维生素D在宫颈病变及宫颈癌中的研究进展
Research Progress of Vitamin D in Cervical Lesions and Cervical Cancer
DOI: 10.12677/acm.2025.1561740, PDF,   
作者: 韩睿文：西安医学院第一附属医院妇科，陕西 西安；西安医学院研究生工作部，陕西 西安；张少华*：西安医学院第一附属医院妇科，陕西 西安
关键词: 维生素D；宫颈病变；宫颈癌；Vitamin D； Cervical Lesions； Cervical Cancer
摘要: 近年来，国内外大量的研究是关于维生素D及维生素D受体(Vitamin D Receptor, VDR)在癌症发生、发展中所起的作用。维生素D除了维持体内矿物质的稳态和骨骼的功能外，还具有抑制细胞增殖、诱导细胞分化、凋亡及免疫调节的作用。近些年，越来越多的研究表明，维生素D及维生素D受体在宫颈病变及宫颈癌的发病机制中发挥着重要的作用，未来可能会成为宫颈病变及宫颈癌治疗手段中新的切入点。现就维生素D及其受体在宫颈病变及宫颈癌研究现状进行综述。
Abstract: In recent years, a large number of studies at home and abroad have focused on the role of vitamin D and vitamin D receptor (VDR) in the occurrence and development of cancer. In addition to maintaining mineral homeostasis and bone function, vitamin D also has the function of inhibiting cell proliferation, inducing cell differentiation, apoptosis and immune regulation. In recent years, more and more studies have shown that vitamin D and vitamin D receptors play an important role in the pathogenesis of cervical lesions and cervical cancer, and may become a new entry point in the treatment of cervical lesions and cervical cancer in the future. This article reviews the research status of vitamin D and its receptors in cervical lesions and cervical cancer.
文章引用：韩睿文, 张少华. 维生素D在宫颈病变及宫颈癌中的研究进展[J]. 临床医学进展, 2025, 15(6): 408-412. https://doi.org/10.12677/acm.2025.1561740

参考文献

[1] Jia, H., Ding, L., Han, Y., Lyu, Y., Hao, M., Tian, Z., et al. (2021) Genotype-Specific Distribution and Change of High-Risk Human Papillomavirus Infection and the Association with Cervical Progression Risk in Women with Normal Pathology and Abnormal Cytology in a Population-Based Cohort Study in China. Journal of Cancer, 12, 4379-4388. [Google Scholar] [CrossRef] [PubMed]
[2] Zhang, R. and Naughton, D.P. (2010) Vitamin D in Health and Disease: Current Perspectives. Nutrition Journal, 9, Article No. 65. [Google Scholar] [CrossRef] [PubMed]
[3] Bikle, D.D. (2016) Extraskeletal Actions of Vitamin D. Annals of the New York Academy of Sciences, 1376, 29-52. [Google Scholar] [CrossRef] [PubMed]
[4] 张强, 郭苗苗, 张涛, 路宏朝, 王珊珊, 王令. 维生素D及其受体介导microRNA的抗癌作用机制研究进展[J]. 陕西理工大学学报(自然科学版) 2020, 36(6): 60-68.
[5] Jeon, S. and Shin, E. (2018) Exploring Vitamin D Metabolism and Function in Cancer. Experimental & Molecular Medicine, 50, 1-14. [Google Scholar] [CrossRef] [PubMed]
[6] Liu, Y. and Ai, H. (2024) Comprehensive Insights into Human Papillomavirus and Cervical Cancer: Pathophysiology, Screening, and Vaccination Strategies. Biochimica et Biophysica Acta (BBA)—Reviews on Cancer, 1879, Article ID: 189192. [Google Scholar] [CrossRef] [PubMed]
[7] Olusola, P., Banerjee, H.N., Philley, J.V. and Dasgupta, S. (2019) Human Papilloma Virus-Associated Cervical Cancer and Health Disparities. Cells, 8, Article No. 622. [Google Scholar] [CrossRef] [PubMed]
[8] Hosono, S., Matsuo, K., Kajiyama, H., Hirose, K., Suzuki, T., Kawase, T., et al. (2010) Association between Dietary Calcium and Vitamin D Intake and Cervical Carcinogenesis among Japanese Women. European Journal of Clinical Nutrition, 64, 400-409. [Google Scholar] [CrossRef] [PubMed]
[9] Li, D., Liu, Y., Kong, D., Papukashvili, D., Rcheulishvili, N., Zhao, H., et al. (2022) Vitamin D Receptor Gene Polymorphisms and the Risk of CIN2+ in Shanxi Population. BioMed Research International, 2022, Article ID: 6875996. [Google Scholar] [CrossRef] [PubMed]
[10] Vahedpoor, Z., Jamilian, M., Bahmani, F., Aghadavod, E., Karamali, M., Kashanian, M., et al. (2017) Effects of Long-Term Vitamin D Supplementation on Regression and Metabolic Status of Cervical Intraepithelial Neoplasia: A Randomized, Double-Blind, Placebo-Controlled Trial. Hormones and Cancer, 8, 58-67. [Google Scholar] [CrossRef] [PubMed]
[11] 毛惠娟, 黄国琴, 杨棹霞, 叶火红. 血清25-(OH)D与持续性高危型HPV感染的相关性及意义[J]. 中国计划生育学杂志, 2023, 31(11): 2758-2764.
[12] 曹蕾, 上官改珍, 白雯. 1,25-(OH)2D3在宫颈良性病变和宫颈癌患者中的表达水平及临床意义[J]. 实用癌症杂志 2019, 34(9): 1409-1411.
[13] Wu, Q., Zhang, L., Sun, Y. and Ying, J. (2024) Vitamin D-Regulated miR-589-3p in Patients with Cervical Cancer Predicts Patient Prognosis and Is Involved in Tumor Progression. Nutrition and Cancer, 76, 840-848. [Google Scholar] [CrossRef] [PubMed]
[14] González-Duarte, R.J., Cázares-Ordoñez, V., Romero-Córdoba, S., Díaz, L., Ortíz, V., Freyre-González, J.A., et al. (2015) Calcitriol Increases Dicer Expression and Modifies the microRNAs Signature in Siha Cervical Cancer Cells. Biochemistry and Cell Biology, 93, 376-384. [Google Scholar] [CrossRef] [PubMed]

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