骨膜蛋白在慢性阻塞性肺疾病中的研究进展

Research Progress of Periostin in Chronic Obstructive Pulmonary Disease

摘要: 慢性阻塞性肺病(COPD)是一种以慢性气道炎症反应为病理基础的临床常见呼吸系统疾病，慢阻肺可防可控，其典型的临床特点是持久的呼吸道症状及进行性的气流受限。骨膜蛋白属于细胞外基质的重要组成部分，在组织形成、纤维化进程等方面都起到了非常关键的作用。最新的研究显示，它在COPD的炎症反应、气道重塑、肺血管重塑以及肺泡结构破坏等病理过程中起到重要作用，与COPD的病情进展、肺功能损害程度变化、急性加重、并发肺动脉高压等相关联，以骨膜蛋白为靶点的COPD治疗方法具有一定的临床前景。本综述汇总近年来的研究成果，对骨膜蛋白在COPD中的相关作用进行综述。

Abstract: Chronic obstructive pulmonary disease (COPD) is a common clinical respiratory disease based on chronic airway inflammatory responses. COPD is preventable and controllable, and its typical clinical characteristics are persistent respiratory symptoms and progressive airflow limitation. Periostin is an important component of the extracellular matrix and plays a very crucial role in tissue formation, the process of fibrosis, etc. The latest research shows that it plays an important role in pathological processes such as inflammatory response, airway remodeling, pulmonary vascular remodeling and alveolar structure destruction in COPD. It is associated with the progression of COPD, changes in the degree of lung function impairment, acute exacerbation, and concurrent pulmonary hypertension. The COPD treatment method targeting periostin has certain clinical prospects. This review summarizes the research results in recent years and reviews the related role of periostin in COPD.