联合检测凝血指标与CEA对结肠癌的诊断价值及诊断意义

The Diagnostic Value and Significance of Combined Detection of Coagulation Indicators and CEA for Colon Cancer

摘要: 目的：本研究旨在评估纤维蛋白原/前白蛋白比值(Fibrinogen-Prealbumin Ratio, FPR)联合纤维蛋白原(Fibrinogen, FIB)、D-二聚体(D-dimer, D-D)及癌胚抗原(Carcinoembryonic antigen, CEA)检测对结肠癌的诊断价值。通过多指标联合检测策略，系统分析这些血清标志物在结肠癌筛查和诊断中的临床应用潜力。方法：本研究选取2021年10月至2024年10月期间在北华大学附属医院接受诊治的140例患者作为研究对象。病例组纳入70例经病理学确诊并接受手术治疗的结肠癌患者，对照组纳入70例经结肠镜检查确诊的结肠良性病变患者。对两组患者术前的FPR、FIB、D-D、CEA水平及术后病理资料进行差异性分析，并绘制受试者工作特征曲线(ROC)。结果：1. 在结肠癌组患者中，血清FPR、FIB、D-D、CEA水平均高于对照组，且这种差异在统计学上具有显著性(Z = 7.469, P < 0.001; Z = 8.485, P < 0.001; Z = 8.201, P < 0.001; Z = 8.905, P < 0.001)。2. 对结肠癌患者的病理资料进行分析发现：TNM分期、淋巴结转移与FIB有关(U = 393.00, P = 0.010; U = 438.50, P = 0.041)，肿瘤大小与FPR有关(U = 416.00, P = 0.024)。3. FPR、FIB、D-D、CEA 及联合检测的曲线下面积分别为0.812、0.780、0.765、0.844、0.880。结论：联合检测FPR、FIB、D-D和CEA，可显著提升结肠癌诊断效能。

Abstract: Objective: This study aims to evaluate the fibrinogen-prealbumin Ratio (FPR) combined with Fibrinogen (FIB) and D-dimer. The diagnostic value of D-D and Carcinoembryonic antigen (CEA) detection for colon cancer. Through the multi-index combined detection strategy, the clinical application potential of these serum markers in the screening and diagnosis of colon cancer was systematically analyzed. Method: In this study, 140 patients who were diagnosed and treated at the Affiliated Hospital of Beihua University from October 2021 to October 2024 were selected as the research subjects. The case group included 70 patients with colon cancer who were pathologically diagnosed and received surgical treatment, while the control group included 70 patients with benign colon lesions diagnosed by colonoscopy. The differences in the levels of FPR, FIB, D-D, CEA before the operation and the postoperative pathological data of the two groups of patients were analyzed, and the receiver operating characteristic curve (ROC) was drawn. Result: 1. The levels of serum FPR, FIB, D-D and CEA in the colon cancer group were higher than those in the control group, and the differences were statistically significant (Z = 7.469, P < 0.001; Z = 8.485, P < 0.001; Z = 8.201, P < 0.001; Z = 8.905, P < 0.001). 2. Analysis of the pathological data of patients with colon cancer revealed that TNM stage and lymph node metastasis were related to FIB (U = 393.00, P = 0.010; U = 438.50, P = 0.041), and the tumor size was related to FPR (U = 416.00, P = 0.024). 3. The areas under the curves of FPR, FIB, D-D, CEA and combined detection were 0.812, 0.780, 0.765, 0.844 and 0.880 respectively. Conclusion: The combined detection of FPR, FIB, D-D and CEA can significantly improve the diagnostic efficacy of colon cancer.