肺炎支原体感染相关生物标志物的研究进展
Research Progress on Biomarkers Related to Mycoplasma pneumoniae Pneumonia
DOI: 10.12677/acm.2025.1572024, PDF,    科研立项经费支持
作者: 黑倩雯, 王尉蓉, 雷 雯*：昆明医科大学第二附属医院呼吸与危重症医学科，云南 昆明
关键词: 肺炎支原体肺炎；生物标志物；重症；难治性；Mycoplasma pneumoniae Pneumonia； Biomarkers； Severe Case； Refractory
摘要: 肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia, MPP)是社区获得性肺炎的常见类型，由肺炎支原体(Mycoplasma pneumoniae, MP)感染引起，临床表现为干咳，常伴有头痛、发热和肌肉疼痛等症状。可通过分子检测、血清学抗体检测、快速抗原检测和分离培养多种实验室方式诊断。MP感染通常是自限性的，但部分患者仍需药物治疗，目前，大环内酯类药物是MPP患者的首选药物，但大环内酯类药物耐药率不断提高，导致治疗无效、病情加重，引起严重并发症及死亡，近年来有研究提出，血清生物标志物对MPP病情发展具有指导意义，本文就目前研究的血清生物标志物进行综述。
Abstract: Mycoplasma pneumoniae pneumonia (MPP) is a common type of community-acquired pneumonia, caused by Mycoplasma pneumoniae (MP) infection, characterized by dry cough, often accompanied by symptoms such as headache, fever, and muscle pain. At present, various laboratory methods such as molecular detection, serological antibody detection, rapid antigen detection, and isolation and cultivation can be used for diagnosis. MP infection is usually self-limiting, but some patients still require medication treatment. Macrolide antibiotics are the preferred drugs for MPP patients, but the resistance rate to Macrolide antibiotics continues to increase, leading to ineffective treatment and worsening of the condition. Currently, research suggests that serum biomarkers have guiding significance for the development of MPP. This article reviews the current research on serum biomarkers.
文章引用：黑倩雯, 王尉蓉, 雷雯. 肺炎支原体感染相关生物标志物的研究进展[J]. 临床医学进展, 2025, 15(7): 561-568. https://doi.org/10.12677/acm.2025.1572024

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