2型糖尿病病理进程中多不饱和脂肪酸的多维度调控作用
Multi-Dimensional Regulatory Roles of Polyunsaturated Fatty Acids in the Pathological Progression of Type 2 Diabetes Mellitus
DOI: 10.12677/acm.2025.1582278, PDF,   
作者: 徐瑾睿, 刘 卉*：西安医学院第一附属医院血液科，陕西 西安；曹雨萌, 路思敏：西安医学院研究生院，陕西 西安
关键词: 2型糖尿病；多不饱和脂肪酸；胰岛素抵抗；炎症；氧化应激；传导通路；Type 2 Diabetes Mellitus； Polyunsaturated Fatty Acids； Insulin Resistance； Inflammation； Oxidative Stress； Transduction Pathways
摘要: 近年来，许多研究报道多不饱和脂肪酸与2型糖尿病的发生发展密切相关，其作用机制包括影响氧化应激、炎症反应、脂质代谢、信号传导通路、基因表达等方面，从而对糖尿病的发生发展起到调控作用。现通过对该领域相关研究进行归纳总结，探索ω-3与ω-6系列PUFAs对2型糖尿病的双向调控机制，重点解析其在炎症、氧化应激、脂代谢等关键路径中的作用差异，为精准营养干预提供理论依据，为临床管理糖尿病提供一定理论帮助。
Abstract: In recent years, numerous studies have demonstrated that polyunsaturated fatty acids (PUFAs) are closely associated with the occurrence and development of type 2 diabetes mellitus (T2DM). The underlying mechanisms involve influencing oxidative stress, inflammatory responses, lipid metabolism, signal transduction pathways, and gene expression, thereby regulating the occurrence and development of diabetes. By summarizing relevant research in this field, this study explores the bidirectional regulatory roles of ω-3 and ω-6 series PUFAs in T2DM, focusing on their differential effects in key pathways such as inflammation, oxidative stress, and lipid metabolism. The findings provide a theoretical basis for precision nutrition interventions and clinical management strategies for diabetes.
文章引用：徐瑾睿, 曹雨萌, 路思敏, 刘卉. 2型糖尿病病理进程中多不饱和脂肪酸的多维度调控作用[J]. 临床医学进展, 2025, 15(8): 648-656. https://doi.org/10.12677/acm.2025.1582278

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