甲状腺激素抵抗综合征研究综述
Resistance to Thyroid Hormone: A Review
DOI: 10.12677/acm.2025.1561866, PDF,    科研立项经费支持
作者: 刘睿琪:山东大学齐鲁医院内分泌与代谢病科,山东 济南;董 明*:山东大学齐鲁医院内分泌与代谢病科,山东 济南;山东省内分泌代谢病时空调节与精准干预重点实验室,代谢性慢病防治前沿技术山东省工程研究中心,山东大学内分泌代谢病研究所,山东 济南
关键词: 甲状腺激素抵抗综合征甲状腺激素受体基因突变Resistance to Thyroid Hormone Thyroid Hormone Receptors Gene Mutation
摘要: 甲状腺激素抵抗综合征(Resistance to Thyroid Hormone, RTH)是人体靶组织对甲状腺激素反应性降低导致的综合征,其最常见的病因是甲状腺激素受体的基因突变。RTH的生化特征及临床表现各异,同时RTH还可合并其他各类疾病,临床上常常误诊。总而言之,RTH的诊断及治疗目前仍然较为棘手。本文就RTH的相关研究作一综述,旨在提高对RTH的认识,减少误诊率。
Abstract: Resistance to Thyroid Hormone (RTH) is a syndrome caused by reduced responsiveness of human target tissues to thyroid hormones. The most common etiology is gene mutation of thyroid hormone receptors. RTH is characterized by heterogeneous biochemical features and clinical manifestations. Additionally, RTH may be complicated with various comorbidities, often leading to clinical misdiagnosis. In summary, the diagnosis and treatment of RTH remain challenging currently. This article provides a short review of relevant research on RTH, aiming to enhance the understanding of this disease and reduce the misdiagnosis rate.
文章引用:刘睿琪, 董明. 甲状腺激素抵抗综合征研究综述[J]. 临床医学进展, 2025, 15(6): 1406-1413. https://doi.org/10.12677/acm.2025.1561866

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