COPD与肌少–骨质疏松症的影像学研究进展
Imaging Research Progress on COPD and Osteosarcopenia
摘要: 慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease, COPD)是一种严重影响生活质量和生存率的呼吸系统疾病，近年来，研究表明COPD患者常伴有肌骨合并症，这种并发症会加重病情及死亡风险。因此，利用影像学早期诊断和评估COPD合并症对于改善COPD患者的预后及死亡率至关重要。探索临床应用影像筛查并诊断COPD患者并发肌骨合并症已成为重要的研究方向。
Abstract: Chronic obstructive pulmonary disease (COPD) is a respiratory disease that severely affects quality of life and survival rates. Recent studies have shown that COPD patients often have osteosarcopenia, which can exacerbate the condition and increase mortality risk. Therefore, the early diagnosis and assessment of COPD comorbidities using imaging techniques are crucial for improving the prognosis and mortality rates of COPD patients. Exploring the clinical application of imaging screening and diagnosis for musculoskeletal comorbidities in COPD patients has become an important research direction.
文章引用：郭瑞. COPD与肌少–骨质疏松症的影像学研究进展[J]. 临床医学进展, 2025, 15(7): 321-325. https://doi.org/10.12677/acm.2025.1571992

参考文献

[1] Pauwels, R.A., Buist, A.S., Ma, P., Jenkins, C.R., Hurd, S.S., GOLD Scientific Committee (2001) Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease: National Heart, Lung, and Blood Institute and World Health Organization Global Initiative for Chronic Obstructive Lung Disease (GOLD): Executive Summary. Respiratory Care, 46, 798-825.
[2] Wang, C., et al. (2018) Prevalence and Risk Factors of chronic Obstructive Pulmonary Disease in China (the China Pulmonary Health [CPH] Study): A National Cross-Sectional Study. The Lancet, 391, 1706-1717.
[3] Habraken, J.M., van der Wal, W.M., ter Riet, G., Weersink, E.J.M., Toben, F. and Bindels, P.J.E. (2010) Health-Related Quality of Life and Functional Status in End-Stage COPD: A Longitudinal Study. European Respiratory Journal, 37, 280-288. [Google Scholar] [CrossRef] [PubMed]
[4] Janssen, D.J.A., Franssen, F.M.E., Wouters, E.F.M., Schols, J.M.G.A. and Spruit, M.A. (2011) Impaired Health Status and Care Dependency in Patients with Advanced COPD or Chronic Heart Failure. Quality of Life Research, 20, 1679-1688. [Google Scholar] [CrossRef] [PubMed]
[5] Majumdar, S.R., Villa-Roel, C., Lyons, K.J. and Rowe, B.H. (2010) Prevalence and Predictors of Vertebral Fracture in Patients with Chronic Obstructive Pulmonary Disease. Respiratory Medicine, 104, 260-266. [Google Scholar] [CrossRef] [PubMed]
[6] Yu, X., Sun, S., Zhang, S., Hao, Q., Zhu, B., Teng, Y., et al. (2022) A Pooled Analysis of the Association between Sarcopenia and Osteoporosis. Medicine, 101, e31692. [Google Scholar] [CrossRef] [PubMed]
[7] 王青青, 苏晓雨, 彭玉晓, 等. 基于CT的骨骼肌参数诊断肿瘤病人肌少症[J]. 国际医学放射学杂志, 2021, 44(3): 324-329.
[8] 黄宏兴, 史晓林, 李盛华, 等. 肌少-骨质疏松症专家共识[J]. 中国骨质疏松杂志, 2022, 28(11): 1561-1570.
[9] Huo, Y.R., Suriyaarachchi, P., Gomez, F., Curcio, C.L., Boersma, D., Muir, S.W., et al. (2015) Phenotype of Osteosarcopenia in Older Individuals with a History of Falling. Journal of the American Medical Directors Association, 16, 290-295. [Google Scholar] [CrossRef] [PubMed]
[10] Wilson, A.C., Bon, J.M., Mason, S., Diaz, A.A., Lutz, S.M., Estepar, R.S.J., et al. (2022) Increased Chest CT Derived Bone and Muscle Measures Capture Markers of Improved Morbidity and Mortality in COPD. Respiratory Research, 23, Article No. 311. [Google Scholar] [CrossRef] [PubMed]
[11] Lee, J.S.W., Auyeung, T., Kwok, T., Lau, E.M.C., Leung, P. and Woo, J. (2007) Associated Factors and Health Impact of Sarcopenia in Older Chinese Men and Women: A Cross-Sectional Study. Gerontology, 53, 404-410. [Google Scholar] [CrossRef] [PubMed]
[12] Dey, D.K., Bosaeus, I., Lissner, L. and Steen, B. (2009) Changes in Body Composition and Its Relation to Muscle Strength in 75-Year-Old Men and Women: A 5-Year Prospective Follow-Up Study of the NORA Cohort in Göteborg, Sweden. Nutrition, 25, 613-619. [Google Scholar] [CrossRef] [PubMed]
[13] Smith, M. and Wrobel, J. (2014) Epidemiology and Clinical Impact of Major Comorbidities in Patients with COPD. International Journal of Chronic Obstructive Pulmonary Disease, 9, 871-888. [Google Scholar] [CrossRef] [PubMed]
[14] Bordoni, B., Marelli, F., Morabito, B., Sacconi, B., Caiazzo, P. and Castagna, R. (2018) Low Back Pain and Gastroesophageal Reflux in Patients with COPD: The Disease in the Breath. International Journal of Chronic Obstructive Pulmonary Disease, 13, 325-334. [Google Scholar] [CrossRef] [PubMed]
[15] Cruz-Jentoft, A.J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., et al. (2018) Sarcopenia: Revised European Consensus on Definition and Diagnosis. Age and Ageing, 48, 16-31. [Google Scholar] [CrossRef] [PubMed]
[16] Papaioannou, A., Watts, N.B., Kendler, D.L., Yuen, C.K., Adachi, J.D. and Ferko, N. (2002) Diagnosis and Management of Vertebral Fractures in Elderly Adults. The American Journal of Medicine, 113, 220-228. [Google Scholar] [CrossRef] [PubMed]
[17] Chen, Y., Ramsook, A.H., Coxson, H.O., Bon, J. and Reid, W.D. (2019) Prevalence and Risk Factors for Osteoporosis in Individuals with COPD: A Systematic Review and Meta-Analysis. Chest, 156, 1092-1110. [Google Scholar] [CrossRef] [PubMed]
[18] Cooper, C., Atkinson, E.J., MichaelO’Fallon, W. and Dr. Melton, J.L. (1992) Incidence of Clinically Diagnosed Vertebral Fractures: A Population-Based Study in Rochester, Minnesota, 1985-1989. Journal of Bone and Mineral Research, 7, 221-227. [Google Scholar] [CrossRef] [PubMed]
[19] Wang, Y., Wang, Y., Zhan, J., Tang, Z., He, J., Tan, P., et al. (2015) Sarco-Osteoporosis: Prevalence and Association with Frailty in Chinese Community-Dwelling Older Adults. International Journal of Endocrinology, 2015, Article ID: 482940. [Google Scholar] [CrossRef] [PubMed]
[20] Clynes, M.A., Gregson, C.L., Bruyère, O., Cooper, C. and Dennison, E.M. (2020) Osteosarcopenia: Where Osteoporosis and Sarcopenia Collide. Rheumatology, 60, 529-537. [Google Scholar] [CrossRef] [PubMed]
[21] Hwang, J.A., Kim, Y.S., Leem, A.Y., Park, M.S., Kim, S.K., Chang, J., et al. (2017) Clinical Implications of Sarcopenia on Decreased Bone Density in Men with COPD. Chest, 151, 1018-1027. [Google Scholar] [CrossRef] [PubMed]
[22] Kirk, B., Miller, S., Zanker, J. and Duque, G. (2020) A Clinical Guide to the Pathophysiology, Diagnosis and Treatment of Osteosarcopenia. Maturitas, 140, 27-33. [Google Scholar] [CrossRef] [PubMed]
[23] Bodduluri, S., Reinhardt, J.M., Hoffman, E.A., Newell, J.D., Nath, H., Dransfield, M.T., et al. (2017) Signs of Gas Trapping in Normal Lung Density Regions in Smokers. American Journal of Respiratory and Critical Care Medicine, 196, 1404-1410. [Google Scholar] [CrossRef] [PubMed]
[24] Arceo-Mendoza, R.M. and Camacho, P.M. (2021) Postmenopausal Osteoporosis. Endocrinology and Metabolism Clinics of North America, 50, 167-178. [Google Scholar] [CrossRef] [PubMed]
[25] Lupsa, B.C. and Insogna, K. (2015) Bone Health and Osteoporosis. Endocrinology and Metabolism Clinics of North America, 44, 517-530. [Google Scholar] [CrossRef] [PubMed]
[26] Adams, J.E. (2009) Quantitative Computed Tomography. European Journal of Radiology, 71, 415-424. [Google Scholar] [CrossRef] [PubMed]
[27] Moayyeri, A., Adams, J.E., Adler, R.A., Krieg, M., Hans, D., Compston, J., et al. (2011) Quantitative Ultrasound of the Heel and Fracture Risk Assessment: An Updated Meta-Analysis. Osteoporosis International, 23, 143-153. [Google Scholar] [CrossRef] [PubMed]
[28] Chen, L.-K., Woo, J., Assantachai, P., et al. (2020) Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. Journal of the American Medical Directors Association, 21, 300-307.e2.
[29] Boutin, R.D., Yao, L., Canter, R.J. and Lenchik, L. (2015) Sarcopenia: Current Concepts and Imaging Implications. American Journal of Roentgenology, 205, W255-W266. [Google Scholar] [CrossRef] [PubMed]
[30] Beaudart, C., McCloskey, E., Bruyère, O., Cesari, M., Rolland, Y., Rizzoli, R., et al. (2016) Sarcopenia in Daily Practice: Assessment and Management. BMC Geriatrics, 16, Article No. 170. [Google Scholar] [CrossRef] [PubMed]
[31] Schweitzer, L., Geisler, C., Pourhassan, M., Braun, W., Glüer, C., Bosy-Westphal, A., et al. (2015) What Is the Best Reference Site for a Single MRI Slice to Assess Whole-Body Skeletal Muscle and Adipose Tissue Volumes in Healthy Adults? The American Journal of Clinical Nutrition, 102, 58-65. [Google Scholar] [CrossRef] [PubMed]
[32] Amini, B., Boyle, S.P., Boutin, R.D. and Lenchik, L. (2019) Approaches to Assessment of Muscle Mass and Myosteatosis on Computed Tomography: A Systematic Review. The Journals of Gerontology: Series A, 74, 1671-1678. [Google Scholar] [CrossRef] [PubMed]
[33] Vestbo, J. and Rennard, S. (2010) Chronic Obstructive Pulmonary Disease Biomarker(s) for Disease Activity Needed—Urgently. American Journal of Respiratory and Critical Care Medicine, 182, 863-864. [Google Scholar] [CrossRef] [PubMed]

为你推荐