中医外治法促进腹部疾病术后胃肠功能恢复的研究进展
Research Progress on the Promotion of Gastrointestinal Function Recovery after Abdominal Surgery by Traditional Chinese Medicine External Therapies
DOI: 10.12677/tcm.2025.147452, PDF,    科研立项经费支持
作者: 张 政, 郭 徽, 颜士朝:广西中医药大学第一临床医学院,广西 南宁;陈芳芳*, 许 斌:广西中医药大学第一附属医院胃肠肛门外科,广西 南宁
关键词: 胃肠功能障碍发病机制中医外治研究进展Gastrointestinal Dysfunction Pathogenesis External Treatment of Traditional Chinese Medicine Research Progress
摘要: 腹部疾病术后胃肠功能障碍(POGD)是继发于手术后的一种胃肠道急性病理生理改变,以胃肠道黏膜损害、屏障功能破坏以及胃肠道运动障碍为主要特征。术后大多数患者出现腹胀腹痛、恶心呕吐、排气排便时间延长等症状,POGD患者住院时间更长,住院费用增加,常出现肠梗阻、感染、电解质紊乱等并发症,例如,严重者可导致消化道瘘、严重感染、多器官功能障碍综合征甚至死亡等并发症。深入研究POGD的发病机制并积极寻找有效治疗方法对患者术后恢复具有深刻的意义。POGD一般分为3个阶段,即外科损伤阶段、炎症反应阶段和修复阶段。发病机制尚未完全明确,西医治疗手段单一,临床效果欠佳。而传统的中医外治法治疗术后胃肠动力障碍疾病有独特优势,中医外治法中的针灸、中药灌肠、艾灸、耳穴疗法等为术后POGD的治疗提供了新的治疗手段。文章就腹部疾病术后胃肠功能障碍的病因、发病机制以及中医外治法促进腹部疾病术后胃肠功能恢复的相关研究成果进行综述。
Abstract: Postoperative gastrointestinal dysfunction (POGD) in abdominal diseases is an acute pathophysiological change in the gastrointestinal tract secondary to surgery, characterized by gastrointestinal mucosal damage, barrier function disruption, and gastrointestinal motility disorders. After surgery, most patients experience symptoms such as abdominal distension, abdominal pain, nausea and vomiting, prolonged gas and bowel movements, and prolonged hospitalization. POGD patients have longer hospital stays and increased hospital costs, and often experience complications such as intestinal obstruction, infection, electrolyte imbalance, and other complications. For example, severe cases can lead to complications such as digestive tract fistula, severe infection, multiple organ dysfunction syndrome, and even death. In-depth study of the pathogenesis of POGD and active search for effective treatment methods have profound significance for patients’ postoperative recovery. POGD is generally divided into three stages: surgical injury stage, inflammatory response stage, and repair stage. The pathogenesis is not fully understood, and the treatment methods of Western medicine are single, with poor clinical effects. External treatment methods of traditional Chinese medicine have unique advantages in treating postoperative gastrointestinal motility disorders. Acupuncture and moxibustion, traditional Chinese medicine enema, moxibustion, auricular therapy, and other external treatment methods of TCM provide new treatment options for the treatment of postoperative POGD. This article reviews the causes and pathogenesis of gastrointestinal dysfunction after abdominal surgery, as well as the relevant research results of external treatment methods of traditional Chinese medicine to promote the recovery of gastrointestinal function after abdominal surgery.
文章引用:张政, 陈芳芳, 许斌, 郭徽, 颜士朝. 中医外治法促进腹部疾病术后胃肠功能恢复的研究进展[J]. 中医学, 2025, 14(7): 3064-3072. https://doi.org/10.12677/tcm.2025.147452

参考文献

[1] Hedrick, T.L., McEvoy, M.D., Mythen, M.G., Bergamaschi, R., Gupta, R., Holubar, S.D., et al. (2018) American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Postoperative Gastrointestinal Dysfunction within an Enhanced Recovery Pathway for Elective Colorectal Surgery. Anesthesia & Analgesia, 126, 1896-1907. [Google Scholar] [CrossRef] [PubMed]
[2] 付同, 李娟. 经皮穴位电刺激改善术后胃肠功能紊乱的机制和临床应用进展[J]. 临床麻醉学杂志, 2023, 39(5): 528-531.
[3] Lu, Y., Fang, P., Yu, Y., Cheng, X., Feng, X., Wong, G.T.C., et al. (2021) Effect of Intraoperative Dexmedetomidine on Recovery of Gastrointestinal Function after Abdominal Surgery in Older Adults: A Randomized Clinical Trial. JAMA Network Open, 4, e2128886. [Google Scholar] [CrossRef] [PubMed]
[4] Zhang, Y., Wang, Z., Basharat, Z., Hu, M., Hong, W. and Chen, X. (2022) Nomogram of Intra-Abdominal Infection after Surgery in Patients with Gastric Cancer: A Retrospective Study. Frontiers in Oncology, 12, Article 982807. [Google Scholar] [CrossRef] [PubMed]
[5] Pang, R.H., Zhu, Y.Q., Wu, J., et al. (2022) Effect of Electroacupuncture on Gastrointestinal Function of Patients after Laparoscopic Cholecystectomy under General Anesthesia. Acupuncture Research, 47, 640-643.
[6] Potapov, A.L. (2008) Systemic Inflammatory Response Syndrome and Anti-Endotoxin Immunity after the Operations on the Abdominal Cavity Organs. Klin Khir, No. 1, 22-24.
[7] 张晓, 余先昊. 腹腔镜结直肠癌根治术对老年结直肠癌患者术后胃肠功能恢复的影响[J]. 中国老年学杂志, 2021, 41(11): 2283-2286.
[8] 袁春辉, 傅燕媚, 陈锦铭, 等. 腹腔镜与开腹胆囊切除术对急性结石性胆囊炎患者胃肠功能的影响[J]. 中国医药科学, 2019, 9(7): 239-241.
[9] 吴波. 腹腔镜与开腹胃癌根治术治疗进展期胃癌的临床对比研究[J]. 中国实用医药, 2023, 18(11): 56-58.
[10] Mosińska, P., Zielińska, M. and Fichna, J. (2016) Expression and Physiology of Opioid Receptors in the Gastrointestinal Tract. Current Opinion in Endocrinology, Diabetes & Obesity, 23, 3-10. [Google Scholar] [CrossRef] [PubMed]
[11] Galligan, J.J. and Akbarali, H.I. (2014) Molecular Physiology of Enteric Opioid Receptors. American Journal of Gastroenterology, 2, 17-21.
[12] Deflers, H., Gandar, F., Bolen, G., Detilleux, J., Sandersen, C. and Marlier, D. (2022) Effects of a Single Opioid Dose on Gastrointestinal Motility in Rabbits (Oryctolagus cuniculus): Comparisons among Morphine, Butorphanol, and Tramadol. Veterinary Sciences, 9, Article 28. [Google Scholar] [CrossRef] [PubMed]
[13] 马垚, 朱永康. 术后胃肠功能障碍机制研究进展[J]. 辽宁中医药大学学报, 2011, 13(7): 236-238.
[14] Bain, C.C. and Schridde, A. (2018) Origin, Differentiation, and Function of Intestinal Macrophages. Frontiers in Immunology, 9, Article 2733. [Google Scholar] [CrossRef] [PubMed]
[15] 武娟, 孙雪莲, 李力卓. 急诊多发伤患者急性胃肠功能损伤的影响因素及相关防治措施[J]. 临床急诊杂志, 2021, 22(12): 814-819.
[16] Chen, Y., Dong, C., Lian, G., Li, D., Yin, Y., Yu, W., et al. (2020) Dexamethasone on Postoperative Gastrointestinal Motility: A Placebo‐Controlled, Double‐Blinded, Randomized Controlled Trial. Journal of Gastroenterology and Hepatology, 35, 1549-1554. [Google Scholar] [CrossRef] [PubMed]
[17] Mueller, T., Kehl, V., Egert-Schwender, S., Friess, H., Novotny, A. and Reim, D. (2022) Peritoneal Antiseptic Irrigation to Prevent Surgical Site Infection after Laparotomy for Hepatobiliary or Gastrointestinal Surgery (PAISI)—Protocol for a Randomized Controlled Study. Trials, 23, Article No. 1029. [Google Scholar] [CrossRef] [PubMed]
[18] Delvalle, N.M., Dharshika, C., Morales-Soto, W., Fried, D.E., Gaudette, L. and Gulbransen, B.D. (2018) Communication between Enteric Neurons, Glia, and Nociceptors Underlies the Effects of Tachykinins on Neuroinflammation. Cellular and Molecular Gastroenterology and Hepatology, 6, 321-344. [Google Scholar] [CrossRef] [PubMed]
[19] Li, Z., Hao, M.M., Van den Haute, C., Baekelandt, V., Boesmans, W. and Vanden Berghe, P. (2019) Regional Complexity in Enteric Neuron Wiring Reflects Diversity of Motility Patterns in the Mouse Large Intestine. eLife, 8, e42914. [Google Scholar] [CrossRef] [PubMed]
[20] Sinz, S., Warschkow, R., Tarantino, I. and Steffen, T. (2023) Gum Chewing and Coffee Consumption but Not Caffeine Intake Improve Bowel Function after Gastrointestinal Surgery: A Systematic Review and Network Meta-Analysis. Journal of Gastrointestinal Surgery, 27, 1730-1745. [Google Scholar] [CrossRef] [PubMed]
[21] Watkins, E.L., Schellack, N., Abraham, V. and Bebington, B. (2021) Men and Those with a History of Smoking Are Associated with the Development of Postoperative Ileus Following Elective Colorectal Cancer Resection at a Private Academic Hospital in Johannesburg, South Africa: A Retrospective Cohort Study. Frontiers in Surgery, 8, Article 667124. [Google Scholar] [CrossRef] [PubMed]
[22] 李情琴. 补中益气丸联合肠内营养治疗危重症患者胃肠功能障碍临床观察[J]. 光明中医, 2020, 35(6): 902-904.
[23] 朱惠玲. 胃肠道肿瘤患者术后胃肠功能恢复的影响因素分析[J]. 护理实践与研究, 2021, 18(24): 3649-3652.
[24] Ahmad, A., Faridi, S., Siddiqui, F., Edhi, M.M. and Khan, M. (2015) Effect of Bupivacaine Soaked Gauze in Postoperative Pain Relief in Laparoscopic Cholecystectomy: A Prospective Observational Controlled Trial in 120 Patients. Patient Safety in Surgery, 9, Article No. 31. [Google Scholar] [CrossRef] [PubMed]
[25] Wu, F., Liu, W., Feng, H., Long, L., Hou, L. and Hou, C. (2020) Application of Traditional Chinese Medicines in Postoperative Abdominal Adhesion. Evidence-Based Complementary and Alternative Medicine, 2020, Article 8073467. [Google Scholar] [CrossRef] [PubMed]
[26] Shah, S., Godhardt, L. and Spofford, C. (2022) Acupuncture and Postoperative Pain Reduction. Current Pain and Headache Reports, 26, 453-458. [Google Scholar] [CrossRef] [PubMed]
[27] 陈浩然, 方霜霜, 林新锋. 足三里穴位注射治疗术后胃肠功能障碍疗效与安全性的Meta分析[J]. 广州中医药大学学报, 2022, 39(10): 2450-2458.
[28] Zhang, W., Zhang, H., Wang, S., Guo, J., Ma, Y., Li, Y., et al. (2022) Perioperative Acupuncture Optimizes Surgical Outcomes: Theory, Clinical Practice and Future Perspectives. The American Journal of Chinese Medicine, 50, 961-978. [Google Scholar] [CrossRef] [PubMed]
[29] Jung, S.Y., Chae, H.D., Kang, U.R., Kwak, M.A. and Kim, I.H. (2017) Effect of Acupuncture on Postoperative Ileus after Distal Gastrectomy for Gastric Cancer. Journal of Gastric Cancer, 17, 11-20. [Google Scholar] [CrossRef] [PubMed]
[30] Lili, H., Lei, X., Yan, S. and Fen, G. (2016) Effect of Electric Acupoint Stimulation on Gastrointestinal Hormones and Motility among Geriatric Postoperative Patients with Gastrointestinal Tumors. Journal of Traditional Chinese Medicine, 36, 450-455. [Google Scholar] [CrossRef] [PubMed]
[31] 杨书恒, 黄平. 腹腔镜胆囊切除术后疼痛的防治方法[J]. 川北医学院学报, 2016, 31(5): 777-780.
[32] 刘琤琤, 吴莉, 李敏, 等. 辰时中药足浴联合艾灸足三里对腹腔镜胆囊切除患者术后胃肠功能的影响[J]. 护理学报, 2017, 24(15): 60-63.
[33] 卞吉雯. 脐灸对胆热脾寒型胆囊炎腹腔镜胆囊切除术后患者胃肠功能恢复的临床研究[D]: [硕士学位论文]. 济南: 山东中医药大学, 2022.
[34] 刘雨儿. 艾灸足三里对功能性消化不良大鼠胃肠动力及MTL、CCK的影响[D]: [硕士学位论文]. 长沙: 湖南中医药大学, 2015.
[35] 冯文涛, 韩耀国, 孙芳园, 等. 中药灌肠法的临床应用研究进展[J]. 世界中西医结合杂志, 2020, 15(8): 1565-1568.
[36] 朱梅, 胡晖, 张娱, 等. 大黄灌肠液对LC术后患者保留灌肠的护理探讨[J]. 中国社区医师, 2021, 37(13): 174-175.
[37] 肖思滇. 子午流注法中药灌肠对肝胆湿热型急性胆囊炎腹腔镜术后胃肠功能的影响[J]. 中国中医药现代远程教育, 2020, 18(21): 83-85.
[38] 陈敏捷, 许云帆, 曹扶胜, 等. 小承气汤保留灌肠对胃癌术后胃肠功能恢复的影响[J]. 湖北中医药大学学报, 2018, 20(3): 60-62.
[39] 刘锐, 田勇, 付国川, 等. 基于通腑视角探讨肠镜术后腹胀外治法的研究进展[J]. 中医临床研究, 2023, 15(27): 117-120.
[40] 张睿, 国丽群, 唐云跃, 等. 耳穴贴压对胃癌病人术后胃肠功能恢复影响的Meta分析[J]. 循证护理, 2021, 7(3): 293-301.
[41] 孙龙, 李菊云, 段培蓓, 等. 不同时间点耳穴贴压对胃癌患者术后胃肠功能恢复的作用[J]. 中华护理杂志, 2015, 50(7): 844-847.
[42] 邵安民, 费建平, 胡菲娅, 等. 耳穴贴压对腹腔镜胆囊切除患者胃肠功能的影响[J]. 中医学报, 2016, 31(12): 2029-2032.