纳米材料在溃疡性结肠炎治疗中的创新策略与应用前景
Innovative Strategies and Application Prospects of Nanomaterials in Ulcerative Colitis Therapy
DOI: 10.12677/acm.2025.1571965, PDF,    科研立项经费支持
作者: 孙尚国, 许克伟, 史红岩, 陈 燕, 盛淑婷, 刘汝冰*：阜阳师范大学附属阜南医院消化内科，安徽 阜阳
关键词: 纳米材料；溃疡性结肠炎；治疗策略；药物传递；抗炎；Nanomaterials； Ulcerative Colitis； Therapeutic Strategies； Drug Delivery； Anti-Inflammatory
摘要: 溃疡性结肠炎是一种慢性炎症性肠病，其病因尚未完全明确，治疗手段有限，给患者带来了较大的生活困扰和健康风险。近年来，随着纳米技术的发展，纳米材料因其独特的物理化学性质和良好的生物相容性，逐渐成为溃疡性结肠炎治疗的新兴策略。当前，纳米材料在靶向药物传递、抗炎作用、康复辅助以及再生医学等领域的应用现状显示出良好的前景，但仍存在一些挑战和问题亟待解决。本文旨在综述纳米材料在溃疡性结肠炎治疗中的应用进展，探讨其潜在的创新策略，并展望未来的应用前景，以期为相关研究提供参考和启示。
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with incompletely understood etiology and limited therapeutic options, imposing substantial lifestyle burdens and health risks on patients. In recent years, advancements in nanotechnology have positioned nanomaterials as a promising strategy for UC treatment due to their unique physicochemical properties and excellent biocompatibility. Current applications of nanomaterials in targeted drug delivery, anti-inflammatory interventions, rehabilitation support, and regenerative medicine demonstrate significant potential. However, persisting challenges, such as biocompatibility optimization, precise targeting, and long-term safety evaluation, require urgent resolution. This review systematically summarizes recent progress in nanomaterial-based UC therapies, explores innovative strategies to overcome existing limitations, and outlines future directions to advance clinical translation. The findings aim to provide valuable insights and references for interdisciplinary research in this evolving field.
文章引用：孙尚国, 许克伟, 史红岩, 陈燕, 盛淑婷, 刘汝冰. 纳米材料在溃疡性结肠炎治疗中的创新策略与应用前景[J]. 临床医学进展, 2025, 15(7): 115-122. https://doi.org/10.12677/acm.2025.1571965

参考文献

[1] Jia, Z., Yu, M., Wang, W., Ghazimirsaeid, S., Qu, Y. and Zhang, M. (2024) An Oxidative Cleavage-Based Cruciform DNA Nanostructure for in Vivo Hypochlorous Acid Visualization to Monitor Intestinal Inflammation. Analytical Chemistry, 96, 9621-9628. [Google Scholar] [CrossRef] [PubMed]
[2] Mondal, S., Das, M., Ghosh, R., Singh, M., Adhikari, A., Darbar, S., et al. (2023) Chitosan Functionalized Mn3O4 Nanoparticles Counteracts Ulcerative Colitis in Mice through Modulation of Cellular Redox State. Communications Biology, 6, Article No. 647. [Google Scholar] [CrossRef] [PubMed]
[3] Chen, M., Lan, H., Jin, K. and Chen, Y. (2023) Responsive Nanosystems for Targeted Therapy of Ulcerative Colitis: Current Practices and Future Perspectives. Drug Delivery, 30, Article ID: 2219427. [Google Scholar] [CrossRef] [PubMed]
[4] Zhao, X., Ma, S., Wen, J., Hu, D., Gao, J., Peng, Q., et al. (2022) Reactive Oxygen Species-Responsive Polyether Micelle Nanomaterials for Targeted Treatment of Ulcerative Colitis. Journal of Biomedical Nanotechnology, 18, 120-131. [Google Scholar] [CrossRef] [PubMed]
[5] Ma, L., Lyu, W., Song, Y., Chen, K., Lv, L., Yang, H., et al. (2023) Front Cover: Anti‐Inflammatory Effect of Clostridium butyricum‐Derived Extracellular Vesicles in Ulcerative Colitis: Impact on Host MicroRNAs Expressions and Gut Microbiome Profiles. Molecular Nutrition & Food Research, 67, e2200884. [Google Scholar] [CrossRef] 
[6] Lu, J., Shi, T., Shi, C., Chen, F., Yang, C., Xie, X., et al. (2023) Thiol-Disulfide Exchange Coordinates the Release of Nitric Oxide and Dexamethasone for Synergistic Regulation of Intestinal Microenvironment in Colitis. Research, 6, Article No. 0204. [Google Scholar] [CrossRef] [PubMed]
[7] Zhang, Y., Zhao, J., Zhao, Y., Bai, X., Chen, Y., Liu, Y., et al. (2023) The Rhei radix rhizoma-Based Carbon Dots Ameliorates Dextran Sodium Sulphate-Induced Ulcerative Colitis in Mice. Artificial Cells, Nanomedicine, and Biotechnology, 51, 180-191. [Google Scholar] [CrossRef] [PubMed]
[8] Kan, L., Zheng, Z., Fu, W., Ma, Y., Wang, W., Qian, H., et al. (2024) Recent Progress on Engineered Micro/Nanomaterials Mediated Modulation of Gut Microbiota for Treating Inflammatory Bowel Disease. Journal of Controlled Release, 370, 43-65. [Google Scholar] [CrossRef] [PubMed]
[9] Wang, H., Zhou, F., Shen, M., Ma, R. and Yu, Q. (2025) Classification of Nanomaterial Drug Delivery Systems for Inflammatory Bowel Disease. International Journal of Nanomedicine, 20, 1383-1399. [Google Scholar] [CrossRef] [PubMed]
[10] Cheng, C., Cheng, Y., Zhao, S., Wang, Q., Li, S., Chen, X., et al. (2021) Multifunctional Nanozyme Hydrogel with Mucosal Healing Activity for Single-Dose Ulcerative Colitis Therapy. Bioconjugate Chemistry, 33, 248-259. [Google Scholar] [CrossRef] [PubMed]
[11] Zhang, C., Li, Q., Shan, J., Xing, J., Liu, X., Ma, Y., et al. (2023) Multifunctional Two-Dimensional Bi2Se3 Nanodiscs for Anti-Inflammatory Therapy of Inflammatory Bowel Diseases. Acta Biomaterialia, 160, 252-264. [Google Scholar] [CrossRef] [PubMed]
[12] Wang, T., Fan, Q., Hong, J., Chen, Z., Zhou, X., Zhang, J., et al. (2021) Therapeutic Nanoparticles from Grape Seed for Modulating Oxidative Stress. Small, 17, e2102485. [Google Scholar] [CrossRef] [PubMed]
[13] Ranjha, M.M.A.N., Shafique, B., Rehman, A., Mehmood, A., Ali, A., Zahra, S.M., et al. (2022) Biocompatible Nanomaterials in Food Science, Technology, and Nutrient Drug Delivery: Recent Developments and Applications. Frontiers in Nutrition, 8, Article ID: 778155. [Google Scholar] [CrossRef] [PubMed]

为你推荐