超声诊断胎儿甲状腺疾病的研究进展
Research Progress in the Ultrasonographic Diagnosis of Fetal Thyroid Diseases
摘要: 胎儿甲状腺发育的生理机制致使其甲状腺功能呈现出多变性与复杂性。近年来，随着甲状腺功能异常孕妇数量的逐年递增，甲状腺异常胎儿的数量也相应增多。胎儿甲状腺大小是甲状腺功能异常最早且最常见的敏感征象，超声检查作为一种经济、无创的手段，已广泛应用于胎儿甲状腺功能异常的产前诊断，能够在产前有效监测胎儿甲状腺大小的变化。
Abstract: The physiological mechanism of fetal thyroid development leads to the variability and complexity of its thyroid function. In recent years, with the annual increase in the number of pregnant women with abnormal thyroid function, the number of fetuses with thyroid abnormalities has also increased accordingly. The size of the fetal thyroid is the earliest and most common sensitive sign of abnormal thyroid function. As an economical and non-invasive method, ultrasound examination has been widely used in the prenatal diagnosis of fetal thyroid function abnormalities, and it can effectively monitor the changes in the size of the fetal thyroid before birth.
文章引用：贾泽楠, 刘晓宇, 周明远, 李晓婷. 超声诊断胎儿甲状腺疾病的研究进展[J]. 临床个性化医学, 2025, 4(3): 393-399. https://doi.org/10.12677/jcpm.2025.43358

参考文献

[1] 杨瑞琦, 祝贺, 张嘉玲, 王飞, 范丽梅. 超声对合并甲状腺功能亢进孕妇胎儿甲状腺功能的评估[J]. 中华医学杂志, 2014, 94(35): 2760-2762.
[2] Kurtoglu, S. and Ozdemir, A. (2017) Fetal Neonatal Hyperthyroidism: Diagnostic and Therapeutic Approachment. Türk Pediatri Arşivi, 52, 1-9. [Google Scholar] [CrossRef] [PubMed]
[3] Léger, J. (2016) Management of Fetal and Neonatal Graves’ Disease. Hormone Research in Paediatrics, 87, 1-6. [Google Scholar] [CrossRef] [PubMed]
[4] 李秀玲, 董旭东, 刘焕玲, 颜芳, 侯晴沙, 陈醇. 二维超声评估孕龄、双顶径与胎儿甲状腺大小相关性[J]. 昆明医科大学学报, 2021, 42(11): 45-50.
[5] Kim, M., Chae, Y., Park, S. and Kim, M. (2016) Intra-Amniotic Thyroxine to Treat Fetal Goiter. Obstetrics & Gynecology Science, 59, 66-70. [Google Scholar] [CrossRef] [PubMed]
[6] Stagnaro-Green, A., Abalovich, M., Alexander, E., Azizi, F., Mestman, J., Negro, R., et al. (2011) Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease during Pregnancy and Postpartum. Thyroid, 21, 1081-1125. [Google Scholar] [CrossRef] [PubMed]
[7] 唐军民, 李继承. 组织学与胚胎学[M]. 北京: 北京大学医学出版社, 2011: 323-346.
[8] Ho, S.S.Y. and Metreweli, C. (1998) Normal Fetal Thyroid Volume. Ultrasound in Obstetrics & Gynecology, 11, 118-122. [Google Scholar] [CrossRef] [PubMed]
[9] Luton, D., Le Gac, I., Vuillard, E., Castanet, M., Guibourdenche, J., Noel, M., et al. (2005) Management of Graves’ Disease during Pregnancy: The Key Role of Fetal Thyroid Gland Monitoring. The Journal of Clinical Endocrinology & Metabolism, 90, 6093-6098. [Google Scholar] [CrossRef] [PubMed]
[10] Kiefer, F.W., Klebermass-Schrehof, K., Steiner, M., et al. (2017) Fetal/Neonatal Thyrotoxicosis in a Newborn from a Hypothyroid Woman with Hashimoto Thyroiditis. The Journal of Clinical Endocrinology & Metabolism, 102, 6-9.
[11] Figueiredo, C.M., Falcão, I., Vilaverde, J., Freitas, J., Oliveira, M.J., Godinho, C., et al. (2018) Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism Due to Dyshormonogenesis. Case Reports in Endocrinology, 2018, Article ID: 9564737. [Google Scholar] [CrossRef] [PubMed]
[12] 刘彦英, 钱隽, 李谊, 黄春旺, 周瑞莉, 王银, 丛淑珍. 胎儿甲状腺的超声检测及其临床意义[J]. 中国超声医学杂志, 2014, 30(4): 350-352.
[13] Bernardes, L.S., Ruano, R., Sapienza, A.D., Maganha, C.A. and Zugaib, M. (2008) Nomograms of Fetal Thyroid Measurements Estimated by 2‐Dimensional Sonography. Journal of Clinical Ultrasound, 36, 193-199. [Google Scholar] [CrossRef] [PubMed]
[14] Ranzini, A.C., Ananth, C.V., Smulian, J.C., Kung, M., Limbachia, A. and Vintzileos, A.M. (2001) Ultrasonography of the Fetal Thyroid: Nomograms Based on Biparietal Diameter and Gestational Age. Journal of Ultrasound in Medicine, 20, 613-617. [Google Scholar] [CrossRef] [PubMed]
[15] 李敏, 李丽雅, 吕国荣, 林清清, 刘显兰. 三维超声检测胎儿甲状腺体积[J]. 中国医学影像技术, 2013, 29(1): 158-160.
[16] Bernardes, L.S., Ruano, R., Sapienza, A.D., Maganha, C.A. and Zugaib, M. (2008) Nomograms of Fetal Thyroid Measurements Estimated by 2‐dimensional Sonography. Journal of Clinical Ultrasound, 36, 193-199. [Google Scholar] [CrossRef] [PubMed]
[17] Gietka-Czernel, M., Dębska, M., Kretowicz, P., Dębski, R. and Zgliczyński, W. (2012) Fetal Thyroid in Two-Dimensional Ultrasonography: Nomograms According to Gestational Age and Biparietal Diameter. European Journal of Obstetrics & Gynecology and Reproductive Biology, 162, 131-138. [Google Scholar] [CrossRef] [PubMed]
[18] 李丽雅, 吕国荣, 李敏, 凌乐文. 产前超声建立胎儿甲状腺正常参考值[J]. 中国医学影像技术, 2014, 30(6): 897-900.
[19] 相泓冰. 胎儿甲状腺的超声检测及其临床意义[J]. 中国伤残医学, 2016(4): 199-200.
[20] 花秋菊, 项宇识. 正常妊娠中晚期胎儿甲状腺体积的超声检测及分析[J]. 大连医科大学学报, 2017, 39(5): 475-477.
[21] Lapointe, S., Rottembourg, D. and Dallaire, F. (2020) Isolated Fetal Sinus Bradycardia as a First Sign of Congenital Hypopituitarism. CJC Open, 2, 420-422. [Google Scholar] [CrossRef] [PubMed]
[22] 孙伟杰. 胎儿甲状腺疾病的诊断和处理[J]. 中华产科急救电子杂志, 2023, 12(4): 212-216.
[23] Huel, C., Guibourdenche, J., Vuillard, E., Ouahba, J., Piketty, M., Oury, J.F., et al. (2009) Use of Ultrasound to Distinguish between Fetal Hyperthyroidism and Hypothyroidism on Discovery of a Goiter. Ultrasound in Obstetrics & Gynecology, 33, 412-420. [Google Scholar] [CrossRef] [PubMed]
[24] 李素娟, 丁文波, 武心萍, 邓学东. 超声多参数联合评分在甲状腺功能异常孕妇的新生儿甲状腺功能异常的预测价值[J]. 中国临床医学影像杂志, 2023, 34(4): 259-262.
[25] 宋亚男, 刘建. 超声筛查胎儿甲状腺前后径、横径及甲状腺功能评分对甲状腺功能异常孕妇新生儿甲状腺功能异常的预测模型[J]. 中外女性健康研究, 2024(7): 108-110.
[26] 于冬梅, 孙慧, 张楠, 等. 产前超声诊断及其预后: 5例病例分析[J]. 中华围产医学杂志, 2023, 26(12): 1002-1006.
[27] 李琴, 李亮, 贺小进, 等. 胎儿甲状腺肿大合并甲状腺功能减退的产前诊断及干预: 3例分析[J]. 中华围产医学杂志, 2023, 26(9): 760-765.
[28] 张静, 于泽堃, 付佳, 等. 产前超声检测胎儿甲状腺肿并甲状腺分泌障碍6型1例[J]. 中华新生儿科杂志, 2022, 37(3): 265-266.
[29] 武玺宁, 欧阳云淑, 戴晴, 等. 产前超声诊断胎儿甲状腺肿并先天性甲状腺功能减低1例[J]. 中华超声影像学杂志, 2024, 33(8): 688-690.
[30] 秦硕, 孙伟杰, 高莹, 等. Graves病合并妊娠患者胎儿甲状腺肿诊治经验[J]. 中华医学杂志, 2022, 102(6): 442-444.
[31] 张纯清. 胎儿甲状腺的增龄测量[J]. 现代中西医结合杂志, 2009, 18(5): 528-529.
[32] 陈志国, 杨建华, 申彪. 豫北地区胎儿甲状腺形态学观测[C]//中国解剖学会科技开发和咨询工作委员会. 第三届全国解剖学技术会议论文集. 新乡: 新乡医学院基础医学院, 2011: 84-85.