胰腺异位肝细胞癌一例及文献复习
A Case of Hepatocellular Carcinoma in the Pancreas and Literature Review
摘要: 探究胰腺异位肝细胞癌的病理学特征，回顾性分析1例胰尾部异位肝细胞癌的病理学特征及免疫组织化学，并复习相关文献。患者男性56岁，因胰腺炎入院，乙肝丙肝相关标记物阴性，肿瘤标志物未升高。腹部MRI显示胰尾部有一肿物，最大径3.5 cm。免疫组化显示肿瘤组织HerPar-1大部分阳性、Ki67散在阳性、GS阳性、CEA散在阳性、CD10阳性、HSP70小灶状阳性、CK (AE1/AE3)阳性，EMA、CK7、CK19、CK20、Vimentin、Arginase-1、AFP、Glypican-3、TTF-1、Syn、INSM-1均阴性，结合相关病史及免疫组化结果支持胰腺异位肝细胞癌的诊断，随访三个月患者恢复良好。
Abstract: To explore the pathological characteristics of ectopic hepatocellular carcinoma in the pancreas, a case of hepatocellular carcinoma in the tail of the pancreas was retrospectively analyzed for its pathological features and immunohistochemistry, and relevant literature was reviewed. The patient was a 56-year-old male who was admitted to the hospital due to pancreatitis. The markers for hepatitis B and C were negative, and the tumor markers were not elevated. Abdominal MRI showed a mass in the tail of the pancreas with a maximum diameter of 3.5 cm. Immunohistochemistry showed that the tumor tissue was mostly positive for HerPar-1, scattered positive for Ki67, positive for GS, scattered positive for CEA, positive for CD10, focal positive for HSP70, and positive for CK (AE1/AE3). EMA, CK7, CK19, CK20, Vimentin, Arginase-1, AFP, Glypican-3, TTF-1, Syn, and INSM-1 were all negative. The diagnosis of ectopic hepatocellular carcinoma in the pancreas was supported by the relevant medical history and immunohistochemical results. The patient was followed up for three months and recovered well.
文章引用：郭峰有, 张继红. 胰腺异位肝细胞癌一例及文献复习[J]. 临床医学进展, 2025, 15(7): 1199-1204. https://doi.org/10.12677/acm.2025.1572112

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