儿童自闭症谱系障碍与空气污染物关联性的研究进展
Research Progress on the Association between Childhood Autism Spectrum Disorder and Air Pollutants
DOI: 10.12677/acm.2025.1572099, PDF,   
作者: 邱荷语：重庆医科大学公共卫生学院，重庆；重庆医科大学附属大足医院(重庆市大足区人民医院)，重庆；袁跃勇*：重庆医科大学附属大足医院(重庆市大足区人民医院)，重庆
关键词: 自闭症谱系障碍；空气污染；颗粒物；相关性；机制；Autism Spectrum Disorder； Air Pollution； Particulate Matter； Correlation； Mechanism
摘要: 在全球范围内，自闭症谱系障碍(ASD)患儿的数量正以惊人的速度增长，发病率明显增加，遗传和环境因素都会促进ASD的发展。近年来，关于环境污染物与ASD发病之间的关系逐渐引起了广泛关注。现有的大量证据表明，围产期暴露于环境污染物对儿童ASD的发病影响最大，而空气污染应被视为其发病的危险因素之一。本文回顾了空气污染物与ASD发病关系的研究成果，并对其流行病学和发病机制的分子途径分别进行论述，以便对ASD有更加深入的了解，并提供新的研究思路。
Abstract: Globally, the number of children with autism spectrum disorder (ASD) is increasing at an astonishing rate, and the incidence rate is significantly rising. Both genetic and environmental factors can promote the development of ASD. In recent years, the relationship between environmental pollutants and the incidence of ASD has gradually attracted widespread attention. A large amount of existing evidence indicates that perinatal exposure to environmental pollutants has the greatest impact on the onset of ASD in children, and air pollution should be regarded as one of the risk factors for its onset. This article reviews the research results on the relationship between air pollutants and the pathogenesis of ASD, and discusses the molecular pathways of its epidemiology and pathogenesis respectively, in order to have a deeper understanding of ASD and provide new research ideas.
文章引用：邱荷语, 袁跃勇. 儿童自闭症谱系障碍与空气污染物关联性的研究进展[J]. 临床医学进展, 2025, 15(7): 1107-1116. https://doi.org/10.12677/acm.2025.1572099

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