基于肠道菌群探讨从脾胃论治膝骨关节炎的研究进展
Progress of Research on the Treatment of Knee Osteoarthritis from the Spleen and Stomach Theory Based on Intestinal Flora
DOI: 10.12677/acm.2025.1572022, PDF,   
作者: 李崇铭, 张久一：广西中医药大学第一临床医学院，广西 南宁；梅其杰*：广西中医药大学第一附属医院四肢骨伤科，广西 南宁
关键词: 肠道菌群；脾胃论；膝骨关节炎；Intestinal Flora； Spleen and Stomach Theory； Knee Osteoarthritis
摘要: 脾胃与肠道菌群之间存在着非常紧密的相互作用和联系，这种联系在膝骨关节炎的发生和发展过程中扮演着重要的角色。膝骨关节炎的发病和进展不仅与脾胃不能荣养膝关节有关，而且还与肠道菌群的失衡有着密不可分的联系。基于此，以健脾益气为治疗原则的药物，能够通过“脾胃–肠道菌群–膝骨关节炎”这一关系轴，对膝骨关节炎的病情进展产生积极的影响。从中医的脾胃理论角度来审视，肠道菌群的调节也是治疗膝骨关节炎的一个重要研究方向。因此，本文将对目前中医药领域中，从脾胃理论出发，通过调节肠道菌群来预防和治疗膝骨关节炎的研究进展进行综述分析，为后续的相关研究提供坚实的理论基础和明确的研究方向。
Abstract: There is a very close interaction and connection between the spleen and stomach and the intestinal flora, and this connection plays an important role in the onset and progression of osteoarthritis of the knee. The onset and progression of knee osteoarthritis are not only related to the inability of the spleen and stomach to nourish the knee joint, but also closely associated with the imbalance of the gut microbiota. Based on this, drugs that strengthen the spleen and enhance qi can positively affect the progression of osteoarthritis of the knee through the relationship axis of “spleen and stomach-intestinal flora-osteoarthritis of the knee”. From the perspective of the spleen and stomach theory of Chinese medicine, the regulation of intestinal flora is also an important research direction for the treatment of osteoarthritis of the knee. Therefore, this paper will review and analyze the current research progress in the field of Chinese medicine on the prevention and treatment of osteoarthritis of the knee by regulating the intestinal flora from the perspective of the spleen and stomach theory, so as to provide a solid theoretical foundation and a clear research direction for the subsequent related research.
文章引用：李崇铭, 梅其杰, 张久一. 基于肠道菌群探讨从脾胃论治膝骨关节炎的研究进展[J]. 临床医学进展, 2025, 15(7): 548-554. https://doi.org/10.12677/acm.2025.1572022

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