强迫症的脑结构损伤网络定位研究

Study on the Brain Structural Damage Network Localization of Obsessive-Compulsive Disorder

摘要: 目的：采用功能连接网络映射(FCNM)方法，分析强迫症患者脑结构拓扑异常，揭示其潜在神经病理生理机制。材料与方法：依据PRISMA指南，系统性筛选30篇静息态功能磁共振成像研究(含33组对比数据，1148例患者、1330名健康对照)，提取核心指标并通过FCNM构建静息态异常功能网络。结果：强迫症灰质体积损伤网络主要包括额下回和额中回、梭状回、岛叶、尾状核、壳核和丘脑，关于经典的脑网络主要涉及额顶控制网络。结论：我们的研究整合了先前强迫症研究中不一致的发现，为强迫症神经病理学提供了一种基于网络的视角。这可能会增强未来的神经调节治疗方法，并有助于制定有效的、有针对性的强迫症预防策略。

Abstract: Objective: To analyze the abnormal brain structure and topology in patients with obsessive-compulsive disorder (OCD) by using the method of functional connectivity network mapping (FCNM), and to reveal its potential neuropathophysiological mechanism. Materials and Methods: According to PRISMA guidelines, 30 resting functional magnetic resonance imaging studies (including 33 groups of comparative data, 1148 patients and 1330 healthy controls) were systematically screened, and the core indicators were extracted and the resting abnormal functional network was constructed through FCNM. Results: Obsessive-compulsive disorder gray matter volume injury network mainly includes inferior frontal gyrus and middle frontal gyrus, fusiform gyrus, insula, caudate nucleus, putamen and thalamus, and the classical brain network mainly involves frontoparietal control network. Conclusion: Our study integrates the inconsistent findings in previous studies on obsessive-compulsive disorder and provides a network-based perspective for neuropathology of obsessive-compulsive disorder. This may strengthen the future neuromodulation therapy and help to formulate effective and targeted prevention strategies for obsessive-compulsive disorder.