补肾护骨胶囊治疗骨质疏松症的临床经验及机制探讨

Clinical Experience and Mechanism of Bushen Hugu Capsule in Treating Osteoporosis

摘要: 目的：探讨补肾护骨胶囊治疗骨质疏松症(OP)的临床疗效及潜在作用机制。方法：通过分析典型医案，结合中医理论及现代药理学研究，系统阐述补肾护骨胶囊的组方原理及临床应用。结果：65岁女性OP患者经补肾护骨胶囊治疗4周后，腰背疼痛VAS评分降低40%，骨代谢指标(β-CTX, P1NP)显著改善(P < 0.05)。方中淫羊藿、紫河车等药物可能通过调控RAGE/NF-κB信号通路抑制骨吸收。结论：补肾护骨胶囊通过多靶点、多通路发挥抗骨质疏松作用，体现中医“肾主骨”理论的科学内涵。

Abstract: Objective: To explore the clinical efficacy and potential mechanism of action of Bushen Hugu Capsule in the treatment of osteoporosis (OP). Method: By analyzing typical medical cases, combined with traditional Chinese medicine theory and modern pharmacological research, the formula principle and clinical application of Bushen Hugu Capsule were systematically expounded. Result: After a 65-year-old female OP patient was treated with Bushen Hugu Capsule for 4 weeks, the VAS score of low back pain decreased by 40%, and the bone metabolism indicators (β-CTX, P1NP) were significantly improved (P < 0.05). Drugs such as Epimedium and Zihexia in the formula may inhibit bone resorption by regulating the RAGE/NF-κB signaling pathway. Conclusion: Bushen Hugu Capsules exert anti-osteoporosis effects through multiple targets and pathways, embodying the scientific connotation of the theory in traditional Chinese medicine that “the kidney governs the bones”.