低氧相关基因在肾透明细胞癌中的研究进展
Research Progress of Hypoxia Related Genes in Renal Clear Cell Carcinoma
摘要: 肾透明细胞癌是肾癌中最常见的类型，低氧相关基因在其发生、发展、诊断、治疗及预后等方面发挥着关键作用。本文通过生物信息学分析、临床数据整合及文献综述，系统探讨了低氧相关基因在肾透明细胞癌中的基础理论(包括生物信息学方法、病理机制与表达调控)、流行病学特征、诊断技术、治疗策略、预后预测及研究争议与展望。研究发现，低氧诱导因子(HIF)通路、免疫微环境调控及代谢相关基因是当前研究热点，基于低氧相关基因的风险分层模型和分子标志物在临床应用中具有显著潜力。未来研究需关注基因异质性、多组学整合及新兴技术(如单细胞测序、CRISPR编辑)的应用。本文为肾透明细胞癌的基础研究与临床转化提供了全面参考。
Abstract: Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cancer, and hypoxia-related genes play a critical role in their occurrence, development, diagnosis, treatment, and prognosis. Through bioinformatics analysis, clinical data integration, and literature review, this paper systematically discusses the basic theories of hypoxia-related genes in ccRCC, including bioinformatics methods, pathological mechanisms, and expression regulation, as well as their epidemiological characteristics, diagnostic techniques, treatment strategies, prognostic prediction, and research controversies and prospects. The study finds that the hypoxia-inducible factor (HIF) pathway, immune microenvironment regulation, and metabolism-related genes are current research hotspots. Risk stratification models and molecular markers based on hypoxia-related genes show significant potential in clinical applications. Future research should focus on gene heterogeneity, multi-omics integration, and the application of emerging technologies such as single-cell sequencing and CRISPR editing. This paper provides a comprehensive reference for basic research and clinical translation in ccRCC.
文章引用：晏巧华, 阮天, 黄月, 李明航, 张梓悦, 李东梅, 杨清媛, 王慧. 低氧相关基因在肾透明细胞癌中的研究进展[J]. 临床个性化医学, 2025, 4(4): 77-83. https://doi.org/10.12677/jcpm.2025.44419

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