学院，陕西 延安；李建英*：西安市胸科医院呼吸与危重症医学科，陕西 西安
关键词: 肺腺癌；液体活检；外泌体；研究进展；Lung Adenocarcinoma； Liquid Biopsy； Exosome； Research Progress
摘要: 肺腺癌是最常见的恶性肿瘤之一，其发病率和死亡率逐年上升。肺腺癌在早期阶段没有特异性的临床症状，缺乏有效的检测，使得早期发现变得困难。大多数患者在检测时已经处于晚期，预后差。肺癌细胞源性的外泌体(Lung cancer cell-derived exosomes, LCCDEs)由于其生物学功能和携带供体细胞生物分子的天然能力在肺腺癌的早期诊断及治疗中具有非常重要的作用，因此提高对外泌体的认识及研究对目前肺腺癌的早期诊断、早期治疗及预后有着十分重要的作用。本文就肺癌细胞源性外泌体在肺腺癌中的发生、诊断及治疗等研究进展做一综述。
Abstract: Lung adenocarcinoma is one of the most common malignant tumors, and its morbidity and mortality are increasing year by year. Lung adenocarcinoma has no specific clinical symptoms in its early stages, and the lack of effective detection makes early detection difficult. Most patients are already in an advanced stage at the time of detection and have a poor prognosis. Lung cancer cell-derived exosomes (LCCDEs) play an important role in the early diagnosis and treatment of lung adenocarcinoma due to their biological function and natural ability to carry donor cell biomolecules. Therefore, it is very important to improve the understanding and study of exosomes for the early diagnosis, treatment and prognosis of lung adenocarcinoma. This article reviews the progress in the development, diagnosis and treatment of lung cancer cell-derived exosomes in lung adenocarcinoma.
文章引用：王星昊, 刘兆云, 李建英. 外泌体在肺腺癌中的发生、诊断及治疗的作用和研究进展[J]. 临床个性化医学, 2025, 4(3): 313-320. https://doi.org/10.12677/jcpm.2025.43348

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