人参及人参皂苷在自身免疫性疾病中作用的研究进展
Research Progress on the Role of Ginseng and Ginsenosides in Autoimmune Diseases
DOI: 10.12677/acm.2025.1572036, PDF,    国家自然科学基金支持
作者: 梁丹丹, 杨少雷:济宁医学院临床医学院,山东 济宁;景德怀, 周广玺, 朱凤琴:济宁医学院附属医院消化内科,山东 济宁
关键词: 人参皂苷自身免疫性疾病作用机制Ginsenosides Autoimmune Diseases Mechanism of Action
摘要: 人参中所含的人参皂苷,是主要的活性组分,具有较高的药用价值,尤其在是由自身免疫紊乱引发的疾病中,如桥本氏甲状腺炎、溃疡性结肠炎、类风湿性关节炎及系统性红斑狼疮等多方面多系统疾病。与传统免疫抑制剂和激素疗法相较,人参皂苷具有化学构成多样、结构复杂、低毒性和轻微副作用的特点。其发挥作用的机理复杂多样,能够多方面地调控免疫细胞活性、细胞因子平衡及信号传导通路,维持免疫系统的微环境稳态,为深入研究和临床应用奠定了有力的理论基础,提供了新方法新思路。
Abstract: Ginsenosides, the core active components found in ginseng, have demonstrated remarkable medicinal potential, particularly in treating autoimmune disorders such as Hashimoto’s thyroiditis, ulcerative colitis, rheumatoid arthritis, and systemic lupus erythematosus. Compared to traditional immunosuppressants and hormone therapies, ginsenosides stand out due to their diverse chemical composition, complex structures, low toxicity, and minimal side effects. Their mechanisms of action are intricate, enabling multi-dimensional regulation of immune cell activity, cytokine balance, and signaling pathways, thereby maintaining the microenvironmental stability of the immune system. This provides a solid theoretical foundation and new approaches for further research and clinical applications.
文章引用:梁丹丹, 杨少雷, 景德怀, 周广玺, 朱凤琴. 人参及人参皂苷在自身免疫性疾病中作用的研究进展[J]. 临床医学进展, 2025, 15(7): 654-662. https://doi.org/10.12677/acm.2025.1572036

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