循环免疫细胞和炎症因子水平与胎盘早剥的因果关联评估——一项孟德尔随机化研究
Assessment of the Causal Associations of Circulating Immune Cell and Inflammatory Factor Levels with Placental Abruption—A Mendelian Randomization Study
摘要: 目的：本研究采用孟德尔随机化(MR)和两步MR分析，探究免疫细胞和循环炎症因子与胎盘早剥的因果关系。方法：本研究从公开来源获取731个免疫细胞表型和91个循环炎症因子的遗传数据。胎盘早剥的结局数据来自芬兰基因组联盟(R9)，其中包括8812例欧洲血统病例和425,678例欧洲血统对照。研究采用逆方差加权法、敏感性分析和两步孟德尔随机化方法，来评估免疫细胞与胎盘早剥之间的因果关系，以及炎症因子在其中的潜在中介作用。结果：16种免疫细胞表型和5种循环炎症因子与胎盘早剥显著相关。研究发现CD6和TNF介导CD39+ CD8br细胞上的CD8对胎盘早剥产生影响。结论：本研究揭示特异性免疫细胞和炎症因子与胎盘早剥之间具有潜在因果关系，确定了预防和管理这种严重产科并发症的潜在生物标志物和治疗靶点。
Abstract: Objective: To investigate the causal effects of immune cells and circulating inflammatory proteins on placental abruption using Mendelian randomization (MR) and two-step MR analyses. Methods: Genetic data for 731 immune cell traits and 91 circulating inflammatory proteins were obtained from publicly available sources. Outcome data for placental abruption were obtained from the FinnGen consortium (R9), including 8812 cases and 425,678 controls of European descent. Inverse variance-weighted MR, sensitivity analyses, and two-step MR were performed to assess causal relationships and potential mediating roles of inflammatory proteins between immune cells and placental abruption. Results: Sixteen immune cell traits and five circulating inflammatory proteins were significantly associated with placental abruption. CD6 and TNF were found to mediate the effect of CD8 on CD39+ CD8br cells on placental abruption. Conclusion: This study provides evidence for the causal role of specific immune cells and inflammatory proteins in the development of placental abruption, identifying potential biomarkers and therapeutic targets for prevention and management of this serious obstetric complication.
文章引用：杨慧, 李钦柯, 杨竹. 循环免疫细胞和炎症因子水平与胎盘早剥的因果关联评估——一项孟德尔随机化研究[J]. 临床医学进展, 2025, 15(7): 399-407. https://doi.org/10.12677/acm.2025.1572002

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