骨关节炎治疗研究进展

Research Progress in the Treatment of Osteoarthritis

摘要: 骨关节炎(OA)是关节炎最常见的形式，影响65岁以上的三分之一的人。随着时代进展OA的患病率正在逐年上升，OA相关的关节疼痛可导致功能限制、睡眠不良、疲劳、情绪低落和丧失生活独立性。患者由于生产力损失而产生更高的自付健康相关支出和大量成本。OA的病理生理学尚未得到充分研究，目前尚无法根治。目前有非药物治疗、药物治疗、手术治疗3种手段，最为广泛使用的仍是药物治疗，且中医药在治疗OA中越发到重视，深入研究中药治疗OA的作用机制可为早期治疗提供新治疗方案，同时相关作用机制的研究可能为未来OA的治疗提供新靶点，从而减缓或者治愈这种慢性且致残性疾病的进展。

Abstract: Osteoarthritis (OA) is the most common form of arthritis, affecting one-third of individuals over the age of 65. As time progresses, the prevalence of OA is rising year by year. OA-related joint pain can lead to functional limitations, poor sleep, fatigue, mood depression, and a loss of independence in daily life. Patients also face higher out-of-pocket health-related expenses and substantial costs due to productivity losses. The pathophysiology of OA is not yet fully understood, and there is currently no cure. At present, there are three kinds of non-drug treatment, drug treatment and surgical treatment, and the most widely used is still drug treatment, and traditional Chinese medicine has paid more and more attention to the treatment of OA, and in-depth research on the mechanism of action of traditional Chinese medicine in the treatment of OA can provide new treatment options for early treatment, and the study of related mechanisms of action may provide new targets for the treatment of OA in the future, so as to slow down or cure the progression of this chronic and disabling disease.