IVF合并DOCK基因变异，羊水过少，胎儿生长受限的重症监护一例报告

A Case Report to IVF with DOCK Gene Mutations, Oligohydramnios, and Fetal Growth Restriction in Intensive Care

摘要: 体外受精技术成熟，全球广泛应用，但多胎妊娠、卵巢过度刺激等风险仍存在，DOCK基因的研究处于早期阶段，病例数据较少。本文报导并讨论一例IVF合并DOCK基因变异、羊水过少、胎儿生长受限的孕妇的妊娠监督及其终止妊娠时机，方法的选择。一名停经30 + 5周孕妇，因下腹部发紧13小时余入院，试管婴儿妊娠状态合并胎儿生长发育迟缓、羊水过少、完全性前置胎盘、胎盘血窦、胎盘植入不伴出血？羊水穿刺医学外显子检测(父母子)发现：DOCK基因变异，经保胎治疗至36 + 1周，介入下行子宫下段剖宫产术，产后大出血，予输血止血治疗，胎儿送至新生儿科治疗，术后恢复可，出院，本例复合多种病症，复杂且严重，其妊娠监督注意事项，终止妊娠方式和时机的选择为复杂高危妊娠的治疗提供了新证据。

Abstract: It is mature for the in vitro fertilization technology, which is widely used worldwide. However, there is a risk in the existence of multiple pregnancy and ovarian hyperstimulation. The research on the DOCK gene is in the early stage, and there are few case data. Report and discussion have been carried out in this study, which is to attain a selection of the pregnancy supervision of a pregnant woman with IVF combined with DOCK gene variants, oligohydramnios, and fetal growth restriction, likewise the timing and pregnancy termination. A pregnant woman who had stopped menstruation for 30 plus 5 weeks was hospitalized due to tightness in the lower abdomen for more than 13 hours, and the IVF pregnancy status was combined with fetal growth retardation, oligohydramnios, complete placenta previa, placental blood sinus, and placenta implantation without bleeding? It was found that the pregnant woman can be discharged after fetal protection treatment to 36 plus 1 weeks, by the interventional lower uterine cesarean section, postpartum hemorrhage, blood transfusion to stop bleeding, fetus sent to neonatology for treatment, and reaching postoperative recovery through amniocentesis medical exome detection (parent-child). New evidence has been provided for the treatment of complex high-risk pregnancies with the precautions for pregnancy supervision, and the selection of pregnancy termination mode and timing, in this complex and severe combination of multiple diseases case.