慢性鼻窦炎的免疫机制与个体化治疗研究进展
Research Progress on the Immunological Mechanisms and Personalized Treatment of Chronic Rhinosinusitis
DOI: 10.12677/acm.2025.1572047, PDF,    科研立项经费支持
作者: 郭 雅*, 惠丹妮, 寇 艳#:延安大学附属医院儿科,陕西 延安
关键词: 慢性鼻窦炎生物制剂精准医疗Chronic Rhinosinusitis Biologics Precision Medicine
摘要: 慢性鼻窦炎是一种常见的慢性炎症性疾病,常与哮喘和过敏性鼻炎共病。本文综述其流行病学特征、免疫分型及治疗进展,重点探讨生物制剂在精准治疗中的应用前景,为临床管理提供参考。
Abstract: Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease that frequently coexists with asthma and allergic rhinitis. This review summarizes the epidemiological characteristics, immunological classification, and treatment advances of CRS, with a particular focus on the application prospects of biologics in precision therapy, providing a reference for clinical management.
文章引用:郭雅, 惠丹妮, 寇艳. 慢性鼻窦炎的免疫机制与个体化治疗研究进展[J]. 临床医学进展, 2025, 15(7): 732-737. https://doi.org/10.12677/acm.2025.1572047

参考文献

[1] Huang, C., Wang, C., Fu, C., Huang, C., Chang, P., Chen, I., et al. (2016) The Link between Chronic Rhinosinusitis and Asthma: A Questionnaire-Based Study. Medicine, 95, e4294. [Google Scholar] [CrossRef] [PubMed]
[2] Hopkins, C., Lee, S.E., Klimek, L. and Soler, Z.M. (2022) Clinical Assessment of Chronic Rhinosinusitis. The Journal of Allergy and Clinical Immunology: In Practice, 10, 1406-1416. [Google Scholar] [CrossRef] [PubMed]
[3] Chee, J., Pang, K.W., Low, T., Wang, D.Y. and Subramaniam, S. (2022) Epidemiology and Aetiology of Chronic Rhinosinusitis in Asia—A Narrative Review. Clinical Otolaryngology, 48, 305-312. [Google Scholar] [CrossRef] [PubMed]
[4] Xu, X., Reitsma, S., Wang, D.Y. and Fokkens, W.J. (2021) Highlights in the Advances of Chronic Rhinosinusitis. Allergy, 76, 3349-3358. [Google Scholar] [CrossRef] [PubMed]
[5] Schwartz, B.S., Pollak, J.S., Bandeen‐Roche, K., Hirsch, A.G., Lehmann, A.E., Kern, R.C., et al. (2023) Sinus Inflammation and Chronic Rhinosinusitis Are Associated with a Diagnosis of New Onset Asthma in the Following Year. Allergy, 78, 2659-2668. [Google Scholar] [CrossRef] [PubMed]
[6] Lusk, R. (2006) Pediatric Chronic Rhinosinusitis. Current Opinion in Otolaryngology & Head & Neck Surgery, 14, 393-396. [Google Scholar] [CrossRef] [PubMed]
[7] Ramadan, H.H. (2023) Pediatric Chronic Rhinosinusitis. European Archives of Oto-Rhino-Laryngology, 281, 1131-1137. [Google Scholar] [CrossRef] [PubMed]
[8] Chang, E.H., Stern, D.A., Willis, A.L., Guerra, S., Wright, A.L. and Martinez, F.D. (2018) Early Life Risk Factors for Chronic Sinusitis: A Longitudinal Birth Cohort Study. Journal of Allergy and Clinical Immunology, 141, 1291-1297.e2. [Google Scholar] [CrossRef] [PubMed]
[9] Xie, X., Xuan, L., Zhao, Y., Wang, X. and Zhang, L. (2024) Diverse Endotypes of Chronic Rhinosinusitis and Clinical Implications. Clinical Reviews in Allergy & Immunology, 65, 420-432. [Google Scholar] [CrossRef] [PubMed]
[10] Butcher, M.J. and Zhu, J. (2021) Recent Advances in Understanding the Th1/Th2 Effector Choice. Faculty Reviews, 10, Article 30. [Google Scholar] [CrossRef] [PubMed]
[11] Orlandi, R.R., Kingdom, T.T., Smith, T.L., et al. (2021) International Consensus Statement on Allergy and Rhinology: Rhinosinusitis 2021. International Forum of Allergy & Rhinology, 11, 213-739.
[12] Wang, X., Zhang, N., Bo, M., Holtappels, G., Zheng, M., Lou, H., et al. (2016) Diversity of T H Cytokine Profiles in Patients with Chronic Rhinosinusitis: A Multicenter Study in Europe, Asia, and Oceania. Journal of Allergy and Clinical Immunology, 138, 1344-1353. [Google Scholar] [CrossRef] [PubMed]
[13] Tesmer, L.A., Lundy, S.K., Sarkar, S. and Fox, D.A. (2008) Th17 Cells in Human Disease. Immunological Reviews, 223, 87-113. [Google Scholar] [CrossRef] [PubMed]
[14] Huang, C., Chang, P., Huang, Y., Lee, T., Huang, C. and Wu, P. (2023) Clinical Characteristics of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps in Adolescents. Journal of Asthma and Allergy, 16, 1197-1206. [Google Scholar] [CrossRef] [PubMed]
[15] Cergan, R., Berghi, O.N., Dumitru, M., Vrinceanu, D., Manole, F. and Serboiu, C.S. (2023) Biologics for Chronic Rhinosinusitis—A Modern Option for Therapy. Life, 13, Article 2165. [Google Scholar] [CrossRef] [PubMed]
[16] Fokkens, W.J., Lund, V.J., Hopkins, C., et al. (2020) European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology, 58, 1-464.
[17] Casale, M., Moffa, A., Cassano, M., Carinci, F., Lopez, M.A., Trecca, E.M.C., et al. (2018) Saline Nasal Irrigations for Chronic Rhinosinusitis: From Everyday Practice to Evidence-Based Medicine. an Update. International Journal of Immunopathology and Pharmacology, 32, 1-6. [Google Scholar] [CrossRef] [PubMed]
[18] Messina, J.C., Offman, E., Carothers, J.L. and Mahmoud, R.A. (2019) A Randomized Comparison of the Pharmacokinetics and Bioavailability of Fluticasone Propionate Delivered via Xhance Exhalation Delivery System versus Flonase Nasal Spray and Flovent HFA Inhalational Aerosol. Clinical Therapeutics, 41, 2343-2356. [Google Scholar] [CrossRef] [PubMed]
[19] Brzost, J., Czerwaty, K., Dżaman, K., Ludwig, N., Piszczatowska, K. and Szczepański, M. (2022) Perspectives in Therapy of Chronic Rhinosinusitis. Diagnostics, 12, Article 2301. [Google Scholar] [CrossRef] [PubMed]
[20] Luo, Q., Deng, J., Xu, R., et al. (2014) Clinical Effect of Clarithromycin Therapy in Patients with Chronic Rhinosinusitis. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 49, 103-108.
[21] Haxel, B.R., Clemens, M., Karaiskaki, N., Dippold, U., Kettern, L. and Mann, W.J. (2014) Controlled Trial for Long‐Term Low‐Dose Erythromycin after Sinus Surgery for Chronic Rhinosinusitis. The Laryngoscope, 125, 1048-1055. [Google Scholar] [CrossRef] [PubMed]
[22] Alsharif, S., Jonstam, K., van Zele, T., Gevaert, P., Holtappels, G. and Bachert, C. (2019) Endoscopic Sinus Surgery for Type‐2 CRS WNP: An Endotype‐based Retrospective Study. The Laryngoscope, 129, 1286-1292. [Google Scholar] [CrossRef] [PubMed]
[23] Morse, J.C., Miller, C. and Senior, B. (2021) Management of Chronic Rhinosinusitis with Nasal Polyposis in the Era of Biologics. Journal of Asthma and Allergy, 14, 873-882. [Google Scholar] [CrossRef] [PubMed]
[24] Colque-Bayona, M., Hernández-Cano, N., Tomás-Pérez, M., Caballero, T., Quirce, S. and Domínguez-Ortega, J. (2024) Global Influence of Dupilumab on Quality of Life in a Severe Asthma Patient with T2 Multimorbidities: A Case Report on Atopic Dermatitis, Chronic Rhinosinusitis with Nasal Polyposis, and Eosinophilic Esophagitis. Journal of Asthma, 61, 762-765. [Google Scholar] [CrossRef] [PubMed]
[25] Silver, J., Deb, A., Laliberté, F., Gao, C. and Bhattacharyya, N. (2023) Real‐World Effectiveness of Mepolizumab in Severe Asthma and Chronic Rhinosinusitis in the United States: Impact of Comorbidity and Sinus Surgery. International Forum of Allergy & Rhinology, 14, 5-17. [Google Scholar] [CrossRef] [PubMed]
[26] Gibson, P.G., Prazma, C.M., Chupp, G.L., Bradford, E.S., Forshag, M., Mallett, S.A., et al. (2021) Mepolizumab Improves Clinical Outcomes in Patients with Severe Asthma and Comorbid Conditions. Respiratory Research, 22, Article No. 171. [Google Scholar] [CrossRef] [PubMed]
[27] Howarth, P., Chupp, G., Nelsen, L.M., Bradford, E.S., Bratton, D.J., Smith, S.G., et al. (2020) Severe Eosinophilic Asthma with Nasal Polyposis: A Phenotype for Improved Sinonasal and Asthma Outcomes with Mepolizumab Therapy. Journal of Allergy and Clinical Immunology, 145, 1713-1715. [Google Scholar] [CrossRef] [PubMed]