骨科手术中BCIS预防和处理的研究进展
Research Progress on the Prevention and Management of BCIS in Orthopedic Surgery
DOI: 10.12677/acm.2025.1572119, PDF,   
作者: 贾迎奥, 陈梦飞, 梁嘉文:延安大学医学院,陕西 延安;王 飞*:延安大学附属医院骨科,陕西 延安
关键词: 骨水泥植入综合征关节置换术骨科手术Bone Cement Implantation Syndrome Arthroplasty Orthopedics Surgery
摘要: 骨水泥植入综合征(BCIS)是涉及加压骨水泥的骨科手术中公认的且可能致命的并发症,该综合征主要见于骨水泥型关节置换术中。骨水泥型关节置换术作为骨科常用且有效的治疗手段,在临床应用广泛。然而,值得注意的是,关节置换术中使用骨水泥可能会引发骨水泥植入综合征(BCIS),如手术中不能正确识别及处理该综合征可能会导致患者缺氧、全身性低血压、肺动脉高压、心律失常,甚至意识丧失和心脏骤停。因此,在手术中正确预防和处理BCIS对患者的生命安全具有重要意义。本文旨在综合分析骨水泥植入综合征预防和处理的研究进展,正确识别发生BCIS的高危因素,概述各种预防措施及处理方法,以期为临床骨水泥植入综合征预防和处理提供参考。
Abstract: Bone cement implantation syndrome (BCIS) is a recognized and potentially fatal complication in orthopedic surgeries involving compressed bone cement, and this syndrome is mainly seen in bone cement-type joint replacement surgeries. Bone cement-based joint replacement surgery, as a commonly used and effective treatment method in orthopedics, is widely applied in clinical practice. However, it is worth noting that the use of bone cement during joint replacement surgery may cause bone cement implantation syndrome (BCIS). If this syndrome is not correctly identified and managed during the operation, it may lead to hypoxia, systemic hypotension, pulmonary hypertension, arrhythmia, and even loss of consciousness and cardiac arrest in patients. Therefore, the correct prevention and management of BCIS during surgery is of great significance to the life safety of patients. This article aims to comprehensively analyze the research progress in the prevention and treatment of bone cement implantation syndrome, correctly identify the high-risk factors for the occurrence of BCIS, and summarize various preventive measures and treatment methods, with the expectation of providing a reference for the prevention and treatment of bone cement implantation syndrome in clinical practice.
文章引用:贾迎奥, 王飞, 陈梦飞, 梁嘉文. 骨科手术中BCIS预防和处理的研究进展[J]. 临床医学进展, 2025, 15(7): 1241-1246. https://doi.org/10.12677/acm.2025.1572119

参考文献

[1] Lin, F.F., Chen, Y.F., Chen, B., Lin, C.H. and Zheng, K. (2019) Cemented versus Uncemented Hemiarthroplasty for Displaced Femoral Neck Fractures: A Meta-Analysis of Randomized Controlled Trails. Medicine, 98, e14634. [Google Scholar] [CrossRef] [PubMed]
[2] Olsen, F., Hård Af Segerstad, M., Nellgård, B., Houltz, E. and Ricksten, S. (2020) The Role of Bone Cement for the Development of Intraoperative Hypotension and Hypoxia and Its Impact on Mortality in Hemiarthroplasty for Femoral Neck Fractures. Acta Orthopaedica, 91, 293-298. [Google Scholar] [CrossRef] [PubMed]
[3] Weingärtner, K., Störmann, P., Schramm, D., Wutzler, S., Zacharowski, K., Marzi, I., et al. (2021) Bone Cement Implantation Syndrome in Cemented Hip Hemiarthroplasty—A Persistent Risk. European Journal of Trauma and Emergency Surgery, 48, 721-729. [Google Scholar] [CrossRef] [PubMed]
[4] Bonfait, H., Delaunay, C., De Thomasson, E., Tracol, P. and Werther, J. (2022) Bone Cement Implantation Syndrome in Hip Arthroplasty: Frequency, Severity and Prevention. Orthopaedics & Traumatology: Surgery & Research, 108, Article ID: 103139. [Google Scholar] [CrossRef] [PubMed]
[5] George, N.E. (2021) CORR Insights®: What Are the Frequency, Related Mortality, and Factors Associated with Bone Cement Implantation Syndrome in Arthroplasty Surgery? Clinical Orthopaedics & Related Research, 479, 764-766. [Google Scholar] [CrossRef] [PubMed]
[6] Rutter, P.D., Panesar, S.S., Darzi, A. and Donaldson, L.J. (2014) What Is the Risk of Death or Severe Harm Due to Bone Cement Implantation Syndrome among Patients Undergoing Hip Hemiarthroplasty for Fractured Neck of Femur? A Patient Safety Surveillance Study. BMJ Open, 4, e004853. [Google Scholar] [CrossRef] [PubMed]
[7] Wang, Z., Wishman, M.D., Tutaworn, T., Hentschel, I.G., Levin, J.E. and Lane, J.M. (2024) Osteoporosis and Cement Usage in Total Hip Arthroplasty. European Journal of Orthopaedic Surgery & Traumatology, 34, 1649-1655. [Google Scholar] [CrossRef] [PubMed]
[8] Nantha Kumar, N., Kunutsor, S.K., Fernandez, M.A., Dominguez, E., Parsons, N., Costa, M.L., et al. (2020) Effectiveness and Safety of Cemented and Uncemented Hemiarthroplasty in the Treatment of Intracapsular Hip Fractures. The Bone & Joint Journal, 102, 1113-1121. [Google Scholar] [CrossRef] [PubMed]
[9] Dahl, O.E., Pripp, A.H., Jaradeh, M. and Fareed, J. (2023) The Bone Cement Hypercoagulation Syndrome: Pathophysiology, Mortality, and Prevention. Clinical and Applied Thrombosis/Hemostasis, 29, 1-9. [Google Scholar] [CrossRef] [PubMed]
[10] Kotyra, M., Houltz, E. and Ricksten, S. (2010) Pulmonary Haemodynamics and Right Ventricular Function during Cemented Hemiarthroplasty for Femoral Neck Fracture. Acta Anaesthesiologica Scandinavica, 54, 1210-1216. [Google Scholar] [CrossRef] [PubMed]
[11] Segerstad, M.H.A., Olsen, F., Patel, A., Houltz, E., Nellgård, B. and Ricksten, S. (2018) Pulmonary Haemodynamics and Right Ventricular Function in Cemented vs Uncemented Total Hip Arthroplasty—A Randomized Trial. Acta Anaesthesiologica Scandinavica, 63, 298-305. [Google Scholar] [CrossRef] [PubMed]
[12] ten Hagen, A., Doldersum, P. and van Raaij, T. (2016) Anaphylactic Shock during Cement Implantation of a Total Hip Arthroplasty in a Patient with Underlying Mastocytosis: Case Report of a Rare Intraoperative Complication. Patient Safety in Surgery, 10, Article No. 25. [Google Scholar] [CrossRef] [PubMed]
[13] Tryba, M., Linde, I., Voshage, G., et al. (1991) [Histamine Release and Cardiovascular Reactions to Implantation of Bone Cement during Total Hip Replacement]. Anaesthesist, 40, 25-32.
[14] Dradjat, R.S., Pradana, A.S., Putra, D.P., Hexa Pandiangan, R.A., Cendikiawan, F. and Mustamsir, E. (2021) Successful Management of Severe Manifestation Bone Cemented Implantation Syndrome during Hemiarthroplasty Surgery in Patient with Multiple Comorbidities: A Case Report. International Journal of Surgery Case Reports, 78, 331-335. [Google Scholar] [CrossRef] [PubMed]
[15] 韩广弢, 王钦, 孙朔, 等. 骨水泥植入综合征病因及预防研究进展[J]. 中国修复重建外科杂志, 2025, 39(2): 237-242.
[16] 张富荣, 何亮, 李军民, 等. 乌司他丁联合肾上腺素对人工髋关节置换术中骨水泥植入综合征的预防作用[J]. 中国骨与关节损伤杂志, 2014, 29(4): 316-318.
[17] 徐岩, 窦建洪, 迮浩诚, 等. 老年患者关节置换术中发生严重骨水泥植入综合征高危因素回顾性分析[J]. 现代医院, 2020, 20(12): 1862-1865.
[18] 张蒙, 刘培来. 骨水泥植入综合征发病机制及诊治研究进展[J]. 山东医药, 2020, 60(6): 109-112.
[19] Dumanlı Özcan, A., Kesimci, E., Balcı, C., Kanbak, O., Kaşıkara, H. and But, A. (2018) Comparison between Colloid Preload and Coload in Bone Cement Implantation Syndrome under Spinal Anesthesia: A Randomized Controlled Trial. Anesthesia: Essays and Researches, 12, 879-884. [Google Scholar] [CrossRef] [PubMed]
[20] Tsai, M., Ng, Y., Chen, W., Tsai, S. and Wu, S. (2019) The Effects of Cement Fixation on Survival in Elderly Patients with Hip Hemiarthroplasty: A Nationwide Cohort Study. BMC Musculoskeletal Disorders, 20, Article No. 628. [Google Scholar] [CrossRef] [PubMed]