一例宫颈浸润性复层产黏液癌并文献复习
One Case of Invasive Stratified Mucin-Producing Carcinoma and Literature Review
DOI: 10.12677/acm.2025.1572067, PDF,    科研立项经费支持
作者: 鄢 祺, 汪小莉, 陈 兰, 张 燕*:西南医科大学附属中医医院,肿瘤·血液病科,四川 泸州
关键词: 宫颈浸润性复层产黏液癌诊断治疗Invasive Stratified Mucin-Producing Carcinoma Diagnosis Treatment
摘要: 宫颈浸润性复层产黏液癌(Invasive stratified mucin-producing carcinoma, ISMC)是新近发现的具有独特组织病理学特点的宫颈浸润性腺癌的罕见类型,其早期复发及远处转移风险高,预后差。由于国内外文献报道较少,临床医师对其认识尚不充分,可能增加该病诊治的难度,本文通过回顾分析我科收治的1例中晚期宫颈浸润性复层产黏液癌的临床诊治过程及预后,并结合最新文献分析总结,以提高对该病的认识水平。
Abstract: Invasive stratified mucin-producing carcinoma (ISMC) is a rare type of invasive adenocarcinoma of the cervix with unique histopathological features, which has a high risk of early recurrence and distant metastasis, and has a poor prognosis. Due to the lack of literature reports at home and abroad, clinicians still do not fully understand it, which may increase the difficulty of diagnosis and treatment of this disease, this article reviews and analyzes the clinical diagnosis and treatment process and prognosis of one case of mid-to-advanced cervical invasive stratified mucin-producing carcinoma admitted to our department, and summarizes it in combination with the latest literature analysis to improve the level of understanding of this disease.
文章引用:鄢祺, 汪小莉, 陈兰, 张燕. 一例宫颈浸润性复层产黏液癌并文献复习[J]. 临床医学进展, 2025, 15(7): 873-878. https://doi.org/10.12677/acm.2025.1572067

参考文献

[1] Lastra, R.R., Park, K.J. and Schoolmeester, J.K. (2016) Invasive Stratified Mucin-Producing Carcinoma and Stratified Mucin-Producing Intraepithelial Lesion (SMILE): 15 Cases Presenting a Spectrum of Cervical Neoplasia with Description of a Distinctive Variant of Invasive Adenocarcinoma. American Journal of Surgical Pathology, 40, 262-269. [Google Scholar] [CrossRef] [PubMed]
[2] Parra-Herran, C., Kong, C.S., Alvarado-Cabrero, I., et al. (2020) WHO Classification of Tumours of Female Reproductive Organs. 5th Edition, IARC Press, 369.
[3] Hodgson, A., Olkhov-Mitsel, E., Howitt, B.E., Nucci, M.R. and Parra-Herran, C. (2019) International Endocervical Adenocarcinoma Criteria and Classification (IECC): Correlation with Adverse Clinicopathological Features and Patient Outcome. Journal of Clinical Pathology, 72, 347-353. [Google Scholar] [CrossRef] [PubMed]
[4] Turashvili, G. and Park, K.J. (2019) Cervical Glandular Neoplasia: Classification and Staging. Surgical Pathology Clinics, 12, 281-313. [Google Scholar] [CrossRef] [PubMed]
[5] Liu, A., Yang, M., Zou, H., et al. (2025) Cytological Features of Invasive Stratified Mucin-Producing Carcinoma of the Uterine Cervix and Literature Review. Discover Oncology, 16, 990. [Google Scholar] [CrossRef] [PubMed]
[6] Stolnicu, S., Segura, S., Parra-Herran, C., Horn, L., Hoang, L., Terinte, C., et al. (2020) Invasive Stratified Mucin-Producing Carcinoma (ISMC) of the Cervix: A Study on Morphologic Diversity. American Journal of Surgical Pathology, 44, 873-880. [Google Scholar] [CrossRef] [PubMed]
[7] Lin, T., Wang, W., Xu, L. and He, Y. (2022) Invasive Stratified Mucin-Producing Carcinoma (ISMC) of Uterine Cervix: Description of Pathological Findings and Prognosis Factors in a Series of 15 Chinese Patients. Archives of Gynecology and Obstetrics, 306, 1703-1709. [Google Scholar] [CrossRef] [PubMed]
[8] Park, E., Kim, Y.T., Kim, S., Nam, E.J. and Cho, N.H. (2021) Immunohistochemical and Genetic Characteristics of HPV-Associated Endocervical Carcinoma with an Invasive Stratified Mucin-Producing Carcinoma (ISMC) Component. Modern Pathology, 34, 1738-1749. [Google Scholar] [CrossRef] [PubMed]
[9] Wu, X., Sun, Y., Yang, H., et al. (2024) Cadonilimab plus Platinum-Based Chemotherapy with or without Bevacizumab as First-Line Treatment for Persistent, Recurrent, or Metastatic Cervical Cancer (COMPASSION-16): A Randomised, Double-Blind, Place-Bo-Controlled Phase 3 Trial in China. The Lancet, 404, 1668-1676.
[10] Yao, Y., Wang, Y., Ye, L., Lu, B. and Lu, W. (2023) Invasive Stratified Mucin‐producing Carcinoma (ISMC) of the Cervix: A Clinicopathological and Molecular Analysis of 59 Cases with Special Emphasis on Histogenesis and Potential Therapeutic Targets. Histopathology, 84, 315-324. [Google Scholar] [CrossRef] [PubMed]
[11] 唐丹, 付萍, 赵连花. 宫颈浸润性复层产黏液性癌18例HER2扩增与PD-L1表达[J]. 中华病理学杂志, 2024, 53(10): 1018-1023.
[12] Choi, S., Kim, S. and Kim, H. (2021) Invasive Stratified Mucin-Producing Carcinoma (ISMC) of the Uterine Cervix: Clinicopathological and Molecular Characteristics with Special Emphasis on the First Description of Consistent Programmed Death-Ligand 1 (PD-L1) Over-Expression. Cancer GenomicsProteomics, 18, 685-698. [Google Scholar] [CrossRef] [PubMed]
[13] Zhao, X., Qin, Y., Shen, X., et al. (2020) The Coexistence of Invasive Stratified Mucin-Producing Carcinoma, Mucinous Carcinoma and Non-Specific Type and Squamous Cell Carcinoma of the Uterine Cervix: A Case Report. International Journal of Clinical and Experimental Pathology, 13, 2187-2191.
[14] 陈勇, 张和平, 赵彩霞, 等. 子宫颈浸润性复层产黏液癌1例[J]. 诊断病理学杂志, 2023, 30(5): 510+514.
[15] 李洋, 彭祺祺, 赵晔, 等. 宫颈浸润性复层产黏液性癌一例并文献复习[J]. 妇产与遗传(电子版), 2022, 12(4): 52-55.
[16] 孙国敏, 张琴琴, 巫永志, 等. 宫颈浸润性复层产黏液性癌1例临床病理分析及文献复习[J]. 皖南医学院学报, 2022, 41(1): 100-102.
[17] 李君, 刘莎. 宫颈浸润性复层产黏液性癌1例临床病理分析[J]. 医学理论与实践, 2024, 37(2): 359-360+356.
[18] 蔡小芬, 方庆全, 叶美华. 含有浸润性复层产黏液性癌成分宫颈癌的临床病理特征[J]. 实用医技杂志, 2024, 31(12): 880-883+914.
[19] 杨文婷, 陈芳, 韩靖, 等. 宫颈浸润性复层产黏液性癌的临床病理学特征并文献复习[J]. 诊断病理学杂志, 2023, 30(2): 166-170.
[20] 陈雪, 曾郁, 毕小涵, 等. 宫颈浸润性复层产黏液性癌3例临床病理分析并文献复习[J]. 外科研究与新技术(中英文), 2024, 13(1): 39-43.
[21] 王方平, 汪静, 陈宗科. 宫颈浸润性复层产黏液的癌8例临床病理学分析[J]. 诊断病理学杂志, 2021, 28(8): 666-670.
[22] 吴倩文, 阳琼芝, 肖诗维, 等. 子宫颈浸润性复层产黏液的癌临床与病理分析(附12例) [J]. 现代肿瘤医学, 2024, 32(3): 535-540.
[23] 杨小芳, 于大海, 黄腾, 等. 子宫颈浸润性复层产黏液性癌诊疗分析及文献回顾[J]. 中国实用妇科与产科杂志, 2022, 38(2): 254-256.
[24] 陈利杰, 张森, 吴文清, 等. 子宫颈浸润性复层产黏液的癌22例临床病理分析[J]. 临床与实验病理学杂志, 2022, 38(11): 1324-1329.
[25] 赵连花, 马强, 付萍, 等. 子宫颈浸润性复层产黏液性癌1例并文献复习[J]. 临床与实验病理学杂志, 2019, 35(9): 1085-1087.
[26] 张冬梅, 魏建国, 赵芳, 等. 子宫颈浸润性复层产黏液的癌1例[J]. 临床与实验病理学杂志, 2020, 36(2): 240-241.
[27] 张银川, 崔竹梅, 殷广洁. 子宫颈浸润性产黏液性癌1例并文献复习[J]. 临床医学进展, 2025, 15(3): 12-16.
[28] 刘玉婷, 闫婧, 赵雪莼, 等. 宫颈浸润性复层产黏液的癌1例并文献复习[J]. 饮食保健, 2025(10): 4-6.
[29] 李海凤, 林维真, 周璐, 等. 子宫颈浸润性复层产黏液性癌临床病理分析[J]. 新医学, 2020, 51(11): 850-855.
[30] 苏雪, 杜红雁, 郭祎男, 等. 宫颈产黏液的复层上皮肿瘤性病变临床病理学特征并文献复习[J]. 诊断病理学杂志, 2022, 29(2): 114-117, 122.
[31] 向丽萍, 袁静萍, 吴小艳, 等. 子宫颈浸润性复层产黏液的癌2例[J]. 临床与实验病理学杂志, 2022, 38(11): 1402-1403.
[32] 周冬梅, 林丽燕. 子宫颈浸润性复层产黏液的癌6例临床病理分析[J]. 临床与实验病理学杂志, 2022, 38(1): 36-39, 45.
[33] 张睿, 林艳丽, 田晓琴, 等. 子宫颈浸润性复层产黏液癌4例临床病理分析[J]. 临床与实验病理学杂志, 2022, 38(11): 1384-1387.
[34] 孟苹, 徐佳佳, 王国庆, 等. 宫颈复层产黏液性癌5例临床病理分析[J]. 诊断病理学杂志, 2020, 27(6): 381-384.
[35] 刘雅玲, 黄献, 王菲, 等. 宫颈产生黏液复层上皮肿瘤性病变的临床组织及分子病理特征[J]. 中国肿瘤生物治疗杂志, 2025, 32(3): 301-308.
[36] 徐红, 王映梅, 张静. 宫颈产生黏液的复层上皮肿瘤性病变临床病理学特征[J]. 中华病理学杂志, 2020, 49(1): 28-33
[37] 于丽丽, 赵明, 陈万远, 等. 子宫颈浸润性复层产黏液的癌一例[J]. 中华病理学杂志, 2017, 46(11): 795-796
[38] 徐艳娟, 林娜, 陈少华, 等. 宫颈浸润性复层产黏液的癌临床病理分析[J]. 中国医师杂志, 2020, 22(12): 1870-1873
[39] 李厚强, 庞宇, 孙欢, 等. 宫颈浸润性复层产黏液癌临床病理学特征及其程序性细胞死亡配体1表达状态研究[J]. 中华转移性肿瘤杂志, 2023, 6(4): 385-393
[40] Lei, R. (2019) Invasive Stratified Mucin-Producing Carcinoma: A Clinicopathological Analysis of Three Cases. Cancer Biology & Therapy, 20, 1403-1407. [Google Scholar] [CrossRef] [PubMed]
[41] Onishi, J., Sato, Y., Sawaguchi, A., Yamashita, A., Maekawa, K., Sameshima, H., et al. (2016) Stratified Mucin-Producing Intraepithelial Lesion with Invasive Carcinoma: 12 Cases with Immunohistochemical and Ultrastructural Findings. Human Pathology, 55, 174-181. [Google Scholar] [CrossRef] [PubMed]
[42] Horn, L., Handzel, R., Borte, G., Siebolts, U., Haak, A. and Brambs, C.E. (2019) Invasive Stratified Mucin-Producing Carcinoma (i-Smile) of the Uterine Cervix: Report of a Case Series and Review of the Literature Indicating Poor Prognostic Subtype of Cervical Adenocarcinoma. Journal of Cancer Research and Clinical Oncology, 145, 2573-2582. [Google Scholar] [CrossRef] [PubMed]