远端缺血后适应在缺血性脑卒中的研究进展
Research Progress on Remote Ischemic Postconditioning in Ischemic Stroke
DOI: 10.12677/acm.2025.1572039, PDF,   
作者: 周 妍：西安医学院研究生工作部，陕西 西安；刘展会*, 张西安, 皇甫慧源, 刘立承：西安市第九医院神经外科，陕西 西安
关键词: 远端缺血后适应；缺血性脑卒中；研究进展；Remote Ischemic Postconditioning； Ischemic Stroke； Research Progress
摘要: 缺血性脑卒中发病率高、致残率高、死亡率高，是一种严重影响人类身体健康的疾病。远端缺血后适应是一种新颖的干预手段，因其易操作，安全性高，为缺血性脑卒中提供治疗新思路。本文对远端缺血后适应在缺血性脑卒中的研究进展进行综述，包括其概念、作用机制以及相关研究现状，并对存在的问题进行分析，展望未来发展方向，以期为缺血性脑卒中的治疗提供新的思路和理论借鉴。
Abstract: Ischemic stroke, characterized by its high incidence, disability, and mortality rates, is a disease that severely jeopardizes human health. Remote ischemic postconditioning (RIPC), as a novel intervention strategy, offers new therapeutic approaches for ischemic stroke due to its ease of operation and high safety profile. This review summarizes recent advances in RIPC research for ischemic stroke, including its concept, mechanisms of action, and current research status, analyzes existing challenges, and explores future directions, aiming to provide novel insights and theoretical founda-tions for the treatment of ischemic stroke.
文章引用：周妍, 刘展会, 张西安, 皇甫慧源, 刘立承. 远端缺血后适应在缺血性脑卒中的研究进展[J]. 临床医学进展, 2025, 15(7): 675-679. https://doi.org/10.12677/acm.2025.1572039

参考文献

[1] 王露露, 张灿飞, 富奇志. 急性缺血性脑卒中静脉溶栓后促进神经功能改善的治疗研究现状[J]. 华西医学, 2025, 40(5): 798-804.
[2] Chugh, C. (2019) Acute Ischemic Stroke: Management Approach. Indian Journal of Critical Care Medicine, 23, S140-S146.
[3] Lin, L., Wang, X. and Yu, Z. (2016) Ischemia-Reperfusion Injury in the Brain: Mechanisms and Potential Therapeutic Strategies. Biochemistry & Pharmacology: Open Access, 5, Article 213. [Google Scholar] [CrossRef] [PubMed]
[4] 赵文博, 李思颉, 吉训明.《远隔缺血适应防治缺血性脑血管病中国专家共识》解读[J]. 中国脑血管病杂志, 2021, 18(9): 585-589.
[5] Zhao, W., Jiang, F., Li, S., Liu, G., Wu, C., Wang, Y., et al. (2021) Safety and Efficacy of Remote Ischemic Conditioning for the Treatment of Intracerebral Hemorrhage: A Proof-of-Concept Randomized Controlled Trial. International Journal of Stroke, 17, 425-433. [Google Scholar] [CrossRef] [PubMed]
[6] Murry, C.E., Jennings, R.B. and Reimer, K.A. (1986) Preconditioning with Ischemia: A Delay of Lethal Cell Injury in Ischemic Myocardium. Circulation, 74, 1124-1136. [Google Scholar] [CrossRef] [PubMed]
[7] Zhao, H., Sapolsky, R.M. and Steinberg, G.K. (2006) Interrupting Reperfusion as a Stroke Therapy: Ischemic Postconditioning Reduces Infarct Size after Focal Ischemia in Rats. Journal of Cerebral Blood Flow & Metabolism, 26, 1114-1121. [Google Scholar] [CrossRef] [PubMed]
[8] Hardt, J.L.S., Pohlmann, P., Reissfelder, C. and Rahbari, N.N. (2024) Remote Ischemic Preconditioning for Reduction of Ischemia-Reperfusion Injury after Hepatectomy: A Randomized Sham-Controlled Trial. Surgery, 175, 424-431. [Google Scholar] [CrossRef] [PubMed]
[9] Hess, D.C., Hoda, M.N. and Khan, M.B. (2016) Humoral Mediators of Remote Ischemic Conditioning: Important Role of eNOS/NO/Nitrite. In: Applegate, R., Chen, G., Feng, H. and Zhang, J., Eds., Acta Neurochirurgica Supplement, Springer International Publishing, 45-48. [Google Scholar] [CrossRef] [PubMed]
[10] Xu, Y., Xue, H., Zhao, P., Yang, Y., Ji, G., Yu, W., et al. (2016) Isoflurane Postconditioning Induces Concentration-And Timing-Dependent Neuroprotection Partly Mediated by the GluR2 AMPA Receptor in Neonatal Rats after Brain Hypoxia-Ischemia. Journal of Anesthesia, 30, 427-436. [Google Scholar] [CrossRef] [PubMed]
[11] Pignataro, G., Esposito, E., Sirabella, R., Vinciguerra, A., Cuomo, O., Di Renzo, G., et al. (2013) nNOS and p-Erk Involvement in the Neuroprotection Exerted by Remote Postconditioning in Rats Subjected to Transient Middle Cerebral Artery Occlusion. Neurobiology of Disease, 54, 105-114. [Google Scholar] [CrossRef] [PubMed]
[12] Qi, Z., Dong, W., Shi, W., et al. (2015) Bcl-2 Phosphorylation Trig Gers Autophagy Switch and Reduces Mitochondrial Damage in Limb Remote Ischemic Conditioned Rats after Ischemic Stroke. Translational Stroke Research, 6, 198-206.
[13] 程傲冰. 远端缺血后处理通过抑制自噬减轻新生大鼠脑缺氧缺血损伤的机制研究[D]: [博士学位论文]. 广州: 南方医科大学, 2019.
[14] Ren, C., Yan, Z., Wei, D., Gao, X., Chen, X. and Zhao, H. (2009) Limb Remote Ischemic Postconditioning Protects against Focal Ischemia in Rats. Brain Research, 1288, 88-94. [Google Scholar] [CrossRef] [PubMed]
[15] Kerendi, F., Kin, H., Halkos, M.E., Jiang, R., Zatta, A.J., Zhao, Z.-Q., et al. (2005) Remote Postconditioning. Basic Research in Cardiology, 100, 404-412. [Google Scholar] [CrossRef] [PubMed]
[16] Santos-García, D., Blanco, M., Serena, J., Rodríguez-Yáñez, M., Leira, R. and Castillo, J. (2011) Impaired Brachial Flow-Mediated Dilation Is a Predictor of a New-Onset Vascular Event after Stroke. Cerebrovascular Diseases, 32, 155-162. [Google Scholar] [CrossRef] [PubMed]
[17] li, Y., Liang, K., Zhang, L., Pan, R., Hu, Y. and Zhao, J. (2020) Remote Ischemic Post-Conditioning May Improve Post-Stroke Cognitive Impairment: A Pilot Single Center Randomized Controlled Trial. Journal of Stroke and Cerebrovascular Diseases, 29, Article 105217. [Google Scholar] [CrossRef] [PubMed]
[18] England, T.J., Hedstrom, A., O’Sullivan, S., Donnelly, R., Barrett, D.A., Sarmad, S., et al. (2017) RECAST (Remote Ischemic Conditioning after Stroke Trial): A Pilot Randomized Placebo Controlled Phase II Trial in Acute Ischemic Stroke. Stroke, 48, 1412-1415. [Google Scholar] [CrossRef] [PubMed]
[19] Landman, T.R., Schoon, Y., Warlé, M.C., Meijer, F.J., Leeuw, F.D. and Thijssen, D.H. (2022) The Effect of Repeated Remote Ischemic Postconditioning after an Ischemic Stroke (REPOST): A Randomized Controlled Trial. International Journal of Stroke, 18, 296-303. [Google Scholar] [CrossRef] [PubMed]
[20] Hougaard, K.D., Hjort, N., Zeidler, D., Sørensen, L., Nørgaard, A., Hansen, T.M., et al. (2014) Remote Ischemic Perconditioning as an Adjunct Therapy to Thrombolysis in Patients with Acute Ischemic Stroke: A Randomized Trial. Stroke, 45, 159-167. [Google Scholar] [CrossRef] [PubMed]
[21] Costa, J.F., Fontes-Carvalho, R. and Leite-Moreira, A.F. (2013) Pré-condicionamento isquémico remoto do miocárdio: dos mecanismos fisiopatológicos à aplicação na prática clínica. Revista Portuguesa de Cardiologia, 32, 893-904. [Google Scholar] [CrossRef] [PubMed]
[22] Meng, R., Asmaro, K., Meng, L., Liu, Y., Ma, C., Xi, C., et al. (2012) Upper Limb Ischemic Preconditioning Prevents Recurrent Stroke in Intracranial Arterial Stenosis. Neurology, 79, 1853-1861. [Google Scholar] [CrossRef] [PubMed]
[23] Meng, R., Ding, Y., Asmaro, K., Brogan, D., Meng, L., Sui, M., et al. (2015) Ischemic Conditioning Is Safe and Effective for Octo-and Nonagenarians in Stroke Prevention and Treatment. Neurotherapeutics, 12, 667-677. [Google Scholar] [CrossRef] [PubMed]
[24] Zhao, W., Zhang, J., Sadowsky, M.G., Meng, R., Ding, Y. and Ji, X. (2017) Remote Ischaemic Conditioning for Preventing and Treating Ischaemic Stroke. Cochrane Database of Systematic Reviews, No. 7, CD012503. [Google Scholar] [CrossRef] 

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