抑制素B、AMH及性激素在多囊卵巢综合征诊断的应用

The Application of Inhibin B, AMH and Sex Hormones in the Diagnosis of Polycystic Ovary Syndrome

摘要: 目的：探讨抑制素B结合AMH、性激素在多囊卵巢综合征(PCOS)疾病诊断中的应用。方法：回顾性分析，选取2022年6月~2023年6月在广州市妇女儿童医疗中心柳州医院就诊的PCOS患者50例作为试验组，取同期就诊的正常体检者50例作为对照组，所有参与者均需空腹抽血检测抑制素B、结合抗苗勒管激素(AMH)、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、睾酮(T)，分析试验组与对照组的血清INHB、AMH及性激素各项指标水平，采用单样本Koimogorov-Smimov检验、独立样本T检验和Logistic回归分析等统计学方法对数据进行分析。结果：PCOS组E2、FSH、INHB均高于对照组，P > 0.05，PCOS组AMH、T、LH活性高于对照组，P < 0.05，差异具有统计学意义。抑制素B、血清AMH、性激素三种联合检测的特异度明显高于单独检测。结论：抑制素B、抗苗勒管激素(AMH)、性激素三者联合检测对PCOS诊断有较高的应用价值。

Abstract: Objective: To explore the application of inhibin B combined with AMH and sex hormones in the diagnosis of polycystic ovary syndrome (PCOS). Methods: A retrospective analysis was conducted, selecting 50 PCOS patients who visited Liuzhou Hospital of Guangzhou Women and Children’s Medical Center from June 2022 to June 2023 as the experimental group, and 50 normal examinees during the same period as the control group. All participants underwent fasting blood tests to measure inhibin B, anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and testosterone (T). The serum levels of INHB, AMH, and sex hormone indicators in the experimental group were analyzed and compared with those in the control group using statistical methods such as the one-sample Kolmogorov-Smirnov test, independent sample T-test, and logistic regression analysis. Results: The levels of E2, FSH, and INHB in the PCOS group were higher than those in the control group, P > 0.05. The levels of AMH, T, and LH activity in the PCOS group were higher than those in the control group, P < 0.05, indicating statistical significance. The specificity of the combined detection of inhibin B, serum AMH, and sex hormones was significantly higher than that of individual tests. Conclusion: The combined detection of inhibin B, anti-Müllerian hormone (AMH), and sex hormones has high application value in the diagnosis of PCOS.